Value of frontal QRS axis for risk stratification of individuals with prolonged PR interval
Abstract Background There is ongoing controversy regarding the prognostic value of PR prolongation among individuals free of cardiovascular diseases. It is necessary to risk‐stratify this population according to other electrocardiographic parameters. Methods This study is based on the Third National...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Annals of Noninvasive Electrocardiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/anec.13066 |
| _version_ | 1797782946238693376 |
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| author | Xiaodi Cao Zhe Wang Zhang Fang Chuanchuan Yu Linsheng Shi |
| author_facet | Xiaodi Cao Zhe Wang Zhang Fang Chuanchuan Yu Linsheng Shi |
| author_sort | Xiaodi Cao |
| collection | DOAJ |
| description | Abstract Background There is ongoing controversy regarding the prognostic value of PR prolongation among individuals free of cardiovascular diseases. It is necessary to risk‐stratify this population according to other electrocardiographic parameters. Methods This study is based on the Third National Health and Nutrition Examination Survey. Cox proportional hazard models were constructed and Kaplan–Meier method was used. Results A total of 6188 participants (58.1 ± 13.1 years; 55% women) were included. The median frontal QRS axis of the entire study population was 37° (IQR: 11–60°). PR prolongation was present in 7.6% of the participants, of whom 61.2% had QRS axis ≤37°. In a multivariable‐adjusted model, mortality risk was highest in the group with concomitant prolonged PR interval and QRS axis ≤37° (hazard ratio [HR]: 1.20; 95% confidence interval [CI]: 1.04–1.39). In models with similar adjustment where population were reclassified depending on PR prolongation and QRS axis, prolonged PR interval and QRS axis ≤37° was still associated with increased risk of mortality (HR: 1.18; 95% CI: 1.03–1.36) compared with normal PR interval. Conclusions QRS axis is an important factor for risk stratification in population with PR prolongation. The extent to which this population with PR prolongation and QRS axis ≤37° is at higher risk of death compared with the population without PR prolongation. |
| first_indexed | 2024-03-13T00:19:06Z |
| format | Article |
| id | doaj.art-2a30094d2687457da9b248c83cc9ea5e |
| institution | Directory Open Access Journal |
| issn | 1082-720X 1542-474X |
| language | English |
| last_indexed | 2024-03-13T00:19:06Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Noninvasive Electrocardiology |
| spelling | doaj.art-2a30094d2687457da9b248c83cc9ea5e2023-07-11T16:43:54ZengWileyAnnals of Noninvasive Electrocardiology1082-720X1542-474X2023-07-01284n/an/a10.1111/anec.13066Value of frontal QRS axis for risk stratification of individuals with prolonged PR intervalXiaodi Cao0Zhe Wang1Zhang Fang2Chuanchuan Yu3Linsheng Shi4Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Medical Statistics, School of Public Health Sun Yat‐sen University Guangzhou ChinaDepartment of Cardiology The Second Affiliated Hospital of Nantong University Nantong ChinaAbstract Background There is ongoing controversy regarding the prognostic value of PR prolongation among individuals free of cardiovascular diseases. It is necessary to risk‐stratify this population according to other electrocardiographic parameters. Methods This study is based on the Third National Health and Nutrition Examination Survey. Cox proportional hazard models were constructed and Kaplan–Meier method was used. Results A total of 6188 participants (58.1 ± 13.1 years; 55% women) were included. The median frontal QRS axis of the entire study population was 37° (IQR: 11–60°). PR prolongation was present in 7.6% of the participants, of whom 61.2% had QRS axis ≤37°. In a multivariable‐adjusted model, mortality risk was highest in the group with concomitant prolonged PR interval and QRS axis ≤37° (hazard ratio [HR]: 1.20; 95% confidence interval [CI]: 1.04–1.39). In models with similar adjustment where population were reclassified depending on PR prolongation and QRS axis, prolonged PR interval and QRS axis ≤37° was still associated with increased risk of mortality (HR: 1.18; 95% CI: 1.03–1.36) compared with normal PR interval. Conclusions QRS axis is an important factor for risk stratification in population with PR prolongation. The extent to which this population with PR prolongation and QRS axis ≤37° is at higher risk of death compared with the population without PR prolongation.https://doi.org/10.1111/anec.13066electrocardiogram indicatorsPR intervalQRS axisrisk stratification |
| spellingShingle | Xiaodi Cao Zhe Wang Zhang Fang Chuanchuan Yu Linsheng Shi Value of frontal QRS axis for risk stratification of individuals with prolonged PR interval Annals of Noninvasive Electrocardiology electrocardiogram indicators PR interval QRS axis risk stratification |
| title | Value of frontal QRS axis for risk stratification of individuals with prolonged PR interval |
| title_full | Value of frontal QRS axis for risk stratification of individuals with prolonged PR interval |
| title_fullStr | Value of frontal QRS axis for risk stratification of individuals with prolonged PR interval |
| title_full_unstemmed | Value of frontal QRS axis for risk stratification of individuals with prolonged PR interval |
| title_short | Value of frontal QRS axis for risk stratification of individuals with prolonged PR interval |
| title_sort | value of frontal qrs axis for risk stratification of individuals with prolonged pr interval |
| topic | electrocardiogram indicators PR interval QRS axis risk stratification |
| url | https://doi.org/10.1111/anec.13066 |
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