Altered Expression of Intestinal Tight Junction Proteins in Heart Failure Patients with Reduced or Preserved Ejection Fraction: A Pathogenetic Mechanism of Intestinal Hyperpermeability

Altered Expression of Intestinal Tight Junction Proteins in Heart Failure Patients with Reduced or Preserved Ejection Fraction: A Pathogenetic Mechanism of Intestinal Hyperpermeability

Although intestinal microbiota alterations (dysbiosis) have been described in heart failure (HF) patients, the possible mechanisms of intestinal barrier dysfunction leading to endotoxemia and systemic inflammation are not fully understood. In this study, we investigated the expression of the intesti...

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Bibliographic Details
Main Authors: Eleni-Evangelia Koufou, Stelios F. Assimakopoulos, Pinelopi Bosgana, Anne-Lise de Lastic, Ioanna-Maria Grypari, Georgia-Andriana Georgopoulou, Stefania Antonopoulou, Athanasia Mouzaki, Helen P. Kourea, Konstantinos Thomopoulos, Periklis Davlouros
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Biomedicines
Subjects:
heart failure
intestinal hyperpermeability
systemic endotoxemia
systemic inflammation
tight junction dysfunction
Online Access:https://www.mdpi.com/2227-9059/12/1/160

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