Thyroid dysfunction in COVID-19
Objective: The aim of this study was to evaluate thyroid dysfunction in COVID-19 and study its association with disease severity in COVID-19. Methods: Patients with confirmed COVID-19 infection who were admitted to dedicated COVID hospital were recruited over 3 months period. Those with pre-existing...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2021;volume=25;issue=3;spage=198;epage=201;aulast=Dabas |
| _version_ | 1818398302207475712 |
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| author | Aashima Dabas Harpreet Singh Binita Goswami Kunal Kumar Abhishek Dubey Urmila Jhamb Sangeeta Yadav Sandeep Garg |
| author_facet | Aashima Dabas Harpreet Singh Binita Goswami Kunal Kumar Abhishek Dubey Urmila Jhamb Sangeeta Yadav Sandeep Garg |
| author_sort | Aashima Dabas |
| collection | DOAJ |
| description | Objective: The aim of this study was to evaluate thyroid dysfunction in COVID-19 and study its association with disease severity in COVID-19. Methods: Patients with confirmed COVID-19 infection who were admitted to dedicated COVID hospital were recruited over 3 months period. Those with pre-existing thyroid disease were excluded. The thyroid function tests were performed and correlated with interleukin-6 levels. Results: A total of 164 patients (14 children) with mean(SD) age 53.85 (19.54) years were recruited. The proportion of patients with mild, moderate and severe disease were 22 (13.4%), 78 (47.6%) and 64 (39.0%), respectively, among which 12 (54.5%), 56 (71.8%) and 43 (67.2%) patients had thyroid dysfunction, respectively; P = 0.309. Eighty eight (53.7%) had sick euthyroid (84 had low fT3 only), 14 had overt hypothyroidism and 9 had thyroiditis. Median (IQR) levels of serum fT3 showed significant decline from mild category [4.54 (3.81, 5.27)], to moderate [3.95 (3.67, 4.24)] and severe category [3.56 (3.22, 3.89)]; P = 0.011. Low fT3 had significant risk [odds ratio (95% CI)] of death [2.634 (1.01, 6.87); P = 0.031] and elevated IL-6 [2.575 (1.084, 6.118); P = 0.021]. Conclusion: Sick euthyroid was seen in the majority of patients hospitalized with COVID. Low fT3 was associated with death and increased inflammation, suggesting poor prognosis. |
| first_indexed | 2024-12-14T07:02:37Z |
| format | Article |
| id | doaj.art-2a329787220c41778287b0651067a93f |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-12-14T07:02:37Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-2a329787220c41778287b0651067a93f2022-12-21T23:12:22ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102021-01-0125319820110.4103/ijem.ijem_195_21Thyroid dysfunction in COVID-19Aashima DabasHarpreet SinghBinita GoswamiKunal KumarAbhishek DubeyUrmila JhambSangeeta YadavSandeep GargObjective: The aim of this study was to evaluate thyroid dysfunction in COVID-19 and study its association with disease severity in COVID-19. Methods: Patients with confirmed COVID-19 infection who were admitted to dedicated COVID hospital were recruited over 3 months period. Those with pre-existing thyroid disease were excluded. The thyroid function tests were performed and correlated with interleukin-6 levels. Results: A total of 164 patients (14 children) with mean(SD) age 53.85 (19.54) years were recruited. The proportion of patients with mild, moderate and severe disease were 22 (13.4%), 78 (47.6%) and 64 (39.0%), respectively, among which 12 (54.5%), 56 (71.8%) and 43 (67.2%) patients had thyroid dysfunction, respectively; P = 0.309. Eighty eight (53.7%) had sick euthyroid (84 had low fT3 only), 14 had overt hypothyroidism and 9 had thyroiditis. Median (IQR) levels of serum fT3 showed significant decline from mild category [4.54 (3.81, 5.27)], to moderate [3.95 (3.67, 4.24)] and severe category [3.56 (3.22, 3.89)]; P = 0.011. Low fT3 had significant risk [odds ratio (95% CI)] of death [2.634 (1.01, 6.87); P = 0.031] and elevated IL-6 [2.575 (1.084, 6.118); P = 0.021]. Conclusion: Sick euthyroid was seen in the majority of patients hospitalized with COVID. Low fT3 was associated with death and increased inflammation, suggesting poor prognosis.http://www.ijem.in/article.asp?issn=2230-8210;year=2021;volume=25;issue=3;spage=198;epage=201;aulast=Dabashypothyroidismil-6inflammatory markersick euthyroidthyroiditis |
| spellingShingle | Aashima Dabas Harpreet Singh Binita Goswami Kunal Kumar Abhishek Dubey Urmila Jhamb Sangeeta Yadav Sandeep Garg Thyroid dysfunction in COVID-19 Indian Journal of Endocrinology and Metabolism hypothyroidism il-6 inflammatory marker sick euthyroid thyroiditis |
| title | Thyroid dysfunction in COVID-19 |
| title_full | Thyroid dysfunction in COVID-19 |
| title_fullStr | Thyroid dysfunction in COVID-19 |
| title_full_unstemmed | Thyroid dysfunction in COVID-19 |
| title_short | Thyroid dysfunction in COVID-19 |
| title_sort | thyroid dysfunction in covid 19 |
| topic | hypothyroidism il-6 inflammatory marker sick euthyroid thyroiditis |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2021;volume=25;issue=3;spage=198;epage=201;aulast=Dabas |
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