PULMONARY MYCOSES AMONG CLINICALLY SUSPECTED CASES OF PULMONARY TUBERCULOSIS IN KEBBI STATE NORTHERN NIGERIA
Intro: Pulmonary mycoses are a fungal infection that resembles pulmonary tuberculosis (PTB). The diagnosis of pulmonary mycosis is difficult because the disease does not present a specific clinic manifestation. This study aimed to investigate pulmonary mycoses among patients with clinical features a...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223003582 |
| _version_ | 1797824559210037248 |
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| author | M. Danlami B. Aliyu A. Adepowope |
| author_facet | M. Danlami B. Aliyu A. Adepowope |
| author_sort | M. Danlami |
| collection | DOAJ |
| description | Intro: Pulmonary mycoses are a fungal infection that resembles pulmonary tuberculosis (PTB). The diagnosis of pulmonary mycosis is difficult because the disease does not present a specific clinic manifestation. This study aimed to investigate pulmonary mycoses among patients with clinical features and suspected cases of pulmonary tuberculosis in the PTB endemic area of Nigeria. Methods: Three hundred sputum samples were collected from pulmonary tuberculosis patients. For each sample, the following tests were performed: Sabouraud dextrose agar for fungal culture, acid-fast bacilli (AFB) and GeneXpert for Mycobacteria tuberculosis (MTB) and potassium hydroxide for fungal screening. Filamentous fungal growth and yeasts were further examined with lactophenol cotton blue staining and germ tube respectively. Findings: Of the 300-suspected cases, 50 were positive for AFB and 147 (43.7%) had fungal pathogens isolated from their sputum samples. 33 (22.4%) of the 147 fungal pathogens were co-infection with suspected cases of PTB, of which 7 (4.8%) are rifampicin resistance MTB. Among the isolated pulmonary fungal pathogens, Candida albicans 44 (14.7%) and Blastomyces Percursus 43 (14.3%) had the highest occurrence, Aspergillus fumigatus 32 (10.7%), Aspergillus niger 14 (4.7%), and Candida tropicalis 9 (2.3%). Conclusion: The study has shown that cases of pulmonary mycosis are likely to be misdiagnosed as pulmonary tuberculosis. In addition, Mycobacterium tuberculosis-infected patients are susceptible to many fungal pathogens. Therefore, there is a need for routine diagnosis of pulmonary mycoses among cases of pulmonary tuberculosis for a successful tuberculosis treatment program. |
| first_indexed | 2024-03-13T10:40:47Z |
| format | Article |
| id | doaj.art-2a3337adb72246cc8d131d9a2c3a2cab |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-03-13T10:40:47Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-2a3337adb72246cc8d131d9a2c3a2cab2023-05-18T04:38:43ZengElsevierInternational Journal of Infectious Diseases1201-97122023-05-01130S92PULMONARY MYCOSES AMONG CLINICALLY SUSPECTED CASES OF PULMONARY TUBERCULOSIS IN KEBBI STATE NORTHERN NIGERIAM. Danlami0B. Aliyu1A. Adepowope2Federal University Birnin Kebbi, Microbiology, Birnin Kebbi, NigeriaFederal University Birnin Kebbi, Microbiology, Birnin Kebbi, NigeriaKebbi State University of Science and Technology Aliero, Microbiology, Aliero, NigeriaIntro: Pulmonary mycoses are a fungal infection that resembles pulmonary tuberculosis (PTB). The diagnosis of pulmonary mycosis is difficult because the disease does not present a specific clinic manifestation. This study aimed to investigate pulmonary mycoses among patients with clinical features and suspected cases of pulmonary tuberculosis in the PTB endemic area of Nigeria. Methods: Three hundred sputum samples were collected from pulmonary tuberculosis patients. For each sample, the following tests were performed: Sabouraud dextrose agar for fungal culture, acid-fast bacilli (AFB) and GeneXpert for Mycobacteria tuberculosis (MTB) and potassium hydroxide for fungal screening. Filamentous fungal growth and yeasts were further examined with lactophenol cotton blue staining and germ tube respectively. Findings: Of the 300-suspected cases, 50 were positive for AFB and 147 (43.7%) had fungal pathogens isolated from their sputum samples. 33 (22.4%) of the 147 fungal pathogens were co-infection with suspected cases of PTB, of which 7 (4.8%) are rifampicin resistance MTB. Among the isolated pulmonary fungal pathogens, Candida albicans 44 (14.7%) and Blastomyces Percursus 43 (14.3%) had the highest occurrence, Aspergillus fumigatus 32 (10.7%), Aspergillus niger 14 (4.7%), and Candida tropicalis 9 (2.3%). Conclusion: The study has shown that cases of pulmonary mycosis are likely to be misdiagnosed as pulmonary tuberculosis. In addition, Mycobacterium tuberculosis-infected patients are susceptible to many fungal pathogens. Therefore, there is a need for routine diagnosis of pulmonary mycoses among cases of pulmonary tuberculosis for a successful tuberculosis treatment program.http://www.sciencedirect.com/science/article/pii/S1201971223003582 |
| spellingShingle | M. Danlami B. Aliyu A. Adepowope PULMONARY MYCOSES AMONG CLINICALLY SUSPECTED CASES OF PULMONARY TUBERCULOSIS IN KEBBI STATE NORTHERN NIGERIA International Journal of Infectious Diseases |
| title | PULMONARY MYCOSES AMONG CLINICALLY SUSPECTED CASES OF PULMONARY TUBERCULOSIS IN KEBBI STATE NORTHERN NIGERIA |
| title_full | PULMONARY MYCOSES AMONG CLINICALLY SUSPECTED CASES OF PULMONARY TUBERCULOSIS IN KEBBI STATE NORTHERN NIGERIA |
| title_fullStr | PULMONARY MYCOSES AMONG CLINICALLY SUSPECTED CASES OF PULMONARY TUBERCULOSIS IN KEBBI STATE NORTHERN NIGERIA |
| title_full_unstemmed | PULMONARY MYCOSES AMONG CLINICALLY SUSPECTED CASES OF PULMONARY TUBERCULOSIS IN KEBBI STATE NORTHERN NIGERIA |
| title_short | PULMONARY MYCOSES AMONG CLINICALLY SUSPECTED CASES OF PULMONARY TUBERCULOSIS IN KEBBI STATE NORTHERN NIGERIA |
| title_sort | pulmonary mycoses among clinically suspected cases of pulmonary tuberculosis in kebbi state northern nigeria |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223003582 |
| work_keys_str_mv | AT mdanlami pulmonarymycosesamongclinicallysuspectedcasesofpulmonarytuberculosisinkebbistatenorthernnigeria AT baliyu pulmonarymycosesamongclinicallysuspectedcasesofpulmonarytuberculosisinkebbistatenorthernnigeria AT aadepowope pulmonarymycosesamongclinicallysuspectedcasesofpulmonarytuberculosisinkebbistatenorthernnigeria |