Interferon Beta-1b Level in Parkinson’s Disease: Before and After SARS-CoV-2 Vaccination
Background: Parkinson’s disease (PD) is a neurodegenerative disease. Immune response varies after vaccination in different patients. We aimed to evaluate interferon beta-1b (IFNβ-1b) level in patients with PD in response to inactivated SARS-CoV-2 (CoronaVac) vaccination. Methods: Eight patients with...
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| Format: | Article |
| Language: | English |
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Shahid Beheshti University of Medical Sciences
2022-01-01
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| Series: | International Clinical Neuroscience Journal |
| Subjects: | |
| Online Access: | http://journals.sbmu.ac.ir/neuroscience/PDF/icnj-9-e23.pdf |
| _version_ | 1797829388981501952 |
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| author | Yaprak Dönmez Çakıl Zeynep Güneş Özünal Sibel Karsıdağ Şevki Şahin |
| author_facet | Yaprak Dönmez Çakıl Zeynep Güneş Özünal Sibel Karsıdağ Şevki Şahin |
| author_sort | Yaprak Dönmez Çakıl |
| collection | DOAJ |
| description | Background: Parkinson’s disease (PD) is a neurodegenerative disease. Immune response varies after vaccination in different patients. We aimed to evaluate interferon beta-1b (IFNβ-1b) level in patients with PD in response to inactivated SARS-CoV-2 (CoronaVac) vaccination. Methods: Eight patients with the diagnosis of idiopathic PD and followed in the outpatient clinic (stages 1-2) were enrolled. Total blood count was performed before vaccination. IFNβ-1b levels were measured by ELISA and motor examination was performed before and two hours after vaccination. Results: IFNβ-1b levels increased in three patients, whereas no change was detected in one patient and the levels decreased in four patients. Divergent responses were found related to the time of diagnosis. Conclusion: The time of PD diagnosis, as well as the age of the patients, may be responsible for the variability of the post-vaccine immune response. |
| first_indexed | 2024-04-09T13:20:44Z |
| format | Article |
| id | doaj.art-2a335a6f26444963afb2bbafc919154b |
| institution | Directory Open Access Journal |
| issn | 2383-1871 2383-2096 |
| language | English |
| last_indexed | 2024-04-09T13:20:44Z |
| publishDate | 2022-01-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | International Clinical Neuroscience Journal |
| spelling | doaj.art-2a335a6f26444963afb2bbafc919154b2023-05-11T06:51:46ZengShahid Beheshti University of Medical SciencesInternational Clinical Neuroscience Journal2383-18712383-20962022-01-0191e23e2310.34172/icnj.2022.23icnj-17187Interferon Beta-1b Level in Parkinson’s Disease: Before and After SARS-CoV-2 VaccinationYaprak Dönmez Çakıl0Zeynep Güneş Özünal1Sibel Karsıdağ2Şevki Şahin3Maltepe University, Faculty of Medicine, Department of Histology and Embryology, Istanbul, TurkeyMaltepe University, Cancer and Stem Cell Research Center, Istanbul, TurkeyDepartment of Neurology, Hamidiye School of Medicine, University of Health Science, Sultan Abdulhamid Han Research and Training Hospital, Istanbul, TurkeyDepartment of Neurology, Sancaktepe Şehit Prof. Ilhan Varank Research and Training Hospital, Istanbul, TurkeyBackground: Parkinson’s disease (PD) is a neurodegenerative disease. Immune response varies after vaccination in different patients. We aimed to evaluate interferon beta-1b (IFNβ-1b) level in patients with PD in response to inactivated SARS-CoV-2 (CoronaVac) vaccination. Methods: Eight patients with the diagnosis of idiopathic PD and followed in the outpatient clinic (stages 1-2) were enrolled. Total blood count was performed before vaccination. IFNβ-1b levels were measured by ELISA and motor examination was performed before and two hours after vaccination. Results: IFNβ-1b levels increased in three patients, whereas no change was detected in one patient and the levels decreased in four patients. Divergent responses were found related to the time of diagnosis. Conclusion: The time of PD diagnosis, as well as the age of the patients, may be responsible for the variability of the post-vaccine immune response.http://journals.sbmu.ac.ir/neuroscience/PDF/icnj-9-e23.pdfparkinson’s diseaseinterferon beta-1bcovid-19vaccinationimmune responseinflammationcytokine |
| spellingShingle | Yaprak Dönmez Çakıl Zeynep Güneş Özünal Sibel Karsıdağ Şevki Şahin Interferon Beta-1b Level in Parkinson’s Disease: Before and After SARS-CoV-2 Vaccination International Clinical Neuroscience Journal parkinson’s disease interferon beta-1b covid-19 vaccination immune response inflammation cytokine |
| title | Interferon Beta-1b Level in Parkinson’s Disease: Before and After SARS-CoV-2 Vaccination |
| title_full | Interferon Beta-1b Level in Parkinson’s Disease: Before and After SARS-CoV-2 Vaccination |
| title_fullStr | Interferon Beta-1b Level in Parkinson’s Disease: Before and After SARS-CoV-2 Vaccination |
| title_full_unstemmed | Interferon Beta-1b Level in Parkinson’s Disease: Before and After SARS-CoV-2 Vaccination |
| title_short | Interferon Beta-1b Level in Parkinson’s Disease: Before and After SARS-CoV-2 Vaccination |
| title_sort | interferon beta 1b level in parkinson s disease before and after sars cov 2 vaccination |
| topic | parkinson’s disease interferon beta-1b covid-19 vaccination immune response inflammation cytokine |
| url | http://journals.sbmu.ac.ir/neuroscience/PDF/icnj-9-e23.pdf |
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