A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
Matrine (MT) is a naturally occurring alkaloid and an bioactive component of Chinese herbs, such as Sophora flavescens and Radix Sophorae tonkinensis. Emerging evidence suggests that MT possesses anti-cancer, anti-inflammatory, anti-oxidant, antiviral, antimicrobial, anti-fibrotic, anti-allergic, an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.01067/full |
| _version_ | 1819092106694623232 |
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| author | Longtai You Chunjing Yang Yuanyuan Du Wenping Wang Mingyi Sun Jing Liu Baorui Ma Linnuo Pang Yawen Zeng Zhiqin Zhang Xiaoxv Dong Xingbin Yin Jian Ni |
| author_facet | Longtai You Chunjing Yang Yuanyuan Du Wenping Wang Mingyi Sun Jing Liu Baorui Ma Linnuo Pang Yawen Zeng Zhiqin Zhang Xiaoxv Dong Xingbin Yin Jian Ni |
| author_sort | Longtai You |
| collection | DOAJ |
| description | Matrine (MT) is a naturally occurring alkaloid and an bioactive component of Chinese herbs, such as Sophora flavescens and Radix Sophorae tonkinensis. Emerging evidence suggests that MT possesses anti-cancer, anti-inflammatory, anti-oxidant, antiviral, antimicrobial, anti-fibrotic, anti-allergic, antinociceptive, hepatoprotective, cardioprotective, and neuroprotective properties. These pharmacological properties form the foundation for its application in the treatment of various diseases, such as multiple types of cancers, hepatitis, skin diseases, allergic asthma, diabetic cardiomyopathy, pain, Alzheimer’s disease (AD), Parkinson’s disease (PD), and central nervous system (CNS) inflammation. However, an increasing number of published studies indicate that MT has serious adverse effects, the most obvious being liver toxicity and neurotoxicity, which are major factors limiting its clinical use. Pharmacokinetic studies have shown that MT has low oral bioavailability and short half-life in vivo. This review summarizes the latest advances in research on the pharmacology, toxicology, and pharmacokinetics of MT, with a focus on its biological properties and mechanism of action. The review provides insight into the future of research on traditional Chinese medicine. |
| first_indexed | 2024-12-21T22:50:21Z |
| format | Article |
| id | doaj.art-2a35186e4d46435d98012afed1dccf01 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-21T22:50:21Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2a35186e4d46435d98012afed1dccf012022-12-21T18:47:36ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-09-011110.3389/fphar.2020.01067518242A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of MatrineLongtai You0Chunjing Yang1Yuanyuan Du2Wenping Wang3Mingyi Sun4Jing Liu5Baorui Ma6Linnuo Pang7Yawen Zeng8Zhiqin Zhang9Xiaoxv Dong10Xingbin Yin11Jian Ni12School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Pharmacy, Beijing Shijitan Hospital Affiliated to Capital University of Medical Sciences, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaBeijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaMatrine (MT) is a naturally occurring alkaloid and an bioactive component of Chinese herbs, such as Sophora flavescens and Radix Sophorae tonkinensis. Emerging evidence suggests that MT possesses anti-cancer, anti-inflammatory, anti-oxidant, antiviral, antimicrobial, anti-fibrotic, anti-allergic, antinociceptive, hepatoprotective, cardioprotective, and neuroprotective properties. These pharmacological properties form the foundation for its application in the treatment of various diseases, such as multiple types of cancers, hepatitis, skin diseases, allergic asthma, diabetic cardiomyopathy, pain, Alzheimer’s disease (AD), Parkinson’s disease (PD), and central nervous system (CNS) inflammation. However, an increasing number of published studies indicate that MT has serious adverse effects, the most obvious being liver toxicity and neurotoxicity, which are major factors limiting its clinical use. Pharmacokinetic studies have shown that MT has low oral bioavailability and short half-life in vivo. This review summarizes the latest advances in research on the pharmacology, toxicology, and pharmacokinetics of MT, with a focus on its biological properties and mechanism of action. The review provides insight into the future of research on traditional Chinese medicine.https://www.frontiersin.org/article/10.3389/fphar.2020.01067/fullmatrinepharmacologytoxicologypharmacokineticsmechanisms |
| spellingShingle | Longtai You Chunjing Yang Yuanyuan Du Wenping Wang Mingyi Sun Jing Liu Baorui Ma Linnuo Pang Yawen Zeng Zhiqin Zhang Xiaoxv Dong Xingbin Yin Jian Ni A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine Frontiers in Pharmacology matrine pharmacology toxicology pharmacokinetics mechanisms |
| title | A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine |
| title_full | A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine |
| title_fullStr | A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine |
| title_full_unstemmed | A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine |
| title_short | A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine |
| title_sort | systematic review of the pharmacology toxicology and pharmacokinetics of matrine |
| topic | matrine pharmacology toxicology pharmacokinetics mechanisms |
| url | https://www.frontiersin.org/article/10.3389/fphar.2020.01067/full |
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