Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome
Abstract The aim of the present work was to study whether the leptin-adiponectin axis may have a pathophysiological role in the increased systemic inflammation and oxidative stress observed in patients with the metabolic syndrome (MS). Leptin, adiponectin, and markers of inflammation and oxidative s...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-06997-0 |
| _version_ | 1818842386623627264 |
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| author | Gema Frühbeck Victoria Catalán Amaia Rodríguez Beatriz Ramírez Sara Becerril Javier Salvador Piero Portincasa Inmaculada Colina Javier Gómez-Ambrosi |
| author_facet | Gema Frühbeck Victoria Catalán Amaia Rodríguez Beatriz Ramírez Sara Becerril Javier Salvador Piero Portincasa Inmaculada Colina Javier Gómez-Ambrosi |
| author_sort | Gema Frühbeck |
| collection | DOAJ |
| description | Abstract The aim of the present work was to study whether the leptin-adiponectin axis may have a pathophysiological role in the increased systemic inflammation and oxidative stress observed in patients with the metabolic syndrome (MS). Leptin, adiponectin, and markers of inflammation and oxidative stress were measured in a sample of 140 Caucasian subjects (74 males/66 females), aged 28–82 years, 60 with and 80 without the MS. Total concentrations of adiponectin as well as its multimeric forms HMW, MMW and LMW were significantly lower in individuals with the MS. The ratio adiponectin/leptin, a marker of dysfunctional adipose tissue, was dramatically decreased in the MS group. Systemic oxidative stress, as evidenced by levels of thiobarbituric acid reactive substances (TBARS), as well as markers of inflammation such as serum amyloid A (SAA), C-reactive protein (CRP) and osteopontin were significantly increased in subjects with the MS. Total adiponectin concentrations were negatively correlated with levels of TBARS and CRP levels. Furthermore, the ratio adiponectin/leptin was negatively correlated with SAA concentrations as well as with CRP levels. We concluded that a dysfunctional adipose tissue as suggested by a low adiponectin/leptin ratio may contribute to the increased oxidative stress and inflammation, hallmarks of the MS. |
| first_indexed | 2024-12-19T04:41:09Z |
| format | Article |
| id | doaj.art-2a36a18cf6754b04b71182003610214d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T04:41:09Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2a36a18cf6754b04b71182003610214d2022-12-21T20:35:36ZengNature PortfolioScientific Reports2045-23222017-07-01711810.1038/s41598-017-06997-0Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndromeGema Frühbeck0Victoria Catalán1Amaia Rodríguez2Beatriz Ramírez3Sara Becerril4Javier Salvador5Piero Portincasa6Inmaculada Colina7Javier Gómez-Ambrosi8Metabolic Research Laboratory, Clínica Universidad de NavarraMetabolic Research Laboratory, Clínica Universidad de NavarraMetabolic Research Laboratory, Clínica Universidad de NavarraMetabolic Research Laboratory, Clínica Universidad de NavarraMetabolic Research Laboratory, Clínica Universidad de NavarraCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos IIIClinica Medica “A. Murri”, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Policlinico HospitalObesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA)Metabolic Research Laboratory, Clínica Universidad de NavarraAbstract The aim of the present work was to study whether the leptin-adiponectin axis may have a pathophysiological role in the increased systemic inflammation and oxidative stress observed in patients with the metabolic syndrome (MS). Leptin, adiponectin, and markers of inflammation and oxidative stress were measured in a sample of 140 Caucasian subjects (74 males/66 females), aged 28–82 years, 60 with and 80 without the MS. Total concentrations of adiponectin as well as its multimeric forms HMW, MMW and LMW were significantly lower in individuals with the MS. The ratio adiponectin/leptin, a marker of dysfunctional adipose tissue, was dramatically decreased in the MS group. Systemic oxidative stress, as evidenced by levels of thiobarbituric acid reactive substances (TBARS), as well as markers of inflammation such as serum amyloid A (SAA), C-reactive protein (CRP) and osteopontin were significantly increased in subjects with the MS. Total adiponectin concentrations were negatively correlated with levels of TBARS and CRP levels. Furthermore, the ratio adiponectin/leptin was negatively correlated with SAA concentrations as well as with CRP levels. We concluded that a dysfunctional adipose tissue as suggested by a low adiponectin/leptin ratio may contribute to the increased oxidative stress and inflammation, hallmarks of the MS.https://doi.org/10.1038/s41598-017-06997-0 |
| spellingShingle | Gema Frühbeck Victoria Catalán Amaia Rodríguez Beatriz Ramírez Sara Becerril Javier Salvador Piero Portincasa Inmaculada Colina Javier Gómez-Ambrosi Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome Scientific Reports |
| title | Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome |
| title_full | Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome |
| title_fullStr | Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome |
| title_full_unstemmed | Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome |
| title_short | Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome |
| title_sort | involvement of the leptin adiponectin axis in inflammation and oxidative stress in the metabolic syndrome |
| url | https://doi.org/10.1038/s41598-017-06997-0 |
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