Global prevalence of antidepressant drug utilization in the community: protocol for a systematic review
Introduction Antidepressant drugs are the most frequently prescribed medication for mental disorders. They are also used off-label and for non-psychiatric indications. Prescriptions of antidepressants have increased in the last decades, but no systematic review exists on the extent of their use in t...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-05-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/5/e062197.full |
| _version_ | 1811274999422517248 |
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| author | Annie Leblanc Stéphane Turcotte Elisabetta Poluzzi Becky Skidmore Michèle Dugas Patrick Blouin Marie-Pier Déry Carlotta Lunghi Jacinthe Leclerc Cathy Martineau Valérie Carnovale Théo Stéfan Johanie Lépine Laura Jalbert Nataly R Espinoza Suarez Olha Svyntozelska Giraud Ekanmian Daniele Maria Nogueira Pelumi Samuel Akinola |
| author_facet | Annie Leblanc Stéphane Turcotte Elisabetta Poluzzi Becky Skidmore Michèle Dugas Patrick Blouin Marie-Pier Déry Carlotta Lunghi Jacinthe Leclerc Cathy Martineau Valérie Carnovale Théo Stéfan Johanie Lépine Laura Jalbert Nataly R Espinoza Suarez Olha Svyntozelska Giraud Ekanmian Daniele Maria Nogueira Pelumi Samuel Akinola |
| author_sort | Annie Leblanc |
| collection | DOAJ |
| description | Introduction Antidepressant drugs are the most frequently prescribed medication for mental disorders. They are also used off-label and for non-psychiatric indications. Prescriptions of antidepressants have increased in the last decades, but no systematic review exists on the extent of their use in the community.Methods and analysis We will conduct a systematic review to estimate the prevalence of antidepressant use in the community. We will search for studies published from 1 January 2010 in the Embase and MEDLINE databases using a combination of controlled vocabulary and keywords adjusted for each database without any language restriction. The main inclusion criterion is the presence of prevalence data of antidepressant utilization. Thus, we will include all studies with a descriptive observational design reporting the prevalence of antidepressant use in the community. Study selection (by title/abstract and full-text screening) and data extraction for included studies will be independently conducted by pairs of reviewers. We will then synthesize the data on the prevalence of antidepressant use in individuals living in the community. If possible, we will perform a meta-analysis to generate prevalence-pooled estimates. If the data allows it, we will conduct subgroup analyses by antidepressant class, age, sex, country and other sociodemographic categories. We will evaluate the risk of bias for each included study through a quality assessment using the Joanna Briggs Institute Critical Appraisal tool: Checklist for Studies Reporting Prevalence Data. DistillerSR software will be used for the management of this review.Ethics and dissemination Ethical approval is not required for this review as it will not directly involve human or animal subjects. The findings of our systematic review will be disseminated through publications in peer-reviewed journals, the Qualaxia Network (https://qualaxia.org), presentations at international conferences on mental health and pharmacoepidemiology, as well as general public events.PROSPERO registration number CRD42021247423. |
| first_indexed | 2024-04-12T23:30:09Z |
| format | Article |
| id | doaj.art-2a384b6026eb4c25a757b2064f6b000f |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-12T23:30:09Z |
| publishDate | 2022-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-2a384b6026eb4c25a757b2064f6b000f2022-12-22T03:12:18ZengBMJ Publishing GroupBMJ Open2044-60552022-05-0112510.1136/bmjopen-2022-062197Global prevalence of antidepressant drug utilization in the community: protocol for a systematic reviewAnnie Leblanc0Stéphane Turcotte1Elisabetta Poluzzi2Becky Skidmore3Michèle Dugas4Patrick Blouin5Marie-Pier Déry6Carlotta Lunghi7Jacinthe Leclerc8Cathy Martineau9Valérie Carnovale10Théo Stéfan11Johanie Lépine12Laura Jalbert13Nataly R Espinoza Suarez14Olha Svyntozelska15Giraud Ekanmian16Daniele Maria Nogueira17Pelumi Samuel Akinola18VITAM Research Center on Sustainable Health, Quebec Integrated University Health and Social Services Center, Quebec City, Quebec, CanadaCISSS de Chaudière-Appalaches Research Center, Lévis, Quebec, CanadaDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, ItalyIndependent Specialist, Ottawa, Ottawa, CanadaVITAM Research Center on Sustainable Health, Quebec Integrated University Health and Social Services Center, Quebec City, Quebec, CanadaVITAM Research Center on Sustainable Health, Quebec Integrated University Health and Social Services Center, Quebec City, Quebec, CanadaVITAM Research Center on Sustainable Health, Quebec Integrated University Health and Social Services Center, Quebec City, Quebec, CanadaDepartment of Health Sciences, Université du Québec à Rimouski, Lévis, Quebec, CanadaDepartment of Nursing, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec, CanadaDepartment of Health Sciences, Université du Québec à Rimouski, Lévis, Quebec, CanadaVITAM Research Center on Sustainable Health, Quebec Integrated University Health and Social Services Center, Quebec City, Quebec, CanadaVITAM Research Center on Sustainable Health, Quebec Integrated University Health and Social Services Center, Quebec City, Quebec, CanadaVITAM Research Center on Sustainable Health, Quebec Integrated University Health and Social Services Center, Quebec City, Quebec, CanadaVITAM Research Center on Sustainable Health, Quebec Integrated University Health and Social Services Center, Quebec City, Quebec, CanadaVITAM Research Center on Sustainable Health, Quebec Integrated University Health and Social Services Center, Quebec City, Quebec, CanadaVITAM Research Center on Sustainable Health, Quebec Integrated University Health and Social Services Center, Quebec City, Quebec, CanadaPopulation Heath and Optimal Health Practices Axis, CHU de Québec-Université Laval Research Center, Quebec, Quebec City, CanadaNursing College of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, BrazilDepartment of Nursing, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec, CanadaIntroduction Antidepressant drugs are the most frequently prescribed medication for mental disorders. They are also used off-label and for non-psychiatric indications. Prescriptions of antidepressants have increased in the last decades, but no systematic review exists on the extent of their use in the community.Methods and analysis We will conduct a systematic review to estimate the prevalence of antidepressant use in the community. We will search for studies published from 1 January 2010 in the Embase and MEDLINE databases using a combination of controlled vocabulary and keywords adjusted for each database without any language restriction. The main inclusion criterion is the presence of prevalence data of antidepressant utilization. Thus, we will include all studies with a descriptive observational design reporting the prevalence of antidepressant use in the community. Study selection (by title/abstract and full-text screening) and data extraction for included studies will be independently conducted by pairs of reviewers. We will then synthesize the data on the prevalence of antidepressant use in individuals living in the community. If possible, we will perform a meta-analysis to generate prevalence-pooled estimates. If the data allows it, we will conduct subgroup analyses by antidepressant class, age, sex, country and other sociodemographic categories. We will evaluate the risk of bias for each included study through a quality assessment using the Joanna Briggs Institute Critical Appraisal tool: Checklist for Studies Reporting Prevalence Data. DistillerSR software will be used for the management of this review.Ethics and dissemination Ethical approval is not required for this review as it will not directly involve human or animal subjects. The findings of our systematic review will be disseminated through publications in peer-reviewed journals, the Qualaxia Network (https://qualaxia.org), presentations at international conferences on mental health and pharmacoepidemiology, as well as general public events.PROSPERO registration number CRD42021247423.https://bmjopen.bmj.com/content/12/5/e062197.full |
| spellingShingle | Annie Leblanc Stéphane Turcotte Elisabetta Poluzzi Becky Skidmore Michèle Dugas Patrick Blouin Marie-Pier Déry Carlotta Lunghi Jacinthe Leclerc Cathy Martineau Valérie Carnovale Théo Stéfan Johanie Lépine Laura Jalbert Nataly R Espinoza Suarez Olha Svyntozelska Giraud Ekanmian Daniele Maria Nogueira Pelumi Samuel Akinola Global prevalence of antidepressant drug utilization in the community: protocol for a systematic review BMJ Open |
| title | Global prevalence of antidepressant drug utilization in the community: protocol for a systematic review |
| title_full | Global prevalence of antidepressant drug utilization in the community: protocol for a systematic review |
| title_fullStr | Global prevalence of antidepressant drug utilization in the community: protocol for a systematic review |
| title_full_unstemmed | Global prevalence of antidepressant drug utilization in the community: protocol for a systematic review |
| title_short | Global prevalence of antidepressant drug utilization in the community: protocol for a systematic review |
| title_sort | global prevalence of antidepressant drug utilization in the community protocol for a systematic review |
| url | https://bmjopen.bmj.com/content/12/5/e062197.full |
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