Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study.
<h4>Background</h4>Smoking or weight loss is a risk of tuberculosis (TB) development. However, the impact of weight change after smoking cessation on the occurrence of TB remains elusive. We aimed to determine the relationship between weight change after smoking cessation and the risk of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0266262 |
| _version_ | 1811341782635511808 |
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| author | Seung Hoon Kim Yong-Moon Park Kyungdo Han Seung Hyun Ko Shin Young Kim So Hyang Song Chi Hong Kim Kyu Yeon Hur Sung Kyoung Kim |
| author_facet | Seung Hoon Kim Yong-Moon Park Kyungdo Han Seung Hyun Ko Shin Young Kim So Hyang Song Chi Hong Kim Kyu Yeon Hur Sung Kyoung Kim |
| author_sort | Seung Hoon Kim |
| collection | DOAJ |
| description | <h4>Background</h4>Smoking or weight loss is a risk of tuberculosis (TB) development. However, the impact of weight change after smoking cessation on the occurrence of TB remains elusive. We aimed to determine the relationship between weight change after smoking cessation and the risk of TB development.<h4>Methods</h4>We conducted a population-based cohort study using the national database in Republic of Korea. Of the 10,490,491 subjects who underwent health check-up in 2009, we enrolled 9,953,124 subjects without a previous TB history and followed them until 2017. We divided all study participants into the following three groups: never, former, and current smokers. The primary endpoint was newly developed TB.<h4>Results</h4>Among 9,953,124 subjects analyzed, 5,922,845 (59.5%) were never smokers, 1,428,209 (14.4%) were former smokers, and 2,602,080 (26.1%) were current smokers. The risk of TB development was significantly higher in current smokers than in never smokers (adjusted hazard ratio (aHR) 1.158; 95% confidence interval [CI] 1.131-1.186). Among current smokers, individuals who stopped smoking and maintained weight after baseline evaluation had a significantly lower risk of TB development compared with those who continued to smoke (aHR 0.771; 95% CI 0.741-0.892). However, even after smoking cessation, individuals who lost weight were at a significantly higher risk of TB development compared with those who continued to smoke (aHR 1.327; 95% CI 1.119-1.715).<h4>Conclusions</h4>Our findings suggest that smoking is a risk factor for TB and weight maintenance (neither gaining or losing) after quitting smoking might reduce the risk of TB development. |
| first_indexed | 2024-04-13T18:58:57Z |
| format | Article |
| id | doaj.art-2a3b84f0b6a6457f9e24dada8d89123e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T18:58:57Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2a3b84f0b6a6457f9e24dada8d89123e2022-12-22T02:34:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01174e026626210.1371/journal.pone.0266262Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study.Seung Hoon KimYong-Moon ParkKyungdo HanSeung Hyun KoShin Young KimSo Hyang SongChi Hong KimKyu Yeon HurSung Kyoung Kim<h4>Background</h4>Smoking or weight loss is a risk of tuberculosis (TB) development. However, the impact of weight change after smoking cessation on the occurrence of TB remains elusive. We aimed to determine the relationship between weight change after smoking cessation and the risk of TB development.<h4>Methods</h4>We conducted a population-based cohort study using the national database in Republic of Korea. Of the 10,490,491 subjects who underwent health check-up in 2009, we enrolled 9,953,124 subjects without a previous TB history and followed them until 2017. We divided all study participants into the following three groups: never, former, and current smokers. The primary endpoint was newly developed TB.<h4>Results</h4>Among 9,953,124 subjects analyzed, 5,922,845 (59.5%) were never smokers, 1,428,209 (14.4%) were former smokers, and 2,602,080 (26.1%) were current smokers. The risk of TB development was significantly higher in current smokers than in never smokers (adjusted hazard ratio (aHR) 1.158; 95% confidence interval [CI] 1.131-1.186). Among current smokers, individuals who stopped smoking and maintained weight after baseline evaluation had a significantly lower risk of TB development compared with those who continued to smoke (aHR 0.771; 95% CI 0.741-0.892). However, even after smoking cessation, individuals who lost weight were at a significantly higher risk of TB development compared with those who continued to smoke (aHR 1.327; 95% CI 1.119-1.715).<h4>Conclusions</h4>Our findings suggest that smoking is a risk factor for TB and weight maintenance (neither gaining or losing) after quitting smoking might reduce the risk of TB development.https://doi.org/10.1371/journal.pone.0266262 |
| spellingShingle | Seung Hoon Kim Yong-Moon Park Kyungdo Han Seung Hyun Ko Shin Young Kim So Hyang Song Chi Hong Kim Kyu Yeon Hur Sung Kyoung Kim Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study. PLoS ONE |
| title | Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study. |
| title_full | Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study. |
| title_fullStr | Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study. |
| title_full_unstemmed | Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study. |
| title_short | Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study. |
| title_sort | association of weight change following smoking cessation with the risk of tuberculosis development a nationwide population based cohort study |
| url | https://doi.org/10.1371/journal.pone.0266262 |
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