The orosomucoid 1 protein (α1 acid glycoprotein) is overexpressed in odontogenic myxoma
<p>Abstract</p> <p>Background</p> <p>Odontogenic myxoma (OM) is a benign, but locally invasive, neoplasm occurring in the jaws. However, the molecules implicated in its development are unknown. OM as well as Dental Follicle (DF), an odontogenic tissue surrounding the en...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-08-01
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| Series: | Proteome Science |
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| Online Access: | http://www.proteomesci.com/content/10/1/49 |
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| author | García-Muñoz Alejandro Rodríguez Mario A Bologna-Molina Ronell Cázares-Raga Febe E Hernández-Hernández Fidel C Farfán-Morales J Trujillo Juan J Licéaga-Escalera Carlos Mendoza-Hernández Guillermo |
| author_facet | García-Muñoz Alejandro Rodríguez Mario A Bologna-Molina Ronell Cázares-Raga Febe E Hernández-Hernández Fidel C Farfán-Morales J Trujillo Juan J Licéaga-Escalera Carlos Mendoza-Hernández Guillermo |
| author_sort | García-Muñoz Alejandro |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Odontogenic myxoma (OM) is a benign, but locally invasive, neoplasm occurring in the jaws. However, the molecules implicated in its development are unknown. OM as well as Dental Follicle (DF), an odontogenic tissue surrounding the enamel organ, is derived from ectomesenchymal/mesencyhmal elements. To identify some protein that could participate in the development of this neoplasm, total proteins from OM were separated by two-dimensional electrophoresis and the profiles were compared with those obtained from DF, used as a control.</p> <p>Results</p> <p>We identified eight proteins with differential expression; two of them were downregulated and six upregulated in OM. A spot consistently overexpressed in odontogenic myxoma, with a molecular weight of 44-kDa and a <it>pI</it> of 3.5 was identified as the orosomucoid 1 protein. Western blot experiments confirmed the overexpression of this protein in odontogenic myxoma and immunohistochemical assays showed that this protein was mainly located in the cytoplasm of stellate and spindle-shaped cells of this neoplasm.</p> <p>Conclusion</p> <p>Orosomucoid 1, which belongs to a group of acute-phase proteins, may play a role in the modulation of the immune system and possibly it influences the development of OM.</p> |
| first_indexed | 2024-04-14T01:46:41Z |
| format | Article |
| id | doaj.art-2a3bfcf2bf0c4771bbf7f72d06b5fbbc |
| institution | Directory Open Access Journal |
| issn | 1477-5956 |
| language | English |
| last_indexed | 2024-04-14T01:46:41Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Proteome Science |
| spelling | doaj.art-2a3bfcf2bf0c4771bbf7f72d06b5fbbc2022-12-22T02:19:29ZengBMCProteome Science1477-59562012-08-011014910.1186/1477-5956-10-49The orosomucoid 1 protein (α1 acid glycoprotein) is overexpressed in odontogenic myxomaGarcía-Muñoz AlejandroRodríguez Mario ABologna-Molina RonellCázares-Raga Febe EHernández-Hernández Fidel CFarfán-Morales JTrujillo Juan JLicéaga-Escalera CarlosMendoza-Hernández Guillermo<p>Abstract</p> <p>Background</p> <p>Odontogenic myxoma (OM) is a benign, but locally invasive, neoplasm occurring in the jaws. However, the molecules implicated in its development are unknown. OM as well as Dental Follicle (DF), an odontogenic tissue surrounding the enamel organ, is derived from ectomesenchymal/mesencyhmal elements. To identify some protein that could participate in the development of this neoplasm, total proteins from OM were separated by two-dimensional electrophoresis and the profiles were compared with those obtained from DF, used as a control.</p> <p>Results</p> <p>We identified eight proteins with differential expression; two of them were downregulated and six upregulated in OM. A spot consistently overexpressed in odontogenic myxoma, with a molecular weight of 44-kDa and a <it>pI</it> of 3.5 was identified as the orosomucoid 1 protein. Western blot experiments confirmed the overexpression of this protein in odontogenic myxoma and immunohistochemical assays showed that this protein was mainly located in the cytoplasm of stellate and spindle-shaped cells of this neoplasm.</p> <p>Conclusion</p> <p>Orosomucoid 1, which belongs to a group of acute-phase proteins, may play a role in the modulation of the immune system and possibly it influences the development of OM.</p>http://www.proteomesci.com/content/10/1/49Odontogenic myxomaDental follicleProteomic analysisOrosomucoid 1α1 acid glycoprotein |
| spellingShingle | García-Muñoz Alejandro Rodríguez Mario A Bologna-Molina Ronell Cázares-Raga Febe E Hernández-Hernández Fidel C Farfán-Morales J Trujillo Juan J Licéaga-Escalera Carlos Mendoza-Hernández Guillermo The orosomucoid 1 protein (α1 acid glycoprotein) is overexpressed in odontogenic myxoma Proteome Science Odontogenic myxoma Dental follicle Proteomic analysis Orosomucoid 1 α1 acid glycoprotein |
| title | The orosomucoid 1 protein (α1 acid glycoprotein) is overexpressed in odontogenic myxoma |
| title_full | The orosomucoid 1 protein (α1 acid glycoprotein) is overexpressed in odontogenic myxoma |
| title_fullStr | The orosomucoid 1 protein (α1 acid glycoprotein) is overexpressed in odontogenic myxoma |
| title_full_unstemmed | The orosomucoid 1 protein (α1 acid glycoprotein) is overexpressed in odontogenic myxoma |
| title_short | The orosomucoid 1 protein (α1 acid glycoprotein) is overexpressed in odontogenic myxoma |
| title_sort | orosomucoid 1 protein α1 acid glycoprotein is overexpressed in odontogenic myxoma |
| topic | Odontogenic myxoma Dental follicle Proteomic analysis Orosomucoid 1 α1 acid glycoprotein |
| url | http://www.proteomesci.com/content/10/1/49 |
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