Spectroscopic, anti-bacterial, anti-cancer and molecular docking of Pd(II) and Pt(II) complexes with (E)-4-((dimethylamino)methyl)-2-((4,5-dimethylthiazol-2-yl)diazenyl)phenol ligand
New ligand (E)-4-((dimethylamino)methyl)-2-((4,5-dimethylthiazol-2-yl)diazenyl)phenol (HDmazo) was prepared by the coupling reaction between 4,5-dimethylthiazol-2-amine and 4-((dimethylamino)methyl)phenol. Moreover, the [MCl2(HDmazo)] and [M(HDmazo)2] [MII = Pd and Pt] were prepared using the direct...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Journal of Saudi Chemical Society |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610323000236 |
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| author | Ahmed S.M. Al-Janabi Khulood H. Oudah Samar A. Aldossari Mohamed A. Khalaf Abdulrahman M. Saleh Mohammad R. Hatshan Nourah B. Altheeb Syed Farooq Adil |
| author_facet | Ahmed S.M. Al-Janabi Khulood H. Oudah Samar A. Aldossari Mohamed A. Khalaf Abdulrahman M. Saleh Mohammad R. Hatshan Nourah B. Altheeb Syed Farooq Adil |
| author_sort | Ahmed S.M. Al-Janabi |
| collection | DOAJ |
| description | New ligand (E)-4-((dimethylamino)methyl)-2-((4,5-dimethylthiazol-2-yl)diazenyl)phenol (HDmazo) was prepared by the coupling reaction between 4,5-dimethylthiazol-2-amine and 4-((dimethylamino)methyl)phenol. Moreover, the [MCl2(HDmazo)] and [M(HDmazo)2] [MII = Pd and Pt] were prepared using the direct reaction of equivalent molar of HDmazo and Na2PdCl4 or K2PtCl4. The HDmazo and its complexes were investigated by different spectroscopic techniques. In complexes (1–2) HDmazo ligand behaves as bidentate style through the nitrogen of azo group and nitrogen of thiazole ring towards Pd(II) and Pt(II). Or in a bidentate fashion via the oxygen atom of the hydroxylate group and nitrogen atom of azo group as mono-anion in complexes (3–4). Further, the study of biological activity against four pathogenic bacteria showed that compound (3) exhibited good activity compared to other compounds. Additional the anti-tumor action against A2870 cell lines was screened, and the complexes (1) and (2) displayed good activity with 7.45 ± 0.98 µM and 13.23 ± 1.43 µM, respectively. The binding mechanism of the prepared compounds with EGFR tyrosine kinase, was investigated using molecular docking experiments. |
| first_indexed | 2024-03-13T05:29:09Z |
| format | Article |
| id | doaj.art-2a3ca8203ed047b3ae1294119817e3be |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-03-13T05:29:09Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-2a3ca8203ed047b3ae1294119817e3be2023-06-15T04:54:26ZengElsevierJournal of Saudi Chemical Society1319-61032023-05-01273101619Spectroscopic, anti-bacterial, anti-cancer and molecular docking of Pd(II) and Pt(II) complexes with (E)-4-((dimethylamino)methyl)-2-((4,5-dimethylthiazol-2-yl)diazenyl)phenol ligandAhmed S.M. Al-Janabi0Khulood H. Oudah1Samar A. Aldossari2Mohamed A. Khalaf3Abdulrahman M. Saleh4Mohammad R. Hatshan5Nourah B. Altheeb6Syed Farooq Adil7Department of Chemistry, College of Science, Tikrit University, Tikrit, Iraq; Corresponding authors.Pharmaceutical Chemistry Department, College of Pharmacy, Al-Ayen University, Thi-Qar, IraqDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, College of Science, United Arab Emirates University, P. O. Box 15551, Al Ain, United Arab EmiratesPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, EgyptDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; Corresponding authors.New ligand (E)-4-((dimethylamino)methyl)-2-((4,5-dimethylthiazol-2-yl)diazenyl)phenol (HDmazo) was prepared by the coupling reaction between 4,5-dimethylthiazol-2-amine and 4-((dimethylamino)methyl)phenol. Moreover, the [MCl2(HDmazo)] and [M(HDmazo)2] [MII = Pd and Pt] were prepared using the direct reaction of equivalent molar of HDmazo and Na2PdCl4 or K2PtCl4. The HDmazo and its complexes were investigated by different spectroscopic techniques. In complexes (1–2) HDmazo ligand behaves as bidentate style through the nitrogen of azo group and nitrogen of thiazole ring towards Pd(II) and Pt(II). Or in a bidentate fashion via the oxygen atom of the hydroxylate group and nitrogen atom of azo group as mono-anion in complexes (3–4). Further, the study of biological activity against four pathogenic bacteria showed that compound (3) exhibited good activity compared to other compounds. Additional the anti-tumor action against A2870 cell lines was screened, and the complexes (1) and (2) displayed good activity with 7.45 ± 0.98 µM and 13.23 ± 1.43 µM, respectively. The binding mechanism of the prepared compounds with EGFR tyrosine kinase, was investigated using molecular docking experiments.http://www.sciencedirect.com/science/article/pii/S1319610323000236Azo dyeThiazoleBiological activityMolecular dockingPalladiumPlatinum |
| spellingShingle | Ahmed S.M. Al-Janabi Khulood H. Oudah Samar A. Aldossari Mohamed A. Khalaf Abdulrahman M. Saleh Mohammad R. Hatshan Nourah B. Altheeb Syed Farooq Adil Spectroscopic, anti-bacterial, anti-cancer and molecular docking of Pd(II) and Pt(II) complexes with (E)-4-((dimethylamino)methyl)-2-((4,5-dimethylthiazol-2-yl)diazenyl)phenol ligand Journal of Saudi Chemical Society Azo dye Thiazole Biological activity Molecular docking Palladium Platinum |
| title | Spectroscopic, anti-bacterial, anti-cancer and molecular docking of Pd(II) and Pt(II) complexes with (E)-4-((dimethylamino)methyl)-2-((4,5-dimethylthiazol-2-yl)diazenyl)phenol ligand |
| title_full | Spectroscopic, anti-bacterial, anti-cancer and molecular docking of Pd(II) and Pt(II) complexes with (E)-4-((dimethylamino)methyl)-2-((4,5-dimethylthiazol-2-yl)diazenyl)phenol ligand |
| title_fullStr | Spectroscopic, anti-bacterial, anti-cancer and molecular docking of Pd(II) and Pt(II) complexes with (E)-4-((dimethylamino)methyl)-2-((4,5-dimethylthiazol-2-yl)diazenyl)phenol ligand |
| title_full_unstemmed | Spectroscopic, anti-bacterial, anti-cancer and molecular docking of Pd(II) and Pt(II) complexes with (E)-4-((dimethylamino)methyl)-2-((4,5-dimethylthiazol-2-yl)diazenyl)phenol ligand |
| title_short | Spectroscopic, anti-bacterial, anti-cancer and molecular docking of Pd(II) and Pt(II) complexes with (E)-4-((dimethylamino)methyl)-2-((4,5-dimethylthiazol-2-yl)diazenyl)phenol ligand |
| title_sort | spectroscopic anti bacterial anti cancer and molecular docking of pd ii and pt ii complexes with e 4 dimethylamino methyl 2 4 5 dimethylthiazol 2 yl diazenyl phenol ligand |
| topic | Azo dye Thiazole Biological activity Molecular docking Palladium Platinum |
| url | http://www.sciencedirect.com/science/article/pii/S1319610323000236 |
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