Genomic characterization of a repetitive motif strongly associated with developmental genes in <it>Drosophila</it>
<p>Abstract</p> <p>Background</p> <p>Non-coding DNA represents a high proportion of all metazoan genomes. Although an undetermined fraction of this DNA may be considered devoid of any function, it also contains important information residing in specific <it>cis<...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2003-12-01
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| Series: | BMC Genomics |
| Online Access: | http://www.biomedcentral.com/1471-2164/4/52 |
| _version_ | 1811279275724111872 |
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| author | Vieira Cristina P Costas Javier Casares Fernando Vieira Jorge |
| author_facet | Vieira Cristina P Costas Javier Casares Fernando Vieira Jorge |
| author_sort | Vieira Cristina P |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Non-coding DNA represents a high proportion of all metazoan genomes. Although an undetermined fraction of this DNA may be considered devoid of any function, it also contains important information residing in specific <it>cis</it>-regulatory sequences.</p> <p>Results</p> <p>We report a 27 bp motif that is overrepresented within the fly genome. This motif does not show any significant similarity with transposon sequences and is strongly associated with genes involved in development and/or signal transduction. The 27 bp motif is preferentially located within introns, and has a tendency to be present in multiple copies around genes. Furthermore, it is often found embedded in known non-coding regulatory regions. The regulatory network defined by this motif is partially shared in <it>D. pseudoobscura</it>.</p> <p>Conclusion</p> <p>We have identified a 27 bp <it>cis</it>-regulatory sequence widely distributed within the <it>Drosophila </it>genome in association with developmental genes. This motif may be very useful towards the annotation of functional regulatory regions within the <it>Drosophila </it>genome and the construction of regulatory networks of <it>Drosophila </it>development.</p> |
| first_indexed | 2024-04-13T00:51:49Z |
| format | Article |
| id | doaj.art-2a3ecee39b0d4df79592a032db149ac1 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-04-13T00:51:49Z |
| publishDate | 2003-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-2a3ecee39b0d4df79592a032db149ac12022-12-22T03:09:50ZengBMCBMC Genomics1471-21642003-12-01415210.1186/1471-2164-4-52Genomic characterization of a repetitive motif strongly associated with developmental genes in <it>Drosophila</it>Vieira Cristina PCostas JavierCasares FernandoVieira Jorge<p>Abstract</p> <p>Background</p> <p>Non-coding DNA represents a high proportion of all metazoan genomes. Although an undetermined fraction of this DNA may be considered devoid of any function, it also contains important information residing in specific <it>cis</it>-regulatory sequences.</p> <p>Results</p> <p>We report a 27 bp motif that is overrepresented within the fly genome. This motif does not show any significant similarity with transposon sequences and is strongly associated with genes involved in development and/or signal transduction. The 27 bp motif is preferentially located within introns, and has a tendency to be present in multiple copies around genes. Furthermore, it is often found embedded in known non-coding regulatory regions. The regulatory network defined by this motif is partially shared in <it>D. pseudoobscura</it>.</p> <p>Conclusion</p> <p>We have identified a 27 bp <it>cis</it>-regulatory sequence widely distributed within the <it>Drosophila </it>genome in association with developmental genes. This motif may be very useful towards the annotation of functional regulatory regions within the <it>Drosophila </it>genome and the construction of regulatory networks of <it>Drosophila </it>development.</p>http://www.biomedcentral.com/1471-2164/4/52 |
| spellingShingle | Vieira Cristina P Costas Javier Casares Fernando Vieira Jorge Genomic characterization of a repetitive motif strongly associated with developmental genes in <it>Drosophila</it> BMC Genomics |
| title | Genomic characterization of a repetitive motif strongly associated with developmental genes in <it>Drosophila</it> |
| title_full | Genomic characterization of a repetitive motif strongly associated with developmental genes in <it>Drosophila</it> |
| title_fullStr | Genomic characterization of a repetitive motif strongly associated with developmental genes in <it>Drosophila</it> |
| title_full_unstemmed | Genomic characterization of a repetitive motif strongly associated with developmental genes in <it>Drosophila</it> |
| title_short | Genomic characterization of a repetitive motif strongly associated with developmental genes in <it>Drosophila</it> |
| title_sort | genomic characterization of a repetitive motif strongly associated with developmental genes in it drosophila it |
| url | http://www.biomedcentral.com/1471-2164/4/52 |
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