Synthesis of nickel cobalt-codoped tin oxide nanoparticles from Psidium guajava with anticancer properties
Metal oxide nanoparticles have been found to selectively target the tumor cells while non-toxic to the normal cells. Leukemia is one of the widespread and deadly cancers in adults, as well as the most common cancer in children. Recently, the nanoparticles have evolved as a simple, economic, effectiv...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535222007973 |
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| author | Abozer Y. Elderdery Badr Alzahrani Abdulrahim A. Alabdulsalam Fehaid Alanazi Siddiqa M A Hamza Ahmed M E Elkhalifa Abdulaziz H. Alhamidi A. Mohamedain Suresh Kumar Subbiah Pooi Ling Mok |
| author_facet | Abozer Y. Elderdery Badr Alzahrani Abdulrahim A. Alabdulsalam Fehaid Alanazi Siddiqa M A Hamza Ahmed M E Elkhalifa Abdulaziz H. Alhamidi A. Mohamedain Suresh Kumar Subbiah Pooi Ling Mok |
| author_sort | Abozer Y. Elderdery |
| collection | DOAJ |
| description | Metal oxide nanoparticles have been found to selectively target the tumor cells while non-toxic to the normal cells. Leukemia is one of the widespread and deadly cancers in adults, as well as the most common cancer in children. Recently, the nanoparticles have evolved as a simple, economic, effective, and ecologically sound strategy among the known nanoparticle synthesis techniques. In the present study, the structural, optical, and antibacterial effects of nickel cobalt-codoped Tin oxide nanoparticles (SnNiCoO2 NPs) formulated by the green process and the anticancer potential of SnNiCoO2 NPs in Molt-4 cells have been studied. The cytotoxic potential of the NPs against Molt-4 cells was estimated by MTT assay. The ROS and MMP levels were measured using fluorescent dyes and the changes in morphology and nuclei were noted using AO/EB staining. CAT, SOD, MDA, and GSH), and Proinflammatory Cytokines (TNF-α and IL1β) were also studied. The activity of caspase-3, −9, and −8 levels was examined to analyze the apoptotic mechanism. The XRD patterns of SnNiCoO2 NPs revealed a tetragonal structure. The SnNiCoO2 NPs was revealed a diameter of 126 nm by the DLS study. The morphology and elemental composition were studied using FESEM and EDAX spectra. In the FT-IR study, the O-sn-O stretching band was found to be 615 and 542 cm-1. The antimicrobial potential of the SnNiCoO2 NPs was examined against S. aureus, E. coli, and C. Albicans strains. A tremendous reduction in the viability of MOLT-4 cells at concentration-dependent mode witnessed the cytotoxic potential of the formulated NPs. The augmented ROS accumulation, depletion of MMP status, depleted antioxidants, and increased proinflammatory cytokines (TNF-α and IL1β) were noted on the NPs exposed cells. Furthermore, the increased expressions of caspase-3, −9, and −8 was also noted in the NPs treated MOLT-4 cells. Hence, the outcomes suggest that the formulated SnNiCoO2 NPs had remarkably potent antimicrobial and anticancer properties and could potentially prove beneficial in cancer treatment. Induces mitochondrial oxidative stress with nickel–cobalt-codoped tin oxide nanoparticles from Psidium guajava, which is a potential drug candidate for the antibiotic, antifungal, and anticancer activities of plant-based nanoparticles. |
| first_indexed | 2024-04-10T22:52:17Z |
| format | Article |
| id | doaj.art-2a3fa06d9fce4bd88588be015a12eddb |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-10T22:52:17Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-2a3fa06d9fce4bd88588be015a12eddb2023-01-15T04:21:40ZengElsevierArabian Journal of Chemistry1878-53522023-02-01162104481Synthesis of nickel cobalt-codoped tin oxide nanoparticles from Psidium guajava with anticancer propertiesAbozer Y. Elderdery0Badr Alzahrani1Abdulrahim A. Alabdulsalam2Fehaid Alanazi3Siddiqa M A Hamza4Ahmed M E Elkhalifa5Abdulaziz H. Alhamidi6A. Mohamedain7Suresh Kumar Subbiah8Pooi Ling Mok9Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia; Health Sciences Research Unit, Jouf University, Sakaka, Saudi Arabia; Corresponding author at: Jouf University, Saudi Arabia.Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi ArabiaDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Alhofuf, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences-AlQurayyat, Jouf University, Saudi ArabiaFaculty of Medicine, Department of Pathology, Umm Alqura University, Algunfuda, Saudi ArabiaDepartment of Public Health, College of Health Sciences, Saudi Electronic University, Riyadh, Saudi Arabia; Department of Haematology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, SudanClinical Laboratory Sciences Department, College of Applied Medical Science, King Saud University, Riyadh, Saudi ArabiaDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Alhofuf, Saudi Arabia; Department of Biochemistry, Faculty of Medicine, Khartoum University, SudanCentre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research, Chennai, IndiaDepartment of Biomedical Sciences, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaMetal oxide nanoparticles have been found to selectively target the tumor cells while non-toxic to the normal cells. Leukemia is one of the widespread and deadly cancers in adults, as well as the most common cancer in children. Recently, the nanoparticles have evolved as a simple, economic, effective, and ecologically sound strategy among the known nanoparticle synthesis techniques. In the present study, the structural, optical, and antibacterial effects of nickel cobalt-codoped Tin oxide nanoparticles (SnNiCoO2 NPs) formulated by the green process and the anticancer potential of SnNiCoO2 NPs in Molt-4 cells have been studied. The cytotoxic potential of the NPs against Molt-4 cells was estimated by MTT assay. The ROS and MMP levels were measured using fluorescent dyes and the changes in morphology and nuclei were noted using AO/EB staining. CAT, SOD, MDA, and GSH), and Proinflammatory Cytokines (TNF-α and IL1β) were also studied. The activity of caspase-3, −9, and −8 levels was examined to analyze the apoptotic mechanism. The XRD patterns of SnNiCoO2 NPs revealed a tetragonal structure. The SnNiCoO2 NPs was revealed a diameter of 126 nm by the DLS study. The morphology and elemental composition were studied using FESEM and EDAX spectra. In the FT-IR study, the O-sn-O stretching band was found to be 615 and 542 cm-1. The antimicrobial potential of the SnNiCoO2 NPs was examined against S. aureus, E. coli, and C. Albicans strains. A tremendous reduction in the viability of MOLT-4 cells at concentration-dependent mode witnessed the cytotoxic potential of the formulated NPs. The augmented ROS accumulation, depletion of MMP status, depleted antioxidants, and increased proinflammatory cytokines (TNF-α and IL1β) were noted on the NPs exposed cells. Furthermore, the increased expressions of caspase-3, −9, and −8 was also noted in the NPs treated MOLT-4 cells. Hence, the outcomes suggest that the formulated SnNiCoO2 NPs had remarkably potent antimicrobial and anticancer properties and could potentially prove beneficial in cancer treatment. Induces mitochondrial oxidative stress with nickel–cobalt-codoped tin oxide nanoparticles from Psidium guajava, which is a potential drug candidate for the antibiotic, antifungal, and anticancer activities of plant-based nanoparticles.http://www.sciencedirect.com/science/article/pii/S1878535222007973Acute lymphoblastic leukemia (ALL)AntibacterialAnticancerGreen SynthesisPsidium guajavaSnNiCoO2 NPs |
| spellingShingle | Abozer Y. Elderdery Badr Alzahrani Abdulrahim A. Alabdulsalam Fehaid Alanazi Siddiqa M A Hamza Ahmed M E Elkhalifa Abdulaziz H. Alhamidi A. Mohamedain Suresh Kumar Subbiah Pooi Ling Mok Synthesis of nickel cobalt-codoped tin oxide nanoparticles from Psidium guajava with anticancer properties Arabian Journal of Chemistry Acute lymphoblastic leukemia (ALL) Antibacterial Anticancer Green Synthesis Psidium guajava SnNiCoO2 NPs |
| title | Synthesis of nickel cobalt-codoped tin oxide nanoparticles from Psidium guajava with anticancer properties |
| title_full | Synthesis of nickel cobalt-codoped tin oxide nanoparticles from Psidium guajava with anticancer properties |
| title_fullStr | Synthesis of nickel cobalt-codoped tin oxide nanoparticles from Psidium guajava with anticancer properties |
| title_full_unstemmed | Synthesis of nickel cobalt-codoped tin oxide nanoparticles from Psidium guajava with anticancer properties |
| title_short | Synthesis of nickel cobalt-codoped tin oxide nanoparticles from Psidium guajava with anticancer properties |
| title_sort | synthesis of nickel cobalt codoped tin oxide nanoparticles from psidium guajava with anticancer properties |
| topic | Acute lymphoblastic leukemia (ALL) Antibacterial Anticancer Green Synthesis Psidium guajava SnNiCoO2 NPs |
| url | http://www.sciencedirect.com/science/article/pii/S1878535222007973 |
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