Ribosylation rapidly induces alpha-synuclein to form highly cytotoxic molten globules of advanced glycation end products.
BACKGROUND: Alpha synuclein (alpha-Syn) is the main component of Lewy bodies which are associated with several neurodegenerative diseases such as Parkinson's disease. While the glycation with D-glucose that results in alpha-Syn misfold and aggregation has been studied, the effects of glycation...
| Main Authors: | , , , |
|---|---|
| 格式: | Article |
| 語言: | English |
| 出版: |
Public Library of Science (PLoS)
2010-01-01
|
| 叢編: | PLoS ONE |
| 在線閱讀: | http://europepmc.org/articles/PMC2816216?pdf=render |