Ribosylation rapidly induces alpha-synuclein to form highly cytotoxic molten globules of advanced glycation end products.
BACKGROUND: Alpha synuclein (alpha-Syn) is the main component of Lewy bodies which are associated with several neurodegenerative diseases such as Parkinson's disease. While the glycation with D-glucose that results in alpha-Syn misfold and aggregation has been studied, the effects of glycation...
| Glavni autori: | , , , |
|---|---|
| Format: | Članak |
| Jezik: | English |
| Izdano: |
Public Library of Science (PLoS)
2010-01-01
|
| Serija: | PLoS ONE |
| Online pristup: | http://europepmc.org/articles/PMC2816216?pdf=render |