Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol.
Schizophrenia spectrum disorders (SSDs) are associated with significant functional impairments, disability, and low rates of personal recovery, along with tremendous economic costs linked primarily to lost productivity and premature mortality. Efforts to delineate the contributors to disability in S...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0288354 |
| _version_ | 1797671864012636160 |
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| author | Sri Mahavir Agarwal Joel Dissanayake Ofer Agid Christopher Bowie Noah Brierley Araba Chintoh Vincenzo De Luca Andreea Diaconescu Philip Gerretsen Ariel Graff-Guerrero Colin Hawco Yarissa Herman Sean Hill Kathryn Hum Muhammad Omair Husain James L Kennedy Michael Kiang Sean Kidd Nicole Kozloff Marta Maslej Daniel J Mueller Farooq Naeem Nicholas Neufeld Gary Remington Martin Rotenberg Peter Selby Ishraq Siddiqui Kate Szacun-Shimizu Arun K Tiwari Shanthos Thirunavukkarasu Wei Wang Joanna Yu Clement C Zai Robert Zipursky Margaret Hahn George Foussias |
| author_facet | Sri Mahavir Agarwal Joel Dissanayake Ofer Agid Christopher Bowie Noah Brierley Araba Chintoh Vincenzo De Luca Andreea Diaconescu Philip Gerretsen Ariel Graff-Guerrero Colin Hawco Yarissa Herman Sean Hill Kathryn Hum Muhammad Omair Husain James L Kennedy Michael Kiang Sean Kidd Nicole Kozloff Marta Maslej Daniel J Mueller Farooq Naeem Nicholas Neufeld Gary Remington Martin Rotenberg Peter Selby Ishraq Siddiqui Kate Szacun-Shimizu Arun K Tiwari Shanthos Thirunavukkarasu Wei Wang Joanna Yu Clement C Zai Robert Zipursky Margaret Hahn George Foussias |
| author_sort | Sri Mahavir Agarwal |
| collection | DOAJ |
| description | Schizophrenia spectrum disorders (SSDs) are associated with significant functional impairments, disability, and low rates of personal recovery, along with tremendous economic costs linked primarily to lost productivity and premature mortality. Efforts to delineate the contributors to disability in SSDs have highlighted prominent roles for a diverse range of symptoms, physical health conditions, substance use disorders, neurobiological changes, and social factors. These findings have provided valuable advances in knowledge and helped define broad patterns of illness and outcomes across SSDs. Unsurprisingly, there have also been conflicting findings for many of these determinants that reflect the heterogeneous population of individuals with SSDs and the challenges of conceptualizing and treating SSDs as a unitary categorical construct. Presently it is not possible to identify the functional course on an individual level that would enable a personalized approach to treatment to alter the individual's functional trajectory and mitigate the ensuing disability they would otherwise experience. To address this ongoing challenge, this study aims to conduct a longitudinal multimodal investigation of a large cohort of individuals with SSDs in order to establish discrete trajectories of personal recovery, disability, and community functioning, as well as the antecedents and predictors of these trajectories. This investigation will also provide the foundation for the co-design and testing of personalized interventions that alter these functional trajectories and improve outcomes for people with SSDs. |
| first_indexed | 2024-03-11T21:21:41Z |
| format | Article |
| id | doaj.art-2a424a7d83be45218cd7cca45642f02a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-11T21:21:41Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2a424a7d83be45218cd7cca45642f02a2023-09-28T05:31:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01189e028835410.1371/journal.pone.0288354Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol.Sri Mahavir AgarwalJoel DissanayakeOfer AgidChristopher BowieNoah BrierleyAraba ChintohVincenzo De LucaAndreea DiaconescuPhilip GerretsenAriel Graff-GuerreroColin HawcoYarissa HermanSean HillKathryn HumMuhammad Omair HusainJames L KennedyMichael KiangSean KiddNicole KozloffMarta MaslejDaniel J MuellerFarooq NaeemNicholas NeufeldGary RemingtonMartin RotenbergPeter SelbyIshraq SiddiquiKate Szacun-ShimizuArun K TiwariShanthos ThirunavukkarasuWei WangJoanna YuClement C ZaiRobert ZipurskyMargaret HahnGeorge FoussiasSchizophrenia spectrum disorders (SSDs) are associated with significant functional impairments, disability, and low rates of personal recovery, along with tremendous economic costs linked primarily to lost productivity and premature mortality. Efforts to delineate the contributors to disability in SSDs have highlighted prominent roles for a diverse range of symptoms, physical health conditions, substance use disorders, neurobiological changes, and social factors. These findings have provided valuable advances in knowledge and helped define broad patterns of illness and outcomes across SSDs. Unsurprisingly, there have also been conflicting findings for many of these determinants that reflect the heterogeneous population of individuals with SSDs and the challenges of conceptualizing and treating SSDs as a unitary categorical construct. Presently it is not possible to identify the functional course on an individual level that would enable a personalized approach to treatment to alter the individual's functional trajectory and mitigate the ensuing disability they would otherwise experience. To address this ongoing challenge, this study aims to conduct a longitudinal multimodal investigation of a large cohort of individuals with SSDs in order to establish discrete trajectories of personal recovery, disability, and community functioning, as well as the antecedents and predictors of these trajectories. This investigation will also provide the foundation for the co-design and testing of personalized interventions that alter these functional trajectories and improve outcomes for people with SSDs.https://doi.org/10.1371/journal.pone.0288354 |
| spellingShingle | Sri Mahavir Agarwal Joel Dissanayake Ofer Agid Christopher Bowie Noah Brierley Araba Chintoh Vincenzo De Luca Andreea Diaconescu Philip Gerretsen Ariel Graff-Guerrero Colin Hawco Yarissa Herman Sean Hill Kathryn Hum Muhammad Omair Husain James L Kennedy Michael Kiang Sean Kidd Nicole Kozloff Marta Maslej Daniel J Mueller Farooq Naeem Nicholas Neufeld Gary Remington Martin Rotenberg Peter Selby Ishraq Siddiqui Kate Szacun-Shimizu Arun K Tiwari Shanthos Thirunavukkarasu Wei Wang Joanna Yu Clement C Zai Robert Zipursky Margaret Hahn George Foussias Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol. PLoS ONE |
| title | Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol. |
| title_full | Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol. |
| title_fullStr | Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol. |
| title_full_unstemmed | Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol. |
| title_short | Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol. |
| title_sort | characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders predicts study study protocol |
| url | https://doi.org/10.1371/journal.pone.0288354 |
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