Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon
The cryo-EM structure of the type VK CRISPR-associated TnsB transposase sheds light onto RNA-guided transposition, providing new possibilities to redesign CRISPR-associated transposon systems.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33504-5 |
| _version_ | 1818025973138849792 |
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| author | Francisco Tenjo-Castaño Nicholas Sofos Blanca López-Méndez Luisa S. Stutzke Anders Fuglsang Stefano Stella Guillermo Montoya |
| author_facet | Francisco Tenjo-Castaño Nicholas Sofos Blanca López-Méndez Luisa S. Stutzke Anders Fuglsang Stefano Stella Guillermo Montoya |
| author_sort | Francisco Tenjo-Castaño |
| collection | DOAJ |
| description | The cryo-EM structure of the type VK CRISPR-associated TnsB transposase sheds light onto RNA-guided transposition, providing new possibilities to redesign CRISPR-associated transposon systems. |
| first_indexed | 2024-12-10T04:24:37Z |
| format | Article |
| id | doaj.art-2a440988650d42a0ba6153e6e62f9a5d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T04:24:37Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2a440988650d42a0ba6153e6e62f9a5d2022-12-22T02:02:18ZengNature PortfolioNature Communications2041-17232022-10-0113111410.1038/s41467-022-33504-5Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposonFrancisco Tenjo-Castaño0Nicholas Sofos1Blanca López-Méndez2Luisa S. Stutzke3Anders Fuglsang4Stefano Stella5Guillermo Montoya6Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of CopenhagenStructural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of CopenhagenProtein Purification and Characterisation Facility, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of CopenhagenStructural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of CopenhagenStructural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of CopenhagenStructural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of CopenhagenStructural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of CopenhagenThe cryo-EM structure of the type VK CRISPR-associated TnsB transposase sheds light onto RNA-guided transposition, providing new possibilities to redesign CRISPR-associated transposon systems.https://doi.org/10.1038/s41467-022-33504-5 |
| spellingShingle | Francisco Tenjo-Castaño Nicholas Sofos Blanca López-Méndez Luisa S. Stutzke Anders Fuglsang Stefano Stella Guillermo Montoya Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon Nature Communications |
| title | Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon |
| title_full | Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon |
| title_fullStr | Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon |
| title_full_unstemmed | Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon |
| title_short | Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon |
| title_sort | structure of the tnsb transposase dna complex of type v k crispr associated transposon |
| url | https://doi.org/10.1038/s41467-022-33504-5 |
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