Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral Mucositis
Stomatitis is occasionally multiple, recurrent, and refractory. Currently, mucositis induced by chemotherapy and radiation therapy in patients with cancer has become a significant clinical problem. Effective treatments have not been established and the treatment of numerous cases remains a challenge...
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MDPI AG
2018-12-01
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| Series: | Medicines |
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| Online Access: | https://www.mdpi.com/2305-6320/5/4/130 |
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| author | Masataka Sunagawa Kojiro Yamaguchi Mana Tsukada Nachi Ebihara Hideshi Ikemoto Tadashi Hisamitsu |
| author_facet | Masataka Sunagawa Kojiro Yamaguchi Mana Tsukada Nachi Ebihara Hideshi Ikemoto Tadashi Hisamitsu |
| author_sort | Masataka Sunagawa |
| collection | DOAJ |
| description | Stomatitis is occasionally multiple, recurrent, and refractory. Currently, mucositis induced by chemotherapy and radiation therapy in patients with cancer has become a significant clinical problem. Effective treatments have not been established and the treatment of numerous cases remains a challenge for physicians. Traditional Japanese herbal medicines termed Kampo formulae (i.e., Hangeshashinto, Orengedokuto, Inchinkoto, Orento, Byakkokaninjinto, Juzentaihoto, Hochuekkito, and Shosaikoto) are used for treating various types of stomatitis and mucositis. Its use has been based on the Kampo medical theories—empirical rules established over thousands of years. However, recently, clinical and basic research studies investigating these formulae have been conducted to obtain scientific evidence. Clinical studies investigating efficacies of Shosaikoto and Orento for the treatment of cryptogenic stomatitis and acute aphthous stomatitis and those investigating the effects of Hangeshashinto, Orengedokuto, and Juzentaihoto on chemotherapy- or radiotherapy-induced mucositis have been conducted. The Kampo formulae comprise several crude drugs, whose mechanisms of action are gradually being clarified. Most of these drugs that are used for the treatment of stomatitis possess anti-inflammatory, analgesic, and antioxidative properties. In this review, we introduce the clinical applications and summarize the available evidence on the Kampo formulae for the treatment of stomatitis and oral mucositis. |
| first_indexed | 2024-12-11T20:13:36Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2305-6320 |
| language | English |
| last_indexed | 2024-12-11T20:13:36Z |
| publishDate | 2018-12-01 |
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| series | Medicines |
| spelling | doaj.art-2a452b43e7714dcbb458e1fd41b001e22022-12-22T00:52:15ZengMDPI AGMedicines2305-63202018-12-015413010.3390/medicines5040130medicines5040130Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral MucositisMasataka Sunagawa0Kojiro Yamaguchi1Mana Tsukada2Nachi Ebihara3Hideshi Ikemoto4Tadashi Hisamitsu5Department of physiology, School of medicine, Showa University, Tokyo 142-8555, JapanDepartment of physiology, School of medicine, Showa University, Tokyo 142-8555, JapanDepartment of physiology, School of medicine, Showa University, Tokyo 142-8555, JapanDepartment of physiology, School of medicine, Showa University, Tokyo 142-8555, JapanDepartment of physiology, School of medicine, Showa University, Tokyo 142-8555, JapanDepartment of physiology, School of medicine, Showa University, Tokyo 142-8555, JapanStomatitis is occasionally multiple, recurrent, and refractory. Currently, mucositis induced by chemotherapy and radiation therapy in patients with cancer has become a significant clinical problem. Effective treatments have not been established and the treatment of numerous cases remains a challenge for physicians. Traditional Japanese herbal medicines termed Kampo formulae (i.e., Hangeshashinto, Orengedokuto, Inchinkoto, Orento, Byakkokaninjinto, Juzentaihoto, Hochuekkito, and Shosaikoto) are used for treating various types of stomatitis and mucositis. Its use has been based on the Kampo medical theories—empirical rules established over thousands of years. However, recently, clinical and basic research studies investigating these formulae have been conducted to obtain scientific evidence. Clinical studies investigating efficacies of Shosaikoto and Orento for the treatment of cryptogenic stomatitis and acute aphthous stomatitis and those investigating the effects of Hangeshashinto, Orengedokuto, and Juzentaihoto on chemotherapy- or radiotherapy-induced mucositis have been conducted. The Kampo formulae comprise several crude drugs, whose mechanisms of action are gradually being clarified. Most of these drugs that are used for the treatment of stomatitis possess anti-inflammatory, analgesic, and antioxidative properties. In this review, we introduce the clinical applications and summarize the available evidence on the Kampo formulae for the treatment of stomatitis and oral mucositis.https://www.mdpi.com/2305-6320/5/4/130kampo formulatraditional Japanese herbal medicinestomatitismucositisHangeshashinto |
| spellingShingle | Masataka Sunagawa Kojiro Yamaguchi Mana Tsukada Nachi Ebihara Hideshi Ikemoto Tadashi Hisamitsu Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral Mucositis Medicines kampo formula traditional Japanese herbal medicine stomatitis mucositis Hangeshashinto |
| title | Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral Mucositis |
| title_full | Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral Mucositis |
| title_fullStr | Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral Mucositis |
| title_full_unstemmed | Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral Mucositis |
| title_short | Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral Mucositis |
| title_sort | kampo traditional japanese herbal formulae for treatment of stomatitis and oral mucositis |
| topic | kampo formula traditional Japanese herbal medicine stomatitis mucositis Hangeshashinto |
| url | https://www.mdpi.com/2305-6320/5/4/130 |
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