Cytoskeleton as an Emerging Target of Anthrax Toxins
Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we p...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-02-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/4/2/83/ |
| _version_ | 1798034035260260352 |
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| author | Jean-Nicolas Tournier Yannick Trescos |
| author_facet | Jean-Nicolas Tournier Yannick Trescos |
| author_sort | Jean-Nicolas Tournier |
| collection | DOAJ |
| description | Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we provide an overview on the general effects of toxin upon the cytoskeleton architecture. Thus, we shall discuss how anthrax toxins interact with their receptors and may disrupt the interface between extracellular matrix and the cytoskeleton. We then analyze what toxin molecular effects on cytoskeleton have been described, before discussing how the cytoskeleton may help the pathogen to corrupt general cell processes such as phagocytosis or vascular integrity. |
| first_indexed | 2024-04-11T20:38:37Z |
| format | Article |
| id | doaj.art-2a4711dcb6b642ef94d217d0832d8ece |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T20:38:37Z |
| publishDate | 2012-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-2a4711dcb6b642ef94d217d0832d8ece2022-12-22T04:04:18ZengMDPI AGToxins2072-66512012-02-0142839710.3390/toxins4020083Cytoskeleton as an Emerging Target of Anthrax ToxinsJean-Nicolas TournierYannick TrescosBacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we provide an overview on the general effects of toxin upon the cytoskeleton architecture. Thus, we shall discuss how anthrax toxins interact with their receptors and may disrupt the interface between extracellular matrix and the cytoskeleton. We then analyze what toxin molecular effects on cytoskeleton have been described, before discussing how the cytoskeleton may help the pathogen to corrupt general cell processes such as phagocytosis or vascular integrity.http://www.mdpi.com/2072-6651/4/2/83/: anthrax toxinscytoskeletonactinphagocytosisvascular integrity |
| spellingShingle | Jean-Nicolas Tournier Yannick Trescos Cytoskeleton as an Emerging Target of Anthrax Toxins Toxins : anthrax toxins cytoskeleton actin phagocytosis vascular integrity |
| title | Cytoskeleton as an Emerging Target of Anthrax Toxins |
| title_full | Cytoskeleton as an Emerging Target of Anthrax Toxins |
| title_fullStr | Cytoskeleton as an Emerging Target of Anthrax Toxins |
| title_full_unstemmed | Cytoskeleton as an Emerging Target of Anthrax Toxins |
| title_short | Cytoskeleton as an Emerging Target of Anthrax Toxins |
| title_sort | cytoskeleton as an emerging target of anthrax toxins |
| topic | : anthrax toxins cytoskeleton actin phagocytosis vascular integrity |
| url | http://www.mdpi.com/2072-6651/4/2/83/ |
| work_keys_str_mv | AT jeannicolastournier cytoskeletonasanemergingtargetofanthraxtoxins AT yannicktrescos cytoskeletonasanemergingtargetofanthraxtoxins |