Combination of Chemo- and Biocatalysis: Conversion of Biomethane to Methanol and Formic Acid
In the present day, methanol is mainly produced from methane via reforming processes, but research focuses on alternative production routes. Herein, we present a chemo-/biocatalytic oxidation cascade as a novel process to currently available methods. Starting from synthetic biogas, in the first step...
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MDPI AG
2019-07-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/9/14/2798 |
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| author | Benny Kunkel Dominik Seeburg Tim Peppel Matthias Stier Sebastian Wohlrab |
| author_facet | Benny Kunkel Dominik Seeburg Tim Peppel Matthias Stier Sebastian Wohlrab |
| author_sort | Benny Kunkel |
| collection | DOAJ |
| description | In the present day, methanol is mainly produced from methane via reforming processes, but research focuses on alternative production routes. Herein, we present a chemo-/biocatalytic oxidation cascade as a novel process to currently available methods. Starting from synthetic biogas, in the first step methane was oxidized to formaldehyde over a mesoporous VO<sub>x</sub>/SBA-15 catalyst. In the second step, the produced formaldehyde was disproportionated enzymatically towards methanol and formic acid in equimolar ratio by formaldehyde dismutase (FDM) obtained from <i>Pseudomonas putida</i>. Two processing routes were demonstrated: (a) batch wise operation using free formaldehyde dismutase after accumulating formaldehyde from the first step and (b) continuous operation with immobilized enzymes. Remarkably, the chemo-/biocatalytic oxidation cascades generate methanol in much higher productivity compared to methane monooxygenase (MMO) which, however, directly converts methane. Moreover, production steps for the generation of formic acid were reduced from four to two stages. |
| first_indexed | 2024-12-11T12:41:16Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-12-11T12:41:16Z |
| publishDate | 2019-07-01 |
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| spelling | doaj.art-2a476bbcffbe46fc8dc553ea9eaec36b2022-12-22T01:06:57ZengMDPI AGApplied Sciences2076-34172019-07-01914279810.3390/app9142798app9142798Combination of Chemo- and Biocatalysis: Conversion of Biomethane to Methanol and Formic AcidBenny Kunkel0Dominik Seeburg1Tim Peppel2Matthias Stier3Sebastian Wohlrab4Leibniz Institute for Catalysis at the University of Rostock, Albert-Einstein-Str. 29a, D-18059 Rostock, GermanyLeibniz Institute for Catalysis at the University of Rostock, Albert-Einstein-Str. 29a, D-18059 Rostock, GermanyLeibniz Institute for Catalysis at the University of Rostock, Albert-Einstein-Str. 29a, D-18059 Rostock, GermanyFraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Nobelstraße 12, D-70569 Stuttgart, GermanyLeibniz Institute for Catalysis at the University of Rostock, Albert-Einstein-Str. 29a, D-18059 Rostock, GermanyIn the present day, methanol is mainly produced from methane via reforming processes, but research focuses on alternative production routes. Herein, we present a chemo-/biocatalytic oxidation cascade as a novel process to currently available methods. Starting from synthetic biogas, in the first step methane was oxidized to formaldehyde over a mesoporous VO<sub>x</sub>/SBA-15 catalyst. In the second step, the produced formaldehyde was disproportionated enzymatically towards methanol and formic acid in equimolar ratio by formaldehyde dismutase (FDM) obtained from <i>Pseudomonas putida</i>. Two processing routes were demonstrated: (a) batch wise operation using free formaldehyde dismutase after accumulating formaldehyde from the first step and (b) continuous operation with immobilized enzymes. Remarkably, the chemo-/biocatalytic oxidation cascades generate methanol in much higher productivity compared to methane monooxygenase (MMO) which, however, directly converts methane. Moreover, production steps for the generation of formic acid were reduced from four to two stages.https://www.mdpi.com/2076-3417/9/14/2798selective oxidationmolecular VO<sub>x</sub> catalystsformaldehyde dismutasemethanolformic acid |
| spellingShingle | Benny Kunkel Dominik Seeburg Tim Peppel Matthias Stier Sebastian Wohlrab Combination of Chemo- and Biocatalysis: Conversion of Biomethane to Methanol and Formic Acid Applied Sciences selective oxidation molecular VO<sub>x</sub> catalysts formaldehyde dismutase methanol formic acid |
| title | Combination of Chemo- and Biocatalysis: Conversion of Biomethane to Methanol and Formic Acid |
| title_full | Combination of Chemo- and Biocatalysis: Conversion of Biomethane to Methanol and Formic Acid |
| title_fullStr | Combination of Chemo- and Biocatalysis: Conversion of Biomethane to Methanol and Formic Acid |
| title_full_unstemmed | Combination of Chemo- and Biocatalysis: Conversion of Biomethane to Methanol and Formic Acid |
| title_short | Combination of Chemo- and Biocatalysis: Conversion of Biomethane to Methanol and Formic Acid |
| title_sort | combination of chemo and biocatalysis conversion of biomethane to methanol and formic acid |
| topic | selective oxidation molecular VO<sub>x</sub> catalysts formaldehyde dismutase methanol formic acid |
| url | https://www.mdpi.com/2076-3417/9/14/2798 |
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