Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson’s Disease: An Updated Review
Parkinson’s disease is the most common age-related motoric neurodegenerative disease. In addition to the cardinal motor symptoms of tremor, rigidity, bradykinesia, and postural instability, there are numerous non-motor symptoms as well. Among the non-motor symptoms, autonomic nervous system dysfunct...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/13/3/226 |
| _version_ | 1797540678236897280 |
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| author | Steven D. Mitchell Christos Sidiropoulos |
| author_facet | Steven D. Mitchell Christos Sidiropoulos |
| author_sort | Steven D. Mitchell |
| collection | DOAJ |
| description | Parkinson’s disease is the most common age-related motoric neurodegenerative disease. In addition to the cardinal motor symptoms of tremor, rigidity, bradykinesia, and postural instability, there are numerous non-motor symptoms as well. Among the non-motor symptoms, autonomic nervous system dysfunction is common. Autonomic symptoms associated with Parkinson’s disease include sialorrhea, hyperhidrosis, gastrointestinal dysfunction, and urinary dysfunction. Botulinum neurotoxin has been shown to potentially improve these autonomic symptoms. In this review, the varied uses of botulinum neurotoxin for autonomic dysfunction in Parkinson’s disease are discussed. This review also includes discussion of some additional indications for the use of botulinum neurotoxin in Parkinson’s disease, including pain. |
| first_indexed | 2024-03-10T13:04:36Z |
| format | Article |
| id | doaj.art-2a482e8d30934b3c9281c922486cd7bc |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T13:04:36Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-2a482e8d30934b3c9281c922486cd7bc2023-11-21T11:11:04ZengMDPI AGToxins2072-66512021-03-0113322610.3390/toxins13030226Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson’s Disease: An Updated ReviewSteven D. Mitchell0Christos Sidiropoulos1Department of Neurology, Michigan State University, East Lansing, MI 48824-7015, USADepartment of Neurology, Michigan State University, East Lansing, MI 48824-7015, USAParkinson’s disease is the most common age-related motoric neurodegenerative disease. In addition to the cardinal motor symptoms of tremor, rigidity, bradykinesia, and postural instability, there are numerous non-motor symptoms as well. Among the non-motor symptoms, autonomic nervous system dysfunction is common. Autonomic symptoms associated with Parkinson’s disease include sialorrhea, hyperhidrosis, gastrointestinal dysfunction, and urinary dysfunction. Botulinum neurotoxin has been shown to potentially improve these autonomic symptoms. In this review, the varied uses of botulinum neurotoxin for autonomic dysfunction in Parkinson’s disease are discussed. This review also includes discussion of some additional indications for the use of botulinum neurotoxin in Parkinson’s disease, including pain.https://www.mdpi.com/2072-6651/13/3/226autonomicbotulinum neurotoxinbotulinum toxinnon-motorParkinson’s disease |
| spellingShingle | Steven D. Mitchell Christos Sidiropoulos Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson’s Disease: An Updated Review Toxins autonomic botulinum neurotoxin botulinum toxin non-motor Parkinson’s disease |
| title | Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson’s Disease: An Updated Review |
| title_full | Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson’s Disease: An Updated Review |
| title_fullStr | Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson’s Disease: An Updated Review |
| title_full_unstemmed | Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson’s Disease: An Updated Review |
| title_short | Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson’s Disease: An Updated Review |
| title_sort | therapeutic applications of botulinum neurotoxin for autonomic symptoms in parkinson s disease an updated review |
| topic | autonomic botulinum neurotoxin botulinum toxin non-motor Parkinson’s disease |
| url | https://www.mdpi.com/2072-6651/13/3/226 |
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