Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer

Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer

The murine MC-38 colorectal cancer model is a commonly used model for cancer with high mutational burden, which is sensitive for immune checkpoint immunotherapy. We set out to analyze endogenous CD8+ T cell responses to MC-38 neo-antigens in tumor-bearing mice and after anti-PD-L1 checkpoint therapy...

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Bibliographic Details
Main Authors: Brett J. Hos, Marcel G.M. Camps, Jitske van den Bulk, Elena Tondini, Thomas C. van den Ende, Dina Ruano, Kees Franken, George M.C. Janssen, Arnoud Ru, Dmitri V. Filippov, Ramon Arens, Peter A. van Veelen, Noel Miranda, Ferry Ossendorp
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
neoantigen
immunotherapy
pd-l1
checkpoint
vaccination
whole exome sequencing
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1673125

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