Perioperative Treatment in Resectable Gastric Cancer: Current Perspectives and Future Directions
Gastric cancer (GC) is the fifth-most common cancer worldwide and an important cause of cancer-related-death. The growing knowledge of its molecular pathogenesis has shown that GC is not a single entity, but a constellation of different diseases, each with its own molecular and clinical characterist...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/3/399 |
| _version_ | 1797723386674151424 |
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| author | Angelica Petrillo Luca Pompella Giuseppe Tirino Annalisa Pappalardo Maria Maddalena Laterza Marianna Caterino Michele Orditura Fortunato Ciardiello Eva Lieto Gennaro Galizia Carlo Castoro Ferdinando De Vita |
| author_facet | Angelica Petrillo Luca Pompella Giuseppe Tirino Annalisa Pappalardo Maria Maddalena Laterza Marianna Caterino Michele Orditura Fortunato Ciardiello Eva Lieto Gennaro Galizia Carlo Castoro Ferdinando De Vita |
| author_sort | Angelica Petrillo |
| collection | DOAJ |
| description | Gastric cancer (GC) is the fifth-most common cancer worldwide and an important cause of cancer-related-death. The growing knowledge of its molecular pathogenesis has shown that GC is not a single entity, but a constellation of different diseases, each with its own molecular and clinical characteristics. Currently, surgery represents the only curative approach for localized GC, but only 20% of patients (pts) showed resectable disease at diagnosis and, even in case of curative resection, the prognosis remains poor due to the high rate of disease relapse. In this context, multimodal perioperative approaches were developed in western and eastern countries in order to decrease relapse rates and improve survival. However, there is little consensus about the optimal treatment for non-metastatic GC. In this review, we summarize the current status and future developments of perioperative chemotherapy in resectable GC, attempting to find clear answers to the real problems in clinical practice. |
| first_indexed | 2024-03-12T10:01:09Z |
| format | Article |
| id | doaj.art-2a4abdf460cc4c36b2c54535004a86d9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T10:01:09Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-2a4abdf460cc4c36b2c54535004a86d92023-09-02T11:37:41ZengMDPI AGCancers2072-66942019-03-0111339910.3390/cancers11030399cancers11030399Perioperative Treatment in Resectable Gastric Cancer: Current Perspectives and Future DirectionsAngelica Petrillo0Luca Pompella1Giuseppe Tirino2Annalisa Pappalardo3Maria Maddalena Laterza4Marianna Caterino5Michele Orditura6Fortunato Ciardiello7Eva Lieto8Gennaro Galizia9Carlo Castoro10Ferdinando De Vita11Division of Medical Oncology, Department of Precision Medicine, School of Medicine, University of study of Campania “Luigi Vanvitelli”, Via Pansini n.5, 80131 Naples, ItalyDivision of Medical Oncology, Department of Precision Medicine, School of Medicine, University of study of Campania “Luigi Vanvitelli”, Via Pansini n.5, 80131 Naples, ItalyDivision of Medical Oncology, Department of Precision Medicine, School of Medicine, University of study of Campania “Luigi Vanvitelli”, Via Pansini n.5, 80131 Naples, ItalyDivision of Medical Oncology, Department of Precision Medicine, School of Medicine, University of study of Campania “Luigi Vanvitelli”, Via Pansini n.5, 80131 Naples, ItalyDivision of Medical Oncology, Department of Precision Medicine, School of Medicine, University of study of Campania “Luigi Vanvitelli”, Via Pansini n.5, 80131 Naples, ItalyDivision of Medical Oncology, Department of Precision Medicine, School of Medicine, University of study of Campania “Luigi Vanvitelli”, Via Pansini n.5, 80131 Naples, ItalyDivision of Medical Oncology, Department of Precision Medicine, School of Medicine, University of study of Campania “Luigi Vanvitelli”, Via Pansini n.5, 80131 Naples, ItalyDivision of Medical Oncology, Department of Precision Medicine, School of Medicine, University of study of Campania “Luigi Vanvitelli”, Via Pansini n.5, 80131 Naples, ItalyDivision of GI Tract Surgical Oncology, Department of Surgical Sciences, University of study of Campania “Luigi Vanvitelli”, Via Pansini n.5, 80131 Naples, ItalyDivision of GI Tract Surgical Oncology, Department of Surgical Sciences, University of study of Campania “Luigi Vanvitelli”, Via Pansini n.5, 80131 Naples, ItalyDepartment of upper GI surgery, Humanitas Research Hospital-Humanitas University, 20089 Rozzano (Milano), ItalyDivision of Medical Oncology, Department of Precision Medicine, School of Medicine, University of study of Campania “Luigi Vanvitelli”, Via Pansini n.5, 80131 Naples, ItalyGastric cancer (GC) is the fifth-most common cancer worldwide and an important cause of cancer-related-death. The growing knowledge of its molecular pathogenesis has shown that GC is not a single entity, but a constellation of different diseases, each with its own molecular and clinical characteristics. Currently, surgery represents the only curative approach for localized GC, but only 20% of patients (pts) showed resectable disease at diagnosis and, even in case of curative resection, the prognosis remains poor due to the high rate of disease relapse. In this context, multimodal perioperative approaches were developed in western and eastern countries in order to decrease relapse rates and improve survival. However, there is little consensus about the optimal treatment for non-metastatic GC. In this review, we summarize the current status and future developments of perioperative chemotherapy in resectable GC, attempting to find clear answers to the real problems in clinical practice.https://www.mdpi.com/2072-6694/11/3/399gastric cancerperioperative treatmentneoadjuvant chemotherapy |
| spellingShingle | Angelica Petrillo Luca Pompella Giuseppe Tirino Annalisa Pappalardo Maria Maddalena Laterza Marianna Caterino Michele Orditura Fortunato Ciardiello Eva Lieto Gennaro Galizia Carlo Castoro Ferdinando De Vita Perioperative Treatment in Resectable Gastric Cancer: Current Perspectives and Future Directions Cancers gastric cancer perioperative treatment neoadjuvant chemotherapy |
| title | Perioperative Treatment in Resectable Gastric Cancer: Current Perspectives and Future Directions |
| title_full | Perioperative Treatment in Resectable Gastric Cancer: Current Perspectives and Future Directions |
| title_fullStr | Perioperative Treatment in Resectable Gastric Cancer: Current Perspectives and Future Directions |
| title_full_unstemmed | Perioperative Treatment in Resectable Gastric Cancer: Current Perspectives and Future Directions |
| title_short | Perioperative Treatment in Resectable Gastric Cancer: Current Perspectives and Future Directions |
| title_sort | perioperative treatment in resectable gastric cancer current perspectives and future directions |
| topic | gastric cancer perioperative treatment neoadjuvant chemotherapy |
| url | https://www.mdpi.com/2072-6694/11/3/399 |
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