Outcome of transarterial radioembolization in patients with hepatocellular carcinoma as a first-line interventional therapy and after a previous transarterial chemoembolization
PurposeDue to a lack of data, there is an ongoing debate regarding the optimal frontline interventional therapy for unresectable hepatocellular carcinoma (HCC). The aim of the study is to compare the results of transarterial radioembolization (TARE) as the first-line therapy and as a subsequent ther...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Radiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fradi.2024.1346550/full |
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| author | Julia Wagenpfeil Julia Wagenpfeil Patrick Arthur Kupczyk Patrick Arthur Kupczyk Philipp Bruners Philipp Bruners Robert Siepmann Robert Siepmann Emelie Guendel Emelie Guendel Julian Alexander Luetkens Julian Alexander Luetkens Alexander Isaak Alexander Isaak Carsten Meyer Carsten Meyer Fabian Kuetting Claus Christian Pieper Claus Christian Pieper Ulrike Irmgard Attenberger Ulrike Irmgard Attenberger Daniel Kuetting Daniel Kuetting |
| author_facet | Julia Wagenpfeil Julia Wagenpfeil Patrick Arthur Kupczyk Patrick Arthur Kupczyk Philipp Bruners Philipp Bruners Robert Siepmann Robert Siepmann Emelie Guendel Emelie Guendel Julian Alexander Luetkens Julian Alexander Luetkens Alexander Isaak Alexander Isaak Carsten Meyer Carsten Meyer Fabian Kuetting Claus Christian Pieper Claus Christian Pieper Ulrike Irmgard Attenberger Ulrike Irmgard Attenberger Daniel Kuetting Daniel Kuetting |
| author_sort | Julia Wagenpfeil |
| collection | DOAJ |
| description | PurposeDue to a lack of data, there is an ongoing debate regarding the optimal frontline interventional therapy for unresectable hepatocellular carcinoma (HCC). The aim of the study is to compare the results of transarterial radioembolization (TARE) as the first-line therapy and as a subsequent therapy following prior transarterial chemoembolization (TACE) in these patients.MethodsA total of 83 patients were evaluated, with 38 patients having undergone at least one TACE session prior to TARE [27 male; mean age 67.2 years; 68.4% stage Barcelona clinic liver cancer (BCLC) B, 31.6% BCLC C]; 45 patients underwent primary TARE (33 male; mean age 69.9 years; 40% BCLC B, 58% BCLC C). Clinical [age, gender, BCLC stage, activity in gigabecquerel (GBq), Child–Pugh status, portal vein thrombosis, tumor volume] and procedural [overall survival (OS), local tumor control (LTC), and progression-free survival (PFS)] data were compared. A regression analysis was performed to evaluate OS, LTC, and PFS.ResultsNo differences were found in OS (95% CI: 1.12, P = 0.289), LTC (95% CI: 0.003, P = 0.95), and PFS (95% CI: 0.4, P = 0.525). The regression analysis revealed a relationship between Child–Pugh score (P = 0.005), size of HCC lesions (>10 cm) (P = 0.022), and OS; neither prior TACE (Child–Pugh B patients; 95% CI: 0.120, P = 0.729) nor number of lesions (>10; 95% CI: 2.930, P = 0.087) correlated with OS.ConclusionPrior TACE does not affect the outcome of TARE in unresectable HCC. |
| first_indexed | 2024-03-07T23:37:13Z |
| format | Article |
| id | doaj.art-2a4cc9fc5c3e4470bf0bc7603aa1ec58 |
| institution | Directory Open Access Journal |
| issn | 2673-8740 |
| language | English |
| last_indexed | 2024-03-07T23:37:13Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Radiology |
| spelling | doaj.art-2a4cc9fc5c3e4470bf0bc7603aa1ec582024-02-20T04:57:25ZengFrontiers Media S.A.Frontiers in Radiology2673-87402024-02-01410.3389/fradi.2024.13465501346550Outcome of transarterial radioembolization in patients with hepatocellular carcinoma as a first-line interventional therapy and after a previous transarterial chemoembolizationJulia Wagenpfeil0Julia Wagenpfeil1Patrick Arthur Kupczyk2Patrick Arthur Kupczyk3Philipp Bruners4Philipp Bruners5Robert Siepmann6Robert Siepmann7Emelie Guendel8Emelie Guendel9Julian Alexander Luetkens10Julian Alexander Luetkens11Alexander Isaak12Alexander Isaak13Carsten Meyer14Carsten Meyer15Fabian Kuetting16Claus Christian Pieper17Claus Christian Pieper18Ulrike Irmgard Attenberger19Ulrike Irmgard Attenberger20Daniel Kuetting21Daniel Kuetting22Department of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, GermanyCenter for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, GermanyCenter for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, GermanyCenter for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital of Aachen, Aachen, GermanyCenter for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital of Aachen, Aachen, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, GermanyCenter for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, GermanyCenter for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, GermanyCenter for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, GermanyCenter for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, GermanyCenter for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, GermanyCenter for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, GermanyCenter for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, GermanyCenter for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, GermanyPurposeDue to a lack of data, there is an ongoing debate regarding the optimal frontline interventional therapy for unresectable hepatocellular carcinoma (HCC). The aim of the study is to compare the results of transarterial radioembolization (TARE) as the first-line therapy and as a subsequent therapy following prior transarterial chemoembolization (TACE) in these patients.MethodsA total of 83 patients were evaluated, with 38 patients having undergone at least one TACE session prior to TARE [27 male; mean age 67.2 years; 68.4% stage Barcelona clinic liver cancer (BCLC) B, 31.6% BCLC C]; 45 patients underwent primary TARE (33 male; mean age 69.9 years; 40% BCLC B, 58% BCLC C). Clinical [age, gender, BCLC stage, activity in gigabecquerel (GBq), Child–Pugh status, portal vein thrombosis, tumor volume] and procedural [overall survival (OS), local tumor control (LTC), and progression-free survival (PFS)] data were compared. A regression analysis was performed to evaluate OS, LTC, and PFS.ResultsNo differences were found in OS (95% CI: 1.12, P = 0.289), LTC (95% CI: 0.003, P = 0.95), and PFS (95% CI: 0.4, P = 0.525). The regression analysis revealed a relationship between Child–Pugh score (P = 0.005), size of HCC lesions (>10 cm) (P = 0.022), and OS; neither prior TACE (Child–Pugh B patients; 95% CI: 0.120, P = 0.729) nor number of lesions (>10; 95% CI: 2.930, P = 0.087) correlated with OS.ConclusionPrior TACE does not affect the outcome of TARE in unresectable HCC.https://www.frontiersin.org/articles/10.3389/fradi.2024.1346550/fullhepatocellular carcinomatransarterial radioembolizationtransarterial chemoembolizationinterventional therapyBarcelona clinic liver cancer staging system |
| spellingShingle | Julia Wagenpfeil Julia Wagenpfeil Patrick Arthur Kupczyk Patrick Arthur Kupczyk Philipp Bruners Philipp Bruners Robert Siepmann Robert Siepmann Emelie Guendel Emelie Guendel Julian Alexander Luetkens Julian Alexander Luetkens Alexander Isaak Alexander Isaak Carsten Meyer Carsten Meyer Fabian Kuetting Claus Christian Pieper Claus Christian Pieper Ulrike Irmgard Attenberger Ulrike Irmgard Attenberger Daniel Kuetting Daniel Kuetting Outcome of transarterial radioembolization in patients with hepatocellular carcinoma as a first-line interventional therapy and after a previous transarterial chemoembolization Frontiers in Radiology hepatocellular carcinoma transarterial radioembolization transarterial chemoembolization interventional therapy Barcelona clinic liver cancer staging system |
| title | Outcome of transarterial radioembolization in patients with hepatocellular carcinoma as a first-line interventional therapy and after a previous transarterial chemoembolization |
| title_full | Outcome of transarterial radioembolization in patients with hepatocellular carcinoma as a first-line interventional therapy and after a previous transarterial chemoembolization |
| title_fullStr | Outcome of transarterial radioembolization in patients with hepatocellular carcinoma as a first-line interventional therapy and after a previous transarterial chemoembolization |
| title_full_unstemmed | Outcome of transarterial radioembolization in patients with hepatocellular carcinoma as a first-line interventional therapy and after a previous transarterial chemoembolization |
| title_short | Outcome of transarterial radioembolization in patients with hepatocellular carcinoma as a first-line interventional therapy and after a previous transarterial chemoembolization |
| title_sort | outcome of transarterial radioembolization in patients with hepatocellular carcinoma as a first line interventional therapy and after a previous transarterial chemoembolization |
| topic | hepatocellular carcinoma transarterial radioembolization transarterial chemoembolization interventional therapy Barcelona clinic liver cancer staging system |
| url | https://www.frontiersin.org/articles/10.3389/fradi.2024.1346550/full |
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