Dysphagia for medication in Parkinson’s disease
Abstract Dysphagia is common in Parkinson’s disease (PD) and is assumed to complicate medication intake. This study comprehensively investigates dysphagia for medication and its association with motor complications in PD. Based on a retrospective analysis, a two-dimensional and graduated classificat...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-022-00421-9 |
| _version_ | 1797641802847617024 |
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| author | Bendix Labeit Elijahu Berkovich Inga Claus Malte Roderigo Anna-Lena Schwake Dvora Izgelov Dorit Mimrod Sigrid Ahring Stephan Oelenberg Paul Muhle Verena Zentsch Fiona Wenninger Sonja Suntrup-Krueger Rainer Dziewas Tobias Warnecke |
| author_facet | Bendix Labeit Elijahu Berkovich Inga Claus Malte Roderigo Anna-Lena Schwake Dvora Izgelov Dorit Mimrod Sigrid Ahring Stephan Oelenberg Paul Muhle Verena Zentsch Fiona Wenninger Sonja Suntrup-Krueger Rainer Dziewas Tobias Warnecke |
| author_sort | Bendix Labeit |
| collection | DOAJ |
| description | Abstract Dysphagia is common in Parkinson’s disease (PD) and is assumed to complicate medication intake. This study comprehensively investigates dysphagia for medication and its association with motor complications in PD. Based on a retrospective analysis, a two-dimensional and graduated classification of dysphagia for medication was introduced differentiating swallowing efficiency and swallowing safety. In a subsequent prospective study, sixty-six PD patients underwent flexible endoscopic evaluation of swallowing, which included the swallowing of 2 tablets and capsules of different sizes. Dysphagia for medication was present in nearly 70% of PD patients and predicted motor complications according to the MDS-UPDRS-part-IV in a linear regression model. Capsules tended to be swallowed more efficiently compared to tablets, irrespective of size. A score of ≥1 on the swallow-related-MDS-UPDRS-items can be considered an optimal cut-off to predict dysphagia for medication. Swallowing impairment for oral medication may predispose to motor complications. |
| first_indexed | 2024-03-11T13:50:58Z |
| format | Article |
| id | doaj.art-2a4daef685964af188120033d84f9e05 |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-11T13:50:58Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-2a4daef685964af188120033d84f9e052023-11-02T08:41:30ZengNature Portfolionpj Parkinson's Disease2373-80572022-11-01811810.1038/s41531-022-00421-9Dysphagia for medication in Parkinson’s diseaseBendix Labeit0Elijahu Berkovich1Inga Claus2Malte Roderigo3Anna-Lena Schwake4Dvora Izgelov5Dorit Mimrod6Sigrid Ahring7Stephan Oelenberg8Paul Muhle9Verena Zentsch10Fiona Wenninger11Sonja Suntrup-Krueger12Rainer Dziewas13Tobias Warnecke14Department of Neurology with Institute of Translational Neurology, University Hospital MuensterClexio Biosciences LTDDepartment of Neurology with Institute of Translational Neurology, University Hospital MuensterDepartment of Neurology with Institute of Translational Neurology, University Hospital MuensterDepartment of Neurology with Institute of Translational Neurology, University Hospital MuensterClexio Biosciences LTDClexio Biosciences LTDDepartment of Neurology with Institute of Translational Neurology, University Hospital MuensterDepartment of Neurology with Institute of Translational Neurology, University Hospital MuensterDepartment of Neurology with Institute of Translational Neurology, University Hospital MuensterDepartment of Neurology with Institute of Translational Neurology, University Hospital MuensterDepartment of Neurology with Institute of Translational Neurology, University Hospital MuensterDepartment of Neurology with Institute of Translational Neurology, University Hospital MuensterDepartment of Neurology and Neurorehabilitation, Klinikum Osnabrueck – Academic teaching hospital of the WWU MuensterDepartment of Neurology and Neurorehabilitation, Klinikum Osnabrueck – Academic teaching hospital of the WWU MuensterAbstract Dysphagia is common in Parkinson’s disease (PD) and is assumed to complicate medication intake. This study comprehensively investigates dysphagia for medication and its association with motor complications in PD. Based on a retrospective analysis, a two-dimensional and graduated classification of dysphagia for medication was introduced differentiating swallowing efficiency and swallowing safety. In a subsequent prospective study, sixty-six PD patients underwent flexible endoscopic evaluation of swallowing, which included the swallowing of 2 tablets and capsules of different sizes. Dysphagia for medication was present in nearly 70% of PD patients and predicted motor complications according to the MDS-UPDRS-part-IV in a linear regression model. Capsules tended to be swallowed more efficiently compared to tablets, irrespective of size. A score of ≥1 on the swallow-related-MDS-UPDRS-items can be considered an optimal cut-off to predict dysphagia for medication. Swallowing impairment for oral medication may predispose to motor complications.https://doi.org/10.1038/s41531-022-00421-9 |
| spellingShingle | Bendix Labeit Elijahu Berkovich Inga Claus Malte Roderigo Anna-Lena Schwake Dvora Izgelov Dorit Mimrod Sigrid Ahring Stephan Oelenberg Paul Muhle Verena Zentsch Fiona Wenninger Sonja Suntrup-Krueger Rainer Dziewas Tobias Warnecke Dysphagia for medication in Parkinson’s disease npj Parkinson's Disease |
| title | Dysphagia for medication in Parkinson’s disease |
| title_full | Dysphagia for medication in Parkinson’s disease |
| title_fullStr | Dysphagia for medication in Parkinson’s disease |
| title_full_unstemmed | Dysphagia for medication in Parkinson’s disease |
| title_short | Dysphagia for medication in Parkinson’s disease |
| title_sort | dysphagia for medication in parkinson s disease |
| url | https://doi.org/10.1038/s41531-022-00421-9 |
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