Evolution of the calcium feedback steps of vertebrate phototransduction
We examined the genes encoding the proteins that mediate the Ca-feedback regulatory system in vertebrate rod and cone phototransduction. These proteins comprise four families: recoverin/visinin, the guanylyl cyclase activating proteins (GCAPs), the guanylyl cyclases (GCs) and the sodium/calcium-pota...
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| Format: | Article |
| Language: | English |
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The Royal Society
2018-09-01
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| Series: | Open Biology |
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| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180119 |
| _version_ | 1811327049708601344 |
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| author | Trevor D. Lamb David M. Hunt |
| author_facet | Trevor D. Lamb David M. Hunt |
| author_sort | Trevor D. Lamb |
| collection | DOAJ |
| description | We examined the genes encoding the proteins that mediate the Ca-feedback regulatory system in vertebrate rod and cone phototransduction. These proteins comprise four families: recoverin/visinin, the guanylyl cyclase activating proteins (GCAPs), the guanylyl cyclases (GCs) and the sodium/calcium-potassium exchangers (NCKXs). We identified a paralogon containing at least 36 phototransduction genes from at least fourteen families, including all four of the families involved in the Ca-feedback loop (recoverin/visinin, GCAPs, GCs and NCKXs). By combining analyses of gene synteny with analyses of the molecular phylogeny for each of these four families of genes for Ca-feedback regulation, we have established the likely pattern of gene duplications and losses underlying the expansion of isoforms, both before and during the two rounds of whole-genome duplication (2R WGD) that occurred in early vertebrate evolution. Furthermore, by combining our results with earlier evidence on the timing of duplication of the visual G-protein receptor kinase genes, we propose that specialization of proto-vertebrate photoreceptor cells for operation at high and low light intensities preceded the emergence of rhodopsin, which occurred during 2R WGD. |
| first_indexed | 2024-04-13T14:59:48Z |
| format | Article |
| id | doaj.art-2a4dd8cf8a33404a9f8a6e32f4d2181a |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-04-13T14:59:48Z |
| publishDate | 2018-09-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-2a4dd8cf8a33404a9f8a6e32f4d2181a2022-12-22T02:42:19ZengThe Royal SocietyOpen Biology2046-24412018-09-018910.1098/rsob.180119180119Evolution of the calcium feedback steps of vertebrate phototransductionTrevor D. LambDavid M. HuntWe examined the genes encoding the proteins that mediate the Ca-feedback regulatory system in vertebrate rod and cone phototransduction. These proteins comprise four families: recoverin/visinin, the guanylyl cyclase activating proteins (GCAPs), the guanylyl cyclases (GCs) and the sodium/calcium-potassium exchangers (NCKXs). We identified a paralogon containing at least 36 phototransduction genes from at least fourteen families, including all four of the families involved in the Ca-feedback loop (recoverin/visinin, GCAPs, GCs and NCKXs). By combining analyses of gene synteny with analyses of the molecular phylogeny for each of these four families of genes for Ca-feedback regulation, we have established the likely pattern of gene duplications and losses underlying the expansion of isoforms, both before and during the two rounds of whole-genome duplication (2R WGD) that occurred in early vertebrate evolution. Furthermore, by combining our results with earlier evidence on the timing of duplication of the visual G-protein receptor kinase genes, we propose that specialization of proto-vertebrate photoreceptor cells for operation at high and low light intensities preceded the emergence of rhodopsin, which occurred during 2R WGD.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180119evolutionphototransductionrecoveringuanylyl cyclase activating proteinguanylyl cyclasesodium/calcium–potassium exchanger |
| spellingShingle | Trevor D. Lamb David M. Hunt Evolution of the calcium feedback steps of vertebrate phototransduction Open Biology evolution phototransduction recoverin guanylyl cyclase activating protein guanylyl cyclase sodium/calcium–potassium exchanger |
| title | Evolution of the calcium feedback steps of vertebrate phototransduction |
| title_full | Evolution of the calcium feedback steps of vertebrate phototransduction |
| title_fullStr | Evolution of the calcium feedback steps of vertebrate phototransduction |
| title_full_unstemmed | Evolution of the calcium feedback steps of vertebrate phototransduction |
| title_short | Evolution of the calcium feedback steps of vertebrate phototransduction |
| title_sort | evolution of the calcium feedback steps of vertebrate phototransduction |
| topic | evolution phototransduction recoverin guanylyl cyclase activating protein guanylyl cyclase sodium/calcium–potassium exchanger |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180119 |
| work_keys_str_mv | AT trevordlamb evolutionofthecalciumfeedbackstepsofvertebratephototransduction AT davidmhunt evolutionofthecalciumfeedbackstepsofvertebratephototransduction |