Chronic consumption of avocado seed (Persea americana) promotes a negative energy balance and body weight reduction in high-fat diet exposed mice: Implications for functional foods
Obesity is the main challenge for public health systems. Functional foods have emerged as an alternative to the ineffectiveness of pharmacological therapies. However, it is necessary to investigate to find sources of raw material for its preparation. The aim of this work was to evaluate the function...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623003511 |
| _version_ | 1797688949653635072 |
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| author | Fátima G. Velázquez-González Mercedes V. Urquiza-Martínez Raul Manhães-de-Castro Pedro A. Romero-Juárez Zaira I. Bedolla-Valdez Juan M. Ponce-Pérez Estefanía Farías-Gaytán María S. Vázquez-Garcidueñas Gerardo Vázquez-Marrufo Ana E. Toscano Luz Torner José Pérez-Villarreal Omar Guzmán-Quevedo |
| author_facet | Fátima G. Velázquez-González Mercedes V. Urquiza-Martínez Raul Manhães-de-Castro Pedro A. Romero-Juárez Zaira I. Bedolla-Valdez Juan M. Ponce-Pérez Estefanía Farías-Gaytán María S. Vázquez-Garcidueñas Gerardo Vázquez-Marrufo Ana E. Toscano Luz Torner José Pérez-Villarreal Omar Guzmán-Quevedo |
| author_sort | Fátima G. Velázquez-González |
| collection | DOAJ |
| description | Obesity is the main challenge for public health systems. Functional foods have emerged as an alternative to the ineffectiveness of pharmacological therapies. However, it is necessary to investigate to find sources of raw material for its preparation. The aim of this work was to evaluate the functional effects of residual avocado seed in diet-induced obese mice. Animals were fed a high-fat diet supplemented with avocado seed (1.25%) for 6 weeks. Body weight, food intake, satiety, physical activity, and energy expenditure-involved gene expression were measured. Supplementation with avocado seed led to reduced body weight, delayed satiety, increased physical activity, and induced Dio2 and Adrb1 expression in hypothalamus and white adipose tissue, respectively. No changes in markers of hepatic injury were observed. In conclusion, avocado seed exerts functional effects on obese mice, by promoting energy expenditure, without toxicity effects, making it possible to use this by-product in the development of functional foods. |
| first_indexed | 2024-03-12T01:37:56Z |
| format | Article |
| id | doaj.art-2a4f86df19ca4c2e828b2d48aadaa818 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-12T01:37:56Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-2a4f86df19ca4c2e828b2d48aadaa8182023-09-11T04:16:54ZengElsevierJournal of Functional Foods1756-46462023-09-01108105751Chronic consumption of avocado seed (Persea americana) promotes a negative energy balance and body weight reduction in high-fat diet exposed mice: Implications for functional foodsFátima G. Velázquez-González0Mercedes V. Urquiza-Martínez1Raul Manhães-de-Castro2Pedro A. Romero-Juárez3Zaira I. Bedolla-Valdez4Juan M. Ponce-Pérez5Estefanía Farías-Gaytán6María S. Vázquez-Garcidueñas7Gerardo Vázquez-Marrufo8Ana E. Toscano9Luz Torner10José Pérez-Villarreal11Omar Guzmán-Quevedo12Laboratory of Experimental Neuronutrition and Food Engineering, Tecnológico Nacional de México (TECNM) / Instituto Tecnológico Superior de Tacámbaro, Tacámbaro 61651, Michoacán, Mexico; Tecnológico Nacional de México (TECNM) / Instituto Tecnológico Superior de Uruapan, Uruapan 60015, Michoacán, MexicoLaboratory of Experimental Neuronutrition and Food Engineering, Tecnológico Nacional de México (TECNM) / Instituto Tecnológico Superior de Tacámbaro, Tacámbaro 61651, Michoacán, Mexico; Current affiliation Universidad Intercultural Indígena de Michoacán, Pátzcuaro 61614, Michoacán, MexicoStudies in Nutrition and Phenotypic Plasticity Unit, Department of Nutrition, Federal University of Pernambuco, Recife 50670-901, PE, Brazil; Department of Nutrition, Federal University of Pernambuco, Recife 50670-901, PE, BrazilLaboratory of Experimental Neuronutrition and Food Engineering, Tecnológico Nacional de México (TECNM) / Instituto Tecnológico Superior de Tacámbaro, Tacámbaro 61651, Michoacán, Mexico; Maestría en Ciencias de la Salud, Facultad de Medicina, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58020, Michoacán, Mexico; Centro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Morelia 58330, Michoacán, MexicoTecnológico Nacional de México (TECNM) / Instituto Tecnológico Superior de Uruapan, Uruapan 60015, Michoacán, MexicoLaboratory of Experimental Neuronutrition and Food Engineering, Tecnológico Nacional de México (TECNM) / Instituto Tecnológico Superior de Tacámbaro, Tacámbaro 61651, Michoacán, MexicoLaboratory of Experimental Neuronutrition and Food Engineering, Tecnológico Nacional de México (TECNM) / Instituto Tecnológico Superior de Tacámbaro, Tacámbaro 61651, Michoacán, Mexico; Centro Multidisciplinario de Estudios en Biotecnología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58893, Michoacán, Mexico; División de Estudios de Posgrado, Facultad de Medicina, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58020, Michoacán, Mexico; Programa Institucional de Doctorado en Ciencias Biológicas (opción en Biotecnología Molecular), Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Michoacán, MexicoDivisión de Estudios de Posgrado, Facultad de Medicina, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58020, Michoacán, MexicoCentro Multidisciplinario de Estudios en Biotecnología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58893, Michoacán, MexicoStudies in Nutrition and Phenotypic Plasticity Unit, Department of Nutrition, Federal University of Pernambuco, Recife 50670-901, PE, Brazil; Department of Nursing, CAV, Federal University of Pernambuco, Recife 55608-680, PE, Brazil; Postgraduate Program in Neuropsychiatry and Behavioral Sciences, Federal University of Pernambuco, Recife 50740-600, PE, BrazilCentro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Morelia 58330, Michoacán, MexicoTecnológico Nacional de México (TECNM) / Instituto Tecnológico Superior de Uruapan, Uruapan 60015, Michoacán, MexicoLaboratory of Experimental Neuronutrition and Food Engineering, Tecnológico Nacional de México (TECNM) / Instituto Tecnológico Superior de Tacámbaro, Tacámbaro 61651, Michoacán, Mexico; Centro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Morelia 58330, Michoacán, Mexico; Postgraduate Program in Neuropsychiatry and Behavioral Sciences, Federal University of Pernambuco, Recife 50740-600, PE, Brazil; Corresponding author at: Laboratory of Experimental Neuronutrition and Food Engineering, Tecnológico Nacional de México (TECNM) / Instituto Tecnológico Superior de Tacámbaro, Tacámbaro 61651, Michoacán, Mexico.Obesity is the main challenge for public health systems. Functional foods have emerged as an alternative to the ineffectiveness of pharmacological therapies. However, it is necessary to investigate to find sources of raw material for its preparation. The aim of this work was to evaluate the functional effects of residual avocado seed in diet-induced obese mice. Animals were fed a high-fat diet supplemented with avocado seed (1.25%) for 6 weeks. Body weight, food intake, satiety, physical activity, and energy expenditure-involved gene expression were measured. Supplementation with avocado seed led to reduced body weight, delayed satiety, increased physical activity, and induced Dio2 and Adrb1 expression in hypothalamus and white adipose tissue, respectively. No changes in markers of hepatic injury were observed. In conclusion, avocado seed exerts functional effects on obese mice, by promoting energy expenditure, without toxicity effects, making it possible to use this by-product in the development of functional foods.http://www.sciencedirect.com/science/article/pii/S1756464623003511ObesityHypothalamusEnergy balanceEnergy expenditureAvocado seedFunctional food |
| spellingShingle | Fátima G. Velázquez-González Mercedes V. Urquiza-Martínez Raul Manhães-de-Castro Pedro A. Romero-Juárez Zaira I. Bedolla-Valdez Juan M. Ponce-Pérez Estefanía Farías-Gaytán María S. Vázquez-Garcidueñas Gerardo Vázquez-Marrufo Ana E. Toscano Luz Torner José Pérez-Villarreal Omar Guzmán-Quevedo Chronic consumption of avocado seed (Persea americana) promotes a negative energy balance and body weight reduction in high-fat diet exposed mice: Implications for functional foods Journal of Functional Foods Obesity Hypothalamus Energy balance Energy expenditure Avocado seed Functional food |
| title | Chronic consumption of avocado seed (Persea americana) promotes a negative energy balance and body weight reduction in high-fat diet exposed mice: Implications for functional foods |
| title_full | Chronic consumption of avocado seed (Persea americana) promotes a negative energy balance and body weight reduction in high-fat diet exposed mice: Implications for functional foods |
| title_fullStr | Chronic consumption of avocado seed (Persea americana) promotes a negative energy balance and body weight reduction in high-fat diet exposed mice: Implications for functional foods |
| title_full_unstemmed | Chronic consumption of avocado seed (Persea americana) promotes a negative energy balance and body weight reduction in high-fat diet exposed mice: Implications for functional foods |
| title_short | Chronic consumption of avocado seed (Persea americana) promotes a negative energy balance and body weight reduction in high-fat diet exposed mice: Implications for functional foods |
| title_sort | chronic consumption of avocado seed persea americana promotes a negative energy balance and body weight reduction in high fat diet exposed mice implications for functional foods |
| topic | Obesity Hypothalamus Energy balance Energy expenditure Avocado seed Functional food |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623003511 |
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