AN1284 attenuates steatosis, lipogenesis, and fibrosis in mice with pre-existing non-alcoholic steatohepatitis and directly affects aryl hydrocarbon receptor in a hepatic cell line

AN1284 attenuates steatosis, lipogenesis, and fibrosis in mice with pre-existing non-alcoholic steatohepatitis and directly affects aryl hydrocarbon receptor in a hepatic cell line

Non-alcoholic steatohepatitis (NASH) is an aggressive form of fatty liver disease with hepatic inflammation and fibrosis for which there is currently no drug treatment. This study determined whether an indoline derivative, AN1284, which significantly reduced damage in a model of acute liver disease,...

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Bibliographic Details
Main Authors: Adi S. Yehezkel, Nathalie Abudi, Yuval Nevo, Hadar Benyamini, Sharona Elgavish, Marta Weinstock, Rinat Abramovitch
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Endocrinology
Subjects:
aryl hydrocarbon receptor
nuclear receptors
oxidative stress
retinoid X receptor
RNA-sequencing analysis
fatty acid synthase
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1226808/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1226808/full

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