ß-endorphins as Possible Markers for Therapeutic Drug Monitoring
This study was performed in order to investigate possible role of brain beta-endorphins as markers of antidepressive drugs therapy monitoring. Experiment was done using amitriptyline and trazodone as antidepressants. For quantification of brain beta-endorphins we used RIA technique. Our results sho...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2007-02-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3081 |
| _version_ | 1797260731947679744 |
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| author | Radivoj Jadrić Emina Kiseljaković Sabaheta Hasić Mira Winterhalter-Jadrić |
| author_facet | Radivoj Jadrić Emina Kiseljaković Sabaheta Hasić Mira Winterhalter-Jadrić |
| author_sort | Radivoj Jadrić |
| collection | DOAJ |
| description |
This study was performed in order to investigate possible role of brain beta-endorphins as markers of antidepressive drugs therapy monitoring. Experiment was done using amitriptyline and trazodone as antidepressants. For quantification of brain beta-endorphins we used RIA technique. Our results showed significant decrease of brain beta-endorphins concentration in drug-pretreated animals, vs. those in of control group treated with 0,95% NaCl. The lower values were obtained in trazodone pre-treated animals. This study shows that use of psychoactive drugs have influence on brain beta-endorphins concentration. beta-endorphins could be of great importance, used as markers for evaluation of patient treatment.
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| first_indexed | 2024-04-24T23:29:59Z |
| format | Article |
| id | doaj.art-2a500e65908c4291a6bd693016a0622a |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:29:59Z |
| publishDate | 2007-02-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-2a500e65908c4291a6bd693016a0622a2024-03-15T14:42:39ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2007-02-017110.17305/bjbms.2007.3081652ß-endorphins as Possible Markers for Therapeutic Drug MonitoringRadivoj Jadrić0Emina Kiseljaković1Sabaheta Hasić2Mira Winterhalter-Jadrić3Institute for Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute for Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute for Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo This study was performed in order to investigate possible role of brain beta-endorphins as markers of antidepressive drugs therapy monitoring. Experiment was done using amitriptyline and trazodone as antidepressants. For quantification of brain beta-endorphins we used RIA technique. Our results showed significant decrease of brain beta-endorphins concentration in drug-pretreated animals, vs. those in of control group treated with 0,95% NaCl. The lower values were obtained in trazodone pre-treated animals. This study shows that use of psychoactive drugs have influence on brain beta-endorphins concentration. beta-endorphins could be of great importance, used as markers for evaluation of patient treatment. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3081amitriptylinetrazodoneβ-endorphinsratbrain |
| spellingShingle | Radivoj Jadrić Emina Kiseljaković Sabaheta Hasić Mira Winterhalter-Jadrić ß-endorphins as Possible Markers for Therapeutic Drug Monitoring Biomolecules & Biomedicine amitriptyline trazodone β-endorphins rat brain |
| title | ß-endorphins as Possible Markers for Therapeutic Drug Monitoring |
| title_full | ß-endorphins as Possible Markers for Therapeutic Drug Monitoring |
| title_fullStr | ß-endorphins as Possible Markers for Therapeutic Drug Monitoring |
| title_full_unstemmed | ß-endorphins as Possible Markers for Therapeutic Drug Monitoring |
| title_short | ß-endorphins as Possible Markers for Therapeutic Drug Monitoring |
| title_sort | ss endorphins as possible markers for therapeutic drug monitoring |
| topic | amitriptyline trazodone β-endorphins rat brain |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3081 |
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