Factors associated with contralateral liver hypertrophy after unilateral radioembolization for hepatocellular carcinoma.
Radioembolization for the treatment of hepatocellular carcinoma (HCC) induces liver volume changes referred to as "atrophy-hypertrophy complex". The aim of this study was to investigate lobar liver volume changes after unilateral radioembolization and to search for factors associated with...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5510860?pdf=render |
| _version_ | 1818971536205283328 |
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| author | Juliane Goebel Maximilian Sulke Andrea Lazik-Palm Thomas Goebel Alexander Dechêne Alexander Bellendorf Stefan Mueller Lale Umutlu Jens Theysohn |
| author_facet | Juliane Goebel Maximilian Sulke Andrea Lazik-Palm Thomas Goebel Alexander Dechêne Alexander Bellendorf Stefan Mueller Lale Umutlu Jens Theysohn |
| author_sort | Juliane Goebel |
| collection | DOAJ |
| description | Radioembolization for the treatment of hepatocellular carcinoma (HCC) induces liver volume changes referred to as "atrophy-hypertrophy complex". The aim of this study was to investigate lobar liver volume changes after unilateral radioembolization and to search for factors associated with hypertrophy of the untreated lobe.Seventy-five patients were retrospectively evaluated. Inclusion criteria were: (1) right-lobar radioembolization for unresectable unilateral HCC, (2) available liver computed tomography scans before, 1, 3, and at least 6 months after radioembolization. Baseline patient characteristics included clinical features, laboratory results, spleen volume, and liver computed tomography. Absolute and relative (referred to the whole liver volume) liver lobe volumes (LLV) as well as relative LLV (rLLV) change per month were evaluated and compared.Absolute and relative contralateral LLV continuously increased after radioembolization (p<0.001). Mean relative contralateral LLV increased from 36±11.6% before radioembolization to 50±15.3% 6 months after radioembolization. Median contralateral rLLV increase/month (within first 6 months) was 2.5%. Contralateral rLLV increase/month was significantly lower in patients with ascites (p = 0.017) or platelet count <100/nl (p = 0.009). An inverse correlation of contralateral rLVV increase/month with spleen volume (p = 0.017), patient age (p = 0.024), Child Pugh score (p = 0.001), and tumor burden (p = 0.001) was found.Significant contralateral hypertrophy and ipsilateral atrophy were common after unilateral radioembolization. Small spleen volume, low patient age, low Child Pugh score, absence of ascites, platelet count ≥100/nl, and low tumor burden were associated with increased contralateral hypertrophy, indicating that younger patients with compensated cirrhosis might benefit most from radioembolization in a "bridge-to-resection" setting. |
| first_indexed | 2024-12-20T14:53:56Z |
| format | Article |
| id | doaj.art-2a526e728d0546d2a67f7f6347771e9d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T14:53:56Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2a526e728d0546d2a67f7f6347771e9d2022-12-21T19:36:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01127e018148810.1371/journal.pone.0181488Factors associated with contralateral liver hypertrophy after unilateral radioembolization for hepatocellular carcinoma.Juliane GoebelMaximilian SulkeAndrea Lazik-PalmThomas GoebelAlexander DechêneAlexander BellendorfStefan MuellerLale UmutluJens TheysohnRadioembolization for the treatment of hepatocellular carcinoma (HCC) induces liver volume changes referred to as "atrophy-hypertrophy complex". The aim of this study was to investigate lobar liver volume changes after unilateral radioembolization and to search for factors associated with hypertrophy of the untreated lobe.Seventy-five patients were retrospectively evaluated. Inclusion criteria were: (1) right-lobar radioembolization for unresectable unilateral HCC, (2) available liver computed tomography scans before, 1, 3, and at least 6 months after radioembolization. Baseline patient characteristics included clinical features, laboratory results, spleen volume, and liver computed tomography. Absolute and relative (referred to the whole liver volume) liver lobe volumes (LLV) as well as relative LLV (rLLV) change per month were evaluated and compared.Absolute and relative contralateral LLV continuously increased after radioembolization (p<0.001). Mean relative contralateral LLV increased from 36±11.6% before radioembolization to 50±15.3% 6 months after radioembolization. Median contralateral rLLV increase/month (within first 6 months) was 2.5%. Contralateral rLLV increase/month was significantly lower in patients with ascites (p = 0.017) or platelet count <100/nl (p = 0.009). An inverse correlation of contralateral rLVV increase/month with spleen volume (p = 0.017), patient age (p = 0.024), Child Pugh score (p = 0.001), and tumor burden (p = 0.001) was found.Significant contralateral hypertrophy and ipsilateral atrophy were common after unilateral radioembolization. Small spleen volume, low patient age, low Child Pugh score, absence of ascites, platelet count ≥100/nl, and low tumor burden were associated with increased contralateral hypertrophy, indicating that younger patients with compensated cirrhosis might benefit most from radioembolization in a "bridge-to-resection" setting.http://europepmc.org/articles/PMC5510860?pdf=render |
| spellingShingle | Juliane Goebel Maximilian Sulke Andrea Lazik-Palm Thomas Goebel Alexander Dechêne Alexander Bellendorf Stefan Mueller Lale Umutlu Jens Theysohn Factors associated with contralateral liver hypertrophy after unilateral radioembolization for hepatocellular carcinoma. PLoS ONE |
| title | Factors associated with contralateral liver hypertrophy after unilateral radioembolization for hepatocellular carcinoma. |
| title_full | Factors associated with contralateral liver hypertrophy after unilateral radioembolization for hepatocellular carcinoma. |
| title_fullStr | Factors associated with contralateral liver hypertrophy after unilateral radioembolization for hepatocellular carcinoma. |
| title_full_unstemmed | Factors associated with contralateral liver hypertrophy after unilateral radioembolization for hepatocellular carcinoma. |
| title_short | Factors associated with contralateral liver hypertrophy after unilateral radioembolization for hepatocellular carcinoma. |
| title_sort | factors associated with contralateral liver hypertrophy after unilateral radioembolization for hepatocellular carcinoma |
| url | http://europepmc.org/articles/PMC5510860?pdf=render |
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