Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease

Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease

Alzheimer's disease (AD) is an increasingly pressing worldwide public-health, social, political and economic concern. Despite significant investment in multiple traditional therapeutic strategies that have achieved success in preclinical models addressing the pathological hallmarks of the disea...

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Bibliographic Details
Main Author: Isaac G Onyango
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
Alzheimer′s disease; mitochondria; bioenergetics; mitochondrial DNA; neuroinflammation; mitohormesis; caloric restriction; hypometabolism; mitophagy; mitochondrial biogenesis; recombinant-human mitochondrial transcription factor A; antioxidants; proteasome; mitochondrial transcription activator-like effector nucleases; clustered regularly interspaced short palindromic repeats/associated protein 9 (CRISPR/ Cas9); caloric restriction; stem cells
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=1;spage=19;epage=25;aulast=Onyango

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