Insulin resistance, C-reactive protein, diastolic to systolic blood pressure ratio and epicardial fat are related to sedentary time, and inversely related to physical activity in school-aged children
BackgroundPhysical activity (PA) is beneficial for the overall health. Objectives are: (1) To compare metabolic (MRM) and cardiovascular-risk-markers (CRM) in children according to their PA-level; (2) to explore the associations of MRM and CRM with PA and sedentary time (ST); and (3) to identify the...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1339860/full |
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| author | Fidanka Vasileva Fidanka Vasileva Gemma Carreras-Badosa Judit Bassols Juan Serrano-Ferrer Raquel Font-Lladó Raquel Font-Lladó Victor López-Ros Inés Osiniri Jose-Maria Martínez-Calcerrada Marta San Millán Marta San Millán Abel López-Bermejo Abel López-Bermejo Abel López-Bermejo Anna Prats-Puig Anna Prats-Puig |
| author_facet | Fidanka Vasileva Fidanka Vasileva Gemma Carreras-Badosa Judit Bassols Juan Serrano-Ferrer Raquel Font-Lladó Raquel Font-Lladó Victor López-Ros Inés Osiniri Jose-Maria Martínez-Calcerrada Marta San Millán Marta San Millán Abel López-Bermejo Abel López-Bermejo Abel López-Bermejo Anna Prats-Puig Anna Prats-Puig |
| author_sort | Fidanka Vasileva |
| collection | DOAJ |
| description | BackgroundPhysical activity (PA) is beneficial for the overall health. Objectives are: (1) To compare metabolic (MRM) and cardiovascular-risk-markers (CRM) in children according to their PA-level; (2) to explore the associations of MRM and CRM with PA and sedentary time (ST); and (3) to identify the associations between MRM and CRM in less (LA) and more active (MA) children.MethodsA total of 238 apparently healthy school-aged children were enrolled (132 boys/106 girls; 9.1 ± 1.8 years) and body mass index standard deviation score (BMI SDS) and blood pressure were assessed. Fasting venous blood sampling was performed to assess insulin resistance (HOMA-IR) and high-sensitivity-C-reactive protein (hsCRP). Epicardial fat, interventricular septal and left ventricular posterior wall thicknesses were assessed by high-resolution ultrasonography. PA and ST were assessed by enKid-questionnaire. Children were classified based on enKid-score as being LA and MA (below and above 50th percentile for PA).ResultsMA-children had lower values for: BMI SDS, diastolic-to-systolic blood pressure ratio, HOMA-IR and hsCRP (7.02 to 61.5% lower, p = 0.040 to p < 0.0001) compared to LA-children. MRM and CRM were positively associated with ST (p = 0.003 to p < 0.001), and negatively associated with PA (p = 0.044 to p < 0.001). Finally, MRM were positively associated with CRM (p = 0.008 to p < 0.0001). Interestingly, the latter associations were observed in LA-children but were not present in MA-children.ConclusionMore PA is associated with better cardio-metabolic profile in school-aged children. PA seems to modulate the associations between MRM and CRM, thus reinforcing the idea that fostering PA in children may lower the risk for development of a cardio-metabolic disease. |
| first_indexed | 2024-04-24T22:22:13Z |
| format | Article |
| id | doaj.art-2a534b5d84704780a10addb1da531848 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-24T22:22:13Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-2a534b5d84704780a10addb1da5318482024-03-20T05:14:37ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-03-011210.3389/fpubh.2024.13398601339860Insulin resistance, C-reactive protein, diastolic to systolic blood pressure ratio and epicardial fat are related to sedentary time, and inversely related to physical activity in school-aged childrenFidanka Vasileva0Fidanka Vasileva1Gemma Carreras-Badosa2Judit Bassols3Juan Serrano-Ferrer4Raquel Font-Lladó5Raquel Font-Lladó6Victor López-Ros7Inés Osiniri8Jose-Maria Martínez-Calcerrada9Marta San Millán10Marta San Millán11Abel López-Bermejo12Abel López-Bermejo13Abel López-Bermejo14Anna Prats-Puig15Anna Prats-Puig16Pediatric Endocrinology Research Group, Girona Institute for Biomedical Research, Girona, SpainUniversity School of Health and Sport, University of Girona, Girona, SpainPediatric Endocrinology Research Group, Girona Institute for Biomedical Research, Girona, SpainMaternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research, Girona, SpainUniversity School of Health and Sport, University of Girona, Girona, SpainUniversity School of Health and Sport, University of Girona, Girona, SpainResearch Group of Culture and Education, Institute of Educational Research, University of Girona, Girona, SpainChair of Sport and Physical Education – Centre of Olympic Studies, University of Girona, Girona, SpainPediatrics, Clinica Bofill, Girona, SpainInstitute of Legal Medicine of Catalonia, Girona, SpainUniversity School of Health and Sport, University of Girona, Girona, SpainResearch Group of Clinical Anatomy, Embryology and Neuroscience, Department of Medical Sciences, University of Girona, Girona, SpainPediatric Endocrinology Research Group, Girona Institute for Biomedical Research, Girona, SpainDepartment of Medical Sciences, University of Girona, Girona, Spain0Pediatric Endocrinology, Dr. Josep Trueta Hospital, Girona, SpainUniversity School of Health and Sport, University of Girona, Girona, SpainResearch Group of Clinical Anatomy, Embryology and Neuroscience, Department of Medical Sciences, University of Girona, Girona, SpainBackgroundPhysical activity (PA) is beneficial for the overall health. Objectives are: (1) To compare metabolic (MRM) and cardiovascular-risk-markers (CRM) in children according to their PA-level; (2) to explore the associations of MRM and CRM with PA and sedentary time (ST); and (3) to identify the associations between MRM and CRM in less (LA) and more active (MA) children.MethodsA total of 238 apparently healthy school-aged children were enrolled (132 boys/106 girls; 9.1 ± 1.8 years) and body mass index standard deviation score (BMI SDS) and blood pressure were assessed. Fasting venous blood sampling was performed to assess insulin resistance (HOMA-IR) and high-sensitivity-C-reactive protein (hsCRP). Epicardial fat, interventricular septal and left ventricular posterior wall thicknesses were assessed by high-resolution ultrasonography. PA and ST were assessed by enKid-questionnaire. Children were classified based on enKid-score as being LA and MA (below and above 50th percentile for PA).ResultsMA-children had lower values for: BMI SDS, diastolic-to-systolic blood pressure ratio, HOMA-IR and hsCRP (7.02 to 61.5% lower, p = 0.040 to p < 0.0001) compared to LA-children. MRM and CRM were positively associated with ST (p = 0.003 to p < 0.001), and negatively associated with PA (p = 0.044 to p < 0.001). Finally, MRM were positively associated with CRM (p = 0.008 to p < 0.0001). Interestingly, the latter associations were observed in LA-children but were not present in MA-children.ConclusionMore PA is associated with better cardio-metabolic profile in school-aged children. PA seems to modulate the associations between MRM and CRM, thus reinforcing the idea that fostering PA in children may lower the risk for development of a cardio-metabolic disease.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1339860/fullepicardial fatinterventricular septal thicknessleft ventricular posterior wall thicknessinsulin resistanceC-reactive proteinphysical activity |
| spellingShingle | Fidanka Vasileva Fidanka Vasileva Gemma Carreras-Badosa Judit Bassols Juan Serrano-Ferrer Raquel Font-Lladó Raquel Font-Lladó Victor López-Ros Inés Osiniri Jose-Maria Martínez-Calcerrada Marta San Millán Marta San Millán Abel López-Bermejo Abel López-Bermejo Abel López-Bermejo Anna Prats-Puig Anna Prats-Puig Insulin resistance, C-reactive protein, diastolic to systolic blood pressure ratio and epicardial fat are related to sedentary time, and inversely related to physical activity in school-aged children Frontiers in Public Health epicardial fat interventricular septal thickness left ventricular posterior wall thickness insulin resistance C-reactive protein physical activity |
| title | Insulin resistance, C-reactive protein, diastolic to systolic blood pressure ratio and epicardial fat are related to sedentary time, and inversely related to physical activity in school-aged children |
| title_full | Insulin resistance, C-reactive protein, diastolic to systolic blood pressure ratio and epicardial fat are related to sedentary time, and inversely related to physical activity in school-aged children |
| title_fullStr | Insulin resistance, C-reactive protein, diastolic to systolic blood pressure ratio and epicardial fat are related to sedentary time, and inversely related to physical activity in school-aged children |
| title_full_unstemmed | Insulin resistance, C-reactive protein, diastolic to systolic blood pressure ratio and epicardial fat are related to sedentary time, and inversely related to physical activity in school-aged children |
| title_short | Insulin resistance, C-reactive protein, diastolic to systolic blood pressure ratio and epicardial fat are related to sedentary time, and inversely related to physical activity in school-aged children |
| title_sort | insulin resistance c reactive protein diastolic to systolic blood pressure ratio and epicardial fat are related to sedentary time and inversely related to physical activity in school aged children |
| topic | epicardial fat interventricular septal thickness left ventricular posterior wall thickness insulin resistance C-reactive protein physical activity |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1339860/full |
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