Active processes make mixed lipid membranes either flat or crumpled
Whether live cell membranes show miscibility phase transitions (MPTs), and if so, how they fluctuate near the transitions remain outstanding unresolved issues in physics and biology alike. Motivated by these questions we construct a generic hydrodynamic theory for lipid membranes that are active, du...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2018-01-01
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| Series: | New Journal of Physics |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/1367-2630/aa9ed2 |
| _version_ | 1797750671523446784 |
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| author | Tirthankar Banerjee Abhik Basu |
| author_facet | Tirthankar Banerjee Abhik Basu |
| author_sort | Tirthankar Banerjee |
| collection | DOAJ |
| description | Whether live cell membranes show miscibility phase transitions (MPTs), and if so, how they fluctuate near the transitions remain outstanding unresolved issues in physics and biology alike. Motivated by these questions we construct a generic hydrodynamic theory for lipid membranes that are active, due for instance, to the molecular motors in the surrounding cytoskeleton, or active protein components in the membrane itself. We use this to uncover a direct correspondence between membrane fluctuations and MPTs. Several testable predictions are made: (i) generic active stiffening with orientational long range order (flat membrane) or softening with crumpling of the membrane, controlled by the active tension and (ii) for mixed lipid membranes, capturing the nature of putative MPTs by measuring the membrane conformation fluctuations. Possibilities of both first and second order MPTs in mixed active membranes are argued for. Near second order MPTs, active stiffening (softening) manifests as a super-stiff (super-soft) membrane . Our predictions are testable in a variety of in vitro systems, e.g. live cytoskeletal extracts deposited on liposomes and lipid membranes containing active proteins embedded in a passive fluid. |
| first_indexed | 2024-03-12T16:37:13Z |
| format | Article |
| id | doaj.art-2a53981d1039407fb05fad32c64083f2 |
| institution | Directory Open Access Journal |
| issn | 1367-2630 |
| language | English |
| last_indexed | 2024-03-12T16:37:13Z |
| publishDate | 2018-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | New Journal of Physics |
| spelling | doaj.art-2a53981d1039407fb05fad32c64083f22023-08-08T14:50:04ZengIOP PublishingNew Journal of Physics1367-26302018-01-0120101302810.1088/1367-2630/aa9ed2Active processes make mixed lipid membranes either flat or crumpledTirthankar Banerjee0Abhik Basu1Condensed Matter Physics Division, Saha Institute of Nuclear Physics , Calcutta 700064, IndiaCondensed Matter Physics Division, Saha Institute of Nuclear Physics , Calcutta 700064, India; Max-Planck Institut für Physik Komplexer Systeme , Nöthnitzer Str. 38, Dresden, D-01187 GermanyWhether live cell membranes show miscibility phase transitions (MPTs), and if so, how they fluctuate near the transitions remain outstanding unresolved issues in physics and biology alike. Motivated by these questions we construct a generic hydrodynamic theory for lipid membranes that are active, due for instance, to the molecular motors in the surrounding cytoskeleton, or active protein components in the membrane itself. We use this to uncover a direct correspondence between membrane fluctuations and MPTs. Several testable predictions are made: (i) generic active stiffening with orientational long range order (flat membrane) or softening with crumpling of the membrane, controlled by the active tension and (ii) for mixed lipid membranes, capturing the nature of putative MPTs by measuring the membrane conformation fluctuations. Possibilities of both first and second order MPTs in mixed active membranes are argued for. Near second order MPTs, active stiffening (softening) manifests as a super-stiff (super-soft) membrane . Our predictions are testable in a variety of in vitro systems, e.g. live cytoskeletal extracts deposited on liposomes and lipid membranes containing active proteins embedded in a passive fluid.https://doi.org/10.1088/1367-2630/aa9ed2mixed fluid membranenonequilibrium statistical mechanicsmiscibility phase transitionsmembrane fluctuationscontinuum hydrodynamic approaches |
| spellingShingle | Tirthankar Banerjee Abhik Basu Active processes make mixed lipid membranes either flat or crumpled New Journal of Physics mixed fluid membrane nonequilibrium statistical mechanics miscibility phase transitions membrane fluctuations continuum hydrodynamic approaches |
| title | Active processes make mixed lipid membranes either flat or crumpled |
| title_full | Active processes make mixed lipid membranes either flat or crumpled |
| title_fullStr | Active processes make mixed lipid membranes either flat or crumpled |
| title_full_unstemmed | Active processes make mixed lipid membranes either flat or crumpled |
| title_short | Active processes make mixed lipid membranes either flat or crumpled |
| title_sort | active processes make mixed lipid membranes either flat or crumpled |
| topic | mixed fluid membrane nonequilibrium statistical mechanics miscibility phase transitions membrane fluctuations continuum hydrodynamic approaches |
| url | https://doi.org/10.1088/1367-2630/aa9ed2 |
| work_keys_str_mv | AT tirthankarbanerjee activeprocessesmakemixedlipidmembraneseitherflatorcrumpled AT abhikbasu activeprocessesmakemixedlipidmembraneseitherflatorcrumpled |