Survival Benefit of Multiple Arterial Revascularization With and Without Supplementary Saphenous Vein Graft
Background It is unknown if the presence of saphenous vein grafting (SVG) adversely affects late survival following coronary surgery with multiple arterial grafting (MAG) versus single arterial grafting. Methods and Results A retrospective, observational, multicenter cohort study from 2001 to 2020 w...
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.031986 |
| _version_ | 1797540958195154944 |
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| author | Justin Ren David H. Tian Mario Gaudino Stephen Fremes Christopher M. Reid Michael Vallely Julian A. Smith Nilesh Srivastav Colin Royse Alistair Royse |
| author_facet | Justin Ren David H. Tian Mario Gaudino Stephen Fremes Christopher M. Reid Michael Vallely Julian A. Smith Nilesh Srivastav Colin Royse Alistair Royse |
| author_sort | Justin Ren |
| collection | DOAJ |
| description | Background It is unknown if the presence of saphenous vein grafting (SVG) adversely affects late survival following coronary surgery with multiple arterial grafting (MAG) versus single arterial grafting. Methods and Results A retrospective, observational, multicenter cohort study from 2001 to 2020 was conducted using the Australian and New Zealand Society of Cardiac and Thoracic Surgeons Database linked to the National Death Index. Patients undergoing primary isolated coronary artery bypass grafting with ≥2 grafts were included, and exclusions were patients aged <18 years, reoperations, concomitant or previous cardiac surgery, and the absence of arterial grafting. Demographics, comorbidities, medication, and operative configurations were propensity score matched between cohorts. The primary outcome was all‐cause late death. Of 59 689 eligible patients, 35 113 were MAG (58.8%), and 24 576 were single arterial grafting (41.2%). Of the MAG cohort, 17 055 (48.6%) patients did not receive supplementary SVG (total arterial revascularization). Matching separately generated 22 764 patient pairs for MAG versus single arterial grafting, and 11 137 patient pairs for MAG with total arterial revascularization versus MAG with ≥1 supplementary vein grafts. At a median follow‐up duration of 5.0 years postoperatively, the mortality rate was significantly lower for MAG than single arterial grafting (hazard ratio [HR], 0.79 [95% CI, 0.76–0.83]; P<0.001). The stratified MAG analysis found that MAG with total arterial revascularization had a lower risk of late death (HR, 0.85 [95% CI, 0.80–0.91]; P<0.001) compared with MAG with ≥1 supplementary vein grafts. Sensitivity analyses produced consistent outcomes as the primary analysis. Following adjustment for the presence of SVG in the Cox model, the survival advantage of incremental number of arteries was lost. Conclusions Multiple arterial grafting has significantly improved long‐term survival compared with single arterial grafting. A further incremental survival benefit exists when no SVG is used. |
| first_indexed | 2024-03-10T13:09:27Z |
| format | Article |
| id | doaj.art-2a55f688c19045918d490c76112e31a6 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-10T13:09:27Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-2a55f688c19045918d490c76112e31a62023-11-21T10:53:12ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-11-01122210.1161/JAHA.123.031986Survival Benefit of Multiple Arterial Revascularization With and Without Supplementary Saphenous Vein GraftJustin Ren0David H. Tian1Mario Gaudino2Stephen Fremes3Christopher M. Reid4Michael Vallely5Julian A. Smith6Nilesh Srivastav7Colin Royse8Alistair Royse9Surgery University of Melbourne Melbourne AustraliaSurgery University of Melbourne Melbourne AustraliaCardiothoracic Surgery, Weill Cornell Medicine New York NYCardiothoracic Surgery University of Toronto CanadaPopulation Health Curtin University Perth AustraliaCardiothoracic Surgery Victorian Heart Hospital and Monash University Melbourne AustraliaCardiothoracic Surgery Victorian Heart Hospital and Monash University Melbourne AustraliaSurgery University of Melbourne Melbourne AustraliaSurgery University of Melbourne Melbourne AustraliaSurgery University of Melbourne Melbourne AustraliaBackground It is unknown if the presence of saphenous vein grafting (SVG) adversely affects late survival following coronary surgery with multiple arterial grafting (MAG) versus single arterial grafting. Methods and Results A retrospective, observational, multicenter cohort study from 2001 to 2020 was conducted using the Australian and New Zealand Society of Cardiac and Thoracic Surgeons Database linked to the National Death Index. Patients undergoing primary isolated coronary artery bypass grafting with ≥2 grafts were included, and exclusions were patients aged <18 years, reoperations, concomitant or previous cardiac surgery, and the absence of arterial grafting. Demographics, comorbidities, medication, and operative configurations were propensity score matched between cohorts. The primary outcome was all‐cause late death. Of 59 689 eligible patients, 35 113 were MAG (58.8%), and 24 576 were single arterial grafting (41.2%). Of the MAG cohort, 17 055 (48.6%) patients did not receive supplementary SVG (total arterial revascularization). Matching separately generated 22 764 patient pairs for MAG versus single arterial grafting, and 11 137 patient pairs for MAG with total arterial revascularization versus MAG with ≥1 supplementary vein grafts. At a median follow‐up duration of 5.0 years postoperatively, the mortality rate was significantly lower for MAG than single arterial grafting (hazard ratio [HR], 0.79 [95% CI, 0.76–0.83]; P<0.001). The stratified MAG analysis found that MAG with total arterial revascularization had a lower risk of late death (HR, 0.85 [95% CI, 0.80–0.91]; P<0.001) compared with MAG with ≥1 supplementary vein grafts. Sensitivity analyses produced consistent outcomes as the primary analysis. Following adjustment for the presence of SVG in the Cox model, the survival advantage of incremental number of arteries was lost. Conclusions Multiple arterial grafting has significantly improved long‐term survival compared with single arterial grafting. A further incremental survival benefit exists when no SVG is used.https://www.ahajournals.org/doi/10.1161/JAHA.123.031986coronary surgerymultiple arterial graftingsingle arterial graftingsurvivaltotal arterial revascularization |
| spellingShingle | Justin Ren David H. Tian Mario Gaudino Stephen Fremes Christopher M. Reid Michael Vallely Julian A. Smith Nilesh Srivastav Colin Royse Alistair Royse Survival Benefit of Multiple Arterial Revascularization With and Without Supplementary Saphenous Vein Graft Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease coronary surgery multiple arterial grafting single arterial grafting survival total arterial revascularization |
| title | Survival Benefit of Multiple Arterial Revascularization With and Without Supplementary Saphenous Vein Graft |
| title_full | Survival Benefit of Multiple Arterial Revascularization With and Without Supplementary Saphenous Vein Graft |
| title_fullStr | Survival Benefit of Multiple Arterial Revascularization With and Without Supplementary Saphenous Vein Graft |
| title_full_unstemmed | Survival Benefit of Multiple Arterial Revascularization With and Without Supplementary Saphenous Vein Graft |
| title_short | Survival Benefit of Multiple Arterial Revascularization With and Without Supplementary Saphenous Vein Graft |
| title_sort | survival benefit of multiple arterial revascularization with and without supplementary saphenous vein graft |
| topic | coronary surgery multiple arterial grafting single arterial grafting survival total arterial revascularization |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.031986 |
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