Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA
Long noncoding RNAs (lncRNAs) are a subclass of noncoding RNAs composed of more than 200 nucleotides without the ability to encode functional proteins. Given their involvement in critical cellular processes such as gene expression regulation, transcription, and translation, lncRNAs play a significan...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/21/15897 |
| _version_ | 1797631773150019584 |
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| author | Seyedeh Tayebeh Ahmadpour Charlotte Orre Priscila Silvana Bertevello Delphine Mirebeau-Prunier Jean-François Dumas Valérie Desquiret-Dumas |
| author_facet | Seyedeh Tayebeh Ahmadpour Charlotte Orre Priscila Silvana Bertevello Delphine Mirebeau-Prunier Jean-François Dumas Valérie Desquiret-Dumas |
| author_sort | Seyedeh Tayebeh Ahmadpour |
| collection | DOAJ |
| description | Long noncoding RNAs (lncRNAs) are a subclass of noncoding RNAs composed of more than 200 nucleotides without the ability to encode functional proteins. Given their involvement in critical cellular processes such as gene expression regulation, transcription, and translation, lncRNAs play a significant role in organism homeostasis. Breast cancer (BC) is the second most common cancer worldwide and evidence has shown a relationship between aberrant lncRNA expression and BC development. One of the main obstacles in BC control is multidrug chemoresistance, which is associated with the deregulation of multiple mechanisms such as efflux transporter activity, mitochondrial metabolism reprogramming, and epigenetic regulation as well as apoptosis and autophagy. Studies have shown the involvement of a large number of lncRNAs in the regulation of such pathways. However, the underlying mechanism is not clearly elucidated. In this review, we present the principal mechanisms associated with BC chemoresistance that can be directly or indirectly regulated by lncRNA, highlighting the importance of lncRNA in controlling BC chemoresistance. Understanding these mechanisms in deep detail may interest the clinical outcome of BC patients and could be used as therapeutic targets to overcome BC therapy resistance. |
| first_indexed | 2024-03-11T11:27:05Z |
| format | Article |
| id | doaj.art-2a560549079c4f2ebf89f5c8a68ba260 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T11:27:05Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2a560549079c4f2ebf89f5c8a68ba2602023-11-10T15:05:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124211589710.3390/ijms242115897Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNASeyedeh Tayebeh Ahmadpour0Charlotte Orre1Priscila Silvana Bertevello2Delphine Mirebeau-Prunier3Jean-François Dumas4Valérie Desquiret-Dumas5Nutrition, Croissance et Cancer, Inserm, UMR1069, Université de Tours, 37032 Tours, FranceInserm U1083, UMR CNRS 6214, Angers University, 49933 Angers, FranceNutrition, Croissance et Cancer, Inserm, UMR1069, Université de Tours, 37032 Tours, FranceInserm U1083, UMR CNRS 6214, Angers University, 49933 Angers, FranceNutrition, Croissance et Cancer, Inserm, UMR1069, Université de Tours, 37032 Tours, FranceInserm U1083, UMR CNRS 6214, Angers University, 49933 Angers, FranceLong noncoding RNAs (lncRNAs) are a subclass of noncoding RNAs composed of more than 200 nucleotides without the ability to encode functional proteins. Given their involvement in critical cellular processes such as gene expression regulation, transcription, and translation, lncRNAs play a significant role in organism homeostasis. Breast cancer (BC) is the second most common cancer worldwide and evidence has shown a relationship between aberrant lncRNA expression and BC development. One of the main obstacles in BC control is multidrug chemoresistance, which is associated with the deregulation of multiple mechanisms such as efflux transporter activity, mitochondrial metabolism reprogramming, and epigenetic regulation as well as apoptosis and autophagy. Studies have shown the involvement of a large number of lncRNAs in the regulation of such pathways. However, the underlying mechanism is not clearly elucidated. In this review, we present the principal mechanisms associated with BC chemoresistance that can be directly or indirectly regulated by lncRNA, highlighting the importance of lncRNA in controlling BC chemoresistance. Understanding these mechanisms in deep detail may interest the clinical outcome of BC patients and could be used as therapeutic targets to overcome BC therapy resistance.https://www.mdpi.com/1422-0067/24/21/15897breast cancerchemoresistancelong noncoding RNAmetabolism |
| spellingShingle | Seyedeh Tayebeh Ahmadpour Charlotte Orre Priscila Silvana Bertevello Delphine Mirebeau-Prunier Jean-François Dumas Valérie Desquiret-Dumas Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA International Journal of Molecular Sciences breast cancer chemoresistance long noncoding RNA metabolism |
| title | Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA |
| title_full | Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA |
| title_fullStr | Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA |
| title_full_unstemmed | Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA |
| title_short | Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA |
| title_sort | breast cancer chemoresistance insights into the regulatory role of lncrna |
| topic | breast cancer chemoresistance long noncoding RNA metabolism |
| url | https://www.mdpi.com/1422-0067/24/21/15897 |
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