CMV Serovirulance in Mothers and Their Very Low Birth Weight (
Background: Cytomegalovirus (CMV) is a pathogenic virus that is found everywhere. The serovirulance of this virus varies widely among different communities. The present study was conducted to investigate the frequency of CMV serovirulance in mothers and their very low birth weight (<1,500 g) neon...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-04-01
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| Series: | Iranian Journal of Neonatology |
| Subjects: | |
| Online Access: | https://ijn.mums.ac.ir/article_20200_02742f1623f4d083836ea3c6de050b42.pdf |
| _version_ | 1828317871201058816 |
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| author | Mohammad Kazemian Mahsa Mehri Minoo Fallahi Maryam Khoshnud Shariati Mahmoud hajipour Ali Nikkhah |
| author_facet | Mohammad Kazemian Mahsa Mehri Minoo Fallahi Maryam Khoshnud Shariati Mahmoud hajipour Ali Nikkhah |
| author_sort | Mohammad Kazemian |
| collection | DOAJ |
| description | Background: Cytomegalovirus (CMV) is a pathogenic virus that is found everywhere. The serovirulance of this virus varies widely among different communities. The present study was conducted to investigate the frequency of CMV serovirulance in mothers and their very low birth weight (<1,500 g) neonates.
Methods: This descriptive cross-sectional study was conducted on 234 serum samples (117 maternal and 117 neonatal samples) for 12 months in Mahdieh Hospital, Tehran, Iran, from March 2019 to March 2020. The enzyme-linked Immunosorbent assay technique was used to evaluate specific antibodies (i.e., immunoglobulin G [IgG] and immunoglobulin M [IgM]) of CMV. Statistical analysis was conducted in SPSS (version 23).
Results: Based on the results, the seroprevalence of CMV IgG was 98.2% (115 cases) in mothers and 84.6% (99 cases) in neonates. The seropositivity rate of CMV IgM was reported at 1.8% (2 cases) in mothers and 0.9% (1 case) in neonates. It was found that the relationship between the mean scores of maternal CMV IgG and the number of live births was statistically significant (P=0.002). However, there was no statistically significant relationship between some maternal factors (e.g., age, occupation, living place, number of pregnancies, deliveries, abortions, and education) and maternal CMV IgM seropositivity. Furthermore, neonatal gender and gestational age showed no statistically significant relationship with maternal and neonatal CMV IgG and IgM seropositivity.
Conclusion: According to our findings, the serovirulance of CMV in mothers and their neonates was significant, whereas active CMV infection in both groups was highly unusual. Additionally, the transmission rate of CMV IgG and CMV IgM from the mother to her neonate was incomplete. |
| first_indexed | 2024-04-13T17:33:59Z |
| format | Article |
| id | doaj.art-2a56158c735942c4b8b6a1632d11bc6c |
| institution | Directory Open Access Journal |
| issn | 2251-7510 2322-2158 |
| language | English |
| last_indexed | 2024-04-13T17:33:59Z |
| publishDate | 2022-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Neonatology |
| spelling | doaj.art-2a56158c735942c4b8b6a1632d11bc6c2022-12-22T02:37:27ZengMashhad University of Medical SciencesIranian Journal of Neonatology2251-75102322-21582022-04-01132798310.22038/ijn.2022.57840.208620200CMV Serovirulance in Mothers and Their Very Low Birth Weight (Mohammad Kazemian0Mahsa Mehri1Minoo Fallahi2Maryam Khoshnud Shariati3Mahmoud hajipour4Ali Nikkhah5Neonatal Health Research Center, Research Institute for Children's Health, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranNeonatal Health Research Center, Research Institute for Children's Health, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranNeonatal Health Research Center, Research Institute for Children's Health, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Neonatal Health Institute. Mahdieh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pediatric Neurology Research Center, Research Institute for Children's Health, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground: Cytomegalovirus (CMV) is a pathogenic virus that is found everywhere. The serovirulance of this virus varies widely among different communities. The present study was conducted to investigate the frequency of CMV serovirulance in mothers and their very low birth weight (<1,500 g) neonates. Methods: This descriptive cross-sectional study was conducted on 234 serum samples (117 maternal and 117 neonatal samples) for 12 months in Mahdieh Hospital, Tehran, Iran, from March 2019 to March 2020. The enzyme-linked Immunosorbent assay technique was used to evaluate specific antibodies (i.e., immunoglobulin G [IgG] and immunoglobulin M [IgM]) of CMV. Statistical analysis was conducted in SPSS (version 23). Results: Based on the results, the seroprevalence of CMV IgG was 98.2% (115 cases) in mothers and 84.6% (99 cases) in neonates. The seropositivity rate of CMV IgM was reported at 1.8% (2 cases) in mothers and 0.9% (1 case) in neonates. It was found that the relationship between the mean scores of maternal CMV IgG and the number of live births was statistically significant (P=0.002). However, there was no statistically significant relationship between some maternal factors (e.g., age, occupation, living place, number of pregnancies, deliveries, abortions, and education) and maternal CMV IgM seropositivity. Furthermore, neonatal gender and gestational age showed no statistically significant relationship with maternal and neonatal CMV IgG and IgM seropositivity. Conclusion: According to our findings, the serovirulance of CMV in mothers and their neonates was significant, whereas active CMV infection in both groups was highly unusual. Additionally, the transmission rate of CMV IgG and CMV IgM from the mother to her neonate was incomplete.https://ijn.mums.ac.ir/article_20200_02742f1623f4d083836ea3c6de050b42.pdfcytomegalovirusneonatesserovirulancevery low birth weight |
| spellingShingle | Mohammad Kazemian Mahsa Mehri Minoo Fallahi Maryam Khoshnud Shariati Mahmoud hajipour Ali Nikkhah CMV Serovirulance in Mothers and Their Very Low Birth Weight ( Iranian Journal of Neonatology cytomegalovirus neonates serovirulance very low birth weight |
| title | CMV Serovirulance in Mothers and Their Very Low Birth Weight ( |
| title_full | CMV Serovirulance in Mothers and Their Very Low Birth Weight ( |
| title_fullStr | CMV Serovirulance in Mothers and Their Very Low Birth Weight ( |
| title_full_unstemmed | CMV Serovirulance in Mothers and Their Very Low Birth Weight ( |
| title_short | CMV Serovirulance in Mothers and Their Very Low Birth Weight ( |
| title_sort | cmv serovirulance in mothers and their very low birth weight |
| topic | cytomegalovirus neonates serovirulance very low birth weight |
| url | https://ijn.mums.ac.ir/article_20200_02742f1623f4d083836ea3c6de050b42.pdf |
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