Do racial differences exist in the association between pregnancy-induced hypertension and breast cancer risk?
Background: Previous studies investigating the relationship between pregnancy-induced hypertension (PIH) and breast cancer risk have yielded inconsistent results. Unlike numerous Western studies, studies have reported that PIH may be a risk factor for breast cancer in Western Asian women. To confirm...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-04-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2016.1258411 |
| _version_ | 1797681568654819328 |
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| author | Li-Te Lin Li-Yu Hu Pei-Ling Tang Kuan-Hao Tsui Jiin-Tsuey Cheng Wei-Chun Huang Hong-Tai Chang |
| author_facet | Li-Te Lin Li-Yu Hu Pei-Ling Tang Kuan-Hao Tsui Jiin-Tsuey Cheng Wei-Chun Huang Hong-Tai Chang |
| author_sort | Li-Te Lin |
| collection | DOAJ |
| description | Background: Previous studies investigating the relationship between pregnancy-induced hypertension (PIH) and breast cancer risk have yielded inconsistent results. Unlike numerous Western studies, studies have reported that PIH may be a risk factor for breast cancer in Western Asian women. To confirm these results, we designed a retrospective population-based cohort study to assess the relationship between PIH and subsequent risk for breast cancer in Taiwan. Methods: Patients with newly diagnosed PIH were selected from the Taiwan National Health Insurance Research Database (NHIRD), and a 1:4 matched cohort of women without PIH based on age and the year of delivery was randomly selected from the same database as the comparison group. The incidence of new-onset breast cancer was assessed in both cohorts. Results: Among the 23.3 million individuals registered in the NHIRD, 26,638 patients with PIH and 106,552 matched controls were identified. The incidence rate of breast cancer was higher in patients with PIH than in the matched controls (incidence rate ratio = 1.09, 95% confidence interval [CI] = 1.09–1.10, p < 0.0001). However, the Kaplan–Meier analysis revealed a similar cumulative incidence rate of breast cancer between the PIH and comparison cohorts (log-rank p = 0.4303). Moreover, results from a multivariate analysis indicated that PIH was not a statistically significant independent risk factor for breast cancer (adjusted hazard ratio = 1.10, 95% CI = 0.87–1.39, p = 0.4247). Conclusions: The present study demonstrated no significant temporal relationship between PIH and risk for subsequent breast cancer in Eastern Asian women. |
| first_indexed | 2024-03-11T23:46:47Z |
| format | Article |
| id | doaj.art-2a56a40e0dcb4da3a68329b8044fca03 |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:46:47Z |
| publishDate | 2017-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-2a56a40e0dcb4da3a68329b8044fca032023-09-19T09:24:42ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652017-04-0136213814410.1080/10641955.2016.12584111258411Do racial differences exist in the association between pregnancy-induced hypertension and breast cancer risk?Li-Te Lin0Li-Yu Hu1Pei-Ling Tang2Kuan-Hao Tsui3Jiin-Tsuey Cheng4Wei-Chun Huang5Hong-Tai Chang6Kaohsiung Veterans General HospitalNational Yang-Ming UniversityKaohsiung Veterans General HospitalKaohsiung Veterans General HospitalNational Sun Yat-sen UniversityNational Yang-Ming UniversityKaohsiung Veterans General HospitalBackground: Previous studies investigating the relationship between pregnancy-induced hypertension (PIH) and breast cancer risk have yielded inconsistent results. Unlike numerous Western studies, studies have reported that PIH may be a risk factor for breast cancer in Western Asian women. To confirm these results, we designed a retrospective population-based cohort study to assess the relationship between PIH and subsequent risk for breast cancer in Taiwan. Methods: Patients with newly diagnosed PIH were selected from the Taiwan National Health Insurance Research Database (NHIRD), and a 1:4 matched cohort of women without PIH based on age and the year of delivery was randomly selected from the same database as the comparison group. The incidence of new-onset breast cancer was assessed in both cohorts. Results: Among the 23.3 million individuals registered in the NHIRD, 26,638 patients with PIH and 106,552 matched controls were identified. The incidence rate of breast cancer was higher in patients with PIH than in the matched controls (incidence rate ratio = 1.09, 95% confidence interval [CI] = 1.09–1.10, p < 0.0001). However, the Kaplan–Meier analysis revealed a similar cumulative incidence rate of breast cancer between the PIH and comparison cohorts (log-rank p = 0.4303). Moreover, results from a multivariate analysis indicated that PIH was not a statistically significant independent risk factor for breast cancer (adjusted hazard ratio = 1.10, 95% CI = 0.87–1.39, p = 0.4247). Conclusions: The present study demonstrated no significant temporal relationship between PIH and risk for subsequent breast cancer in Eastern Asian women.http://dx.doi.org/10.1080/10641955.2016.1258411breast cancerepidemiologygestational hypertensionpreeclampsiapregnancy-induced hypertension |
| spellingShingle | Li-Te Lin Li-Yu Hu Pei-Ling Tang Kuan-Hao Tsui Jiin-Tsuey Cheng Wei-Chun Huang Hong-Tai Chang Do racial differences exist in the association between pregnancy-induced hypertension and breast cancer risk? Hypertension in Pregnancy breast cancer epidemiology gestational hypertension preeclampsia pregnancy-induced hypertension |
| title | Do racial differences exist in the association between pregnancy-induced hypertension and breast cancer risk? |
| title_full | Do racial differences exist in the association between pregnancy-induced hypertension and breast cancer risk? |
| title_fullStr | Do racial differences exist in the association between pregnancy-induced hypertension and breast cancer risk? |
| title_full_unstemmed | Do racial differences exist in the association between pregnancy-induced hypertension and breast cancer risk? |
| title_short | Do racial differences exist in the association between pregnancy-induced hypertension and breast cancer risk? |
| title_sort | do racial differences exist in the association between pregnancy induced hypertension and breast cancer risk |
| topic | breast cancer epidemiology gestational hypertension preeclampsia pregnancy-induced hypertension |
| url | http://dx.doi.org/10.1080/10641955.2016.1258411 |
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