The Relationship between Nifedipine and Postpartum Blood Loss in Patients with Preterm Labor
Background: The purpose of the study, to determine whether exposure to nifedipine before delivery is associated with an increased risk of postpartum blood loss in patients with preterm labor. Methods: This was a retrospective study screening a total of 486 patients who were admitted due to preterm l...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-10-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/50/11/10.31083/j.ceog5011225 |
| _version_ | 1827592909489176576 |
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| author | Huseyin Kiyak Nazli Korkmaz Sema Suzen Caypinar Zuat Acar Alev Atis Aydin Batuhan Ustun Zubeyde Aytufan Ali Gedikbasi |
| author_facet | Huseyin Kiyak Nazli Korkmaz Sema Suzen Caypinar Zuat Acar Alev Atis Aydin Batuhan Ustun Zubeyde Aytufan Ali Gedikbasi |
| author_sort | Huseyin Kiyak |
| collection | DOAJ |
| description | Background: The purpose of the study, to determine whether exposure to nifedipine before delivery is associated with an increased risk of postpartum blood loss in patients with preterm labor. Methods: This was a retrospective study screening a total of 486 patients who were admitted due to preterm labor from 2012 to 2019. Patients who were given nifedipine for tocolysis before delivery were considered as the study group (n: 240), and the patients who gave birth without getting tocolysis were considered as the control group (n: 246). The dose of nifedipine used during the last 24 hours, 72 hours and 1 week before delivery, the total dose of nifedipine given and the duration from the last dose to the delivery were recorded separately. Hemoglobin and hematocrit and platelet values measured before and 6 hours after delivery were recorded and postpartum bleeding amount was calculated. Results: No significant difference is observed in terms of mean difference between pre/postpartum hemoglobin and hematocrit levels between control group and nifedipine group (p > 0.05). But when subgroups that are created according to the time of use of nifedipine before delivery, a positive correlation was observed between difference in hemoglobin and hematocrit levels between prepartum and postpartum and nifedipine dosage for the last 24 hours (r = 0.176, p = 0.006), (r = 0.139, p = 0.030), but not for 72 hours or one week. Conclusions: The use of nifedipine in patients with preterm labor for tocolysis may be associated with increase in postpartum blood loss in the last 24 hours before delivery. |
| first_indexed | 2024-03-09T02:02:32Z |
| format | Article |
| id | doaj.art-2a591ce1dd1b4c829769312740f443f5 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-09T02:02:32Z |
| publishDate | 2023-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-2a591ce1dd1b4c829769312740f443f52023-12-08T02:49:16ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-10-01501122510.31083/j.ceog5011225S0390-6663(23)02208-XThe Relationship between Nifedipine and Postpartum Blood Loss in Patients with Preterm LaborHuseyin Kiyak0Nazli Korkmaz1Sema Suzen Caypinar2Zuat Acar3Alev Atis Aydin4Batuhan Ustun5Zubeyde Aytufan6Ali Gedikbasi7Department of Obstetrics and Gynecology, Sarıyer Hamidiye Etfal Education ve Research Hospital, 34453 Istanbul, TurkeyDepartment of Obstetrics and Gynecology, Demiroglu Bilim University, 34394 Istanbul, TurkeyDepartment of Maternal Fetal Medicine, Kanuni Sultan Süleyman Education ve Research Hospital, 34303 Istanbul, TurkeyDepartment of Maternal Fetal Medicine, Istanbul Tema Hospital, 34307 Istanbul, TurkeyDepartment of Maternal Fetal Medicine, Sarıyer Hamidiye Etfal Education ve Research Hospital, 34453 Istanbul, TurkeyDepartment of Obstetrics and Gynecology, Namik Kemal University, 59030 Tekirdag, TurkeyDepartment of Maternal Fetal Medicine, Goztepe Medical Park, 34732 Istanbul, TurkeyDepartment of Maternal Fetal Medicine, Special Clinic Fulya Terrace, 34365 Istanbul, TurkeyBackground: The purpose of the study, to determine whether exposure to nifedipine before delivery is associated with an increased risk of postpartum blood loss in patients with preterm labor. Methods: This was a retrospective study screening a total of 486 patients who were admitted due to preterm labor from 2012 to 2019. Patients who were given nifedipine for tocolysis before delivery were considered as the study group (n: 240), and the patients who gave birth without getting tocolysis were considered as the control group (n: 246). The dose of nifedipine used during the last 24 hours, 72 hours and 1 week before delivery, the total dose of nifedipine given and the duration from the last dose to the delivery were recorded separately. Hemoglobin and hematocrit and platelet values measured before and 6 hours after delivery were recorded and postpartum bleeding amount was calculated. Results: No significant difference is observed in terms of mean difference between pre/postpartum hemoglobin and hematocrit levels between control group and nifedipine group (p > 0.05). But when subgroups that are created according to the time of use of nifedipine before delivery, a positive correlation was observed between difference in hemoglobin and hematocrit levels between prepartum and postpartum and nifedipine dosage for the last 24 hours (r = 0.176, p = 0.006), (r = 0.139, p = 0.030), but not for 72 hours or one week. Conclusions: The use of nifedipine in patients with preterm labor for tocolysis may be associated with increase in postpartum blood loss in the last 24 hours before delivery.https://www.imrpress.com/journal/CEOG/50/11/10.31083/j.ceog5011225nifedipinepostpartum hemorrhagepreterm laborcalcium channel blockers |
| spellingShingle | Huseyin Kiyak Nazli Korkmaz Sema Suzen Caypinar Zuat Acar Alev Atis Aydin Batuhan Ustun Zubeyde Aytufan Ali Gedikbasi The Relationship between Nifedipine and Postpartum Blood Loss in Patients with Preterm Labor Clinical and Experimental Obstetrics & Gynecology nifedipine postpartum hemorrhage preterm labor calcium channel blockers |
| title | The Relationship between Nifedipine and Postpartum Blood Loss in Patients with Preterm Labor |
| title_full | The Relationship between Nifedipine and Postpartum Blood Loss in Patients with Preterm Labor |
| title_fullStr | The Relationship between Nifedipine and Postpartum Blood Loss in Patients with Preterm Labor |
| title_full_unstemmed | The Relationship between Nifedipine and Postpartum Blood Loss in Patients with Preterm Labor |
| title_short | The Relationship between Nifedipine and Postpartum Blood Loss in Patients with Preterm Labor |
| title_sort | relationship between nifedipine and postpartum blood loss in patients with preterm labor |
| topic | nifedipine postpartum hemorrhage preterm labor calcium channel blockers |
| url | https://www.imrpress.com/journal/CEOG/50/11/10.31083/j.ceog5011225 |
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