Identification of Genetic Modifiers of TDP-43: Inflammatory Activation of Astrocytes for Neuroinflammation

Identification of Genetic Modifiers of TDP-43: Inflammatory Activation of Astrocytes for Neuroinflammation

Transactive response DNA-binding protein 43 (TDP-43) is a ubiquitously expressed DNA/RNA-binding protein linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 has been implicated in numerous aspects of the mRNA life cycle, as well as in cell toxicity and neuroinflam...

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Bibliographic Details
Main Authors:	Jae-Hong Kim, Md Habibur Rahman, Donghwi Park, Myungjin Jo, Hyung-Jun Kim, Kyoungho Suk
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	Cells
Subjects:	TDP-43 astrocyte glia neuroinflammation genetic interaction amyotrophic lateral sclerosis
Online Access:	https://www.mdpi.com/2073-4409/10/3/676

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