Assessment of probability of pulmonary arterial hypertension among HIV-1 infected patients on HAART and its relationship with CD4 cells Count and viral load
Background: HIV patients are more likely to develop cardiovascular disease than the general population and have a 2500-fold increased risk of developing pulmonary artery hypertension (PAH). HIV associated pulmonary hypertension was said to be more severe and is associated with higher mortality. Meth...
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| Format: | Article |
| Language: | English |
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Ntec Specialist
2021-11-01
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| Series: | Kanem Journal of Medical Sciences |
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| Online Access: | https://www.ajol.info/index.php/kjms/article/view/223790/211121 |
| _version_ | 1811190236162555904 |
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| author | Musa M. Baba Faruk Buba Mohammed A. Talle Hayatu Umar Musa A. Garbati Habu Abdul |
| author_facet | Musa M. Baba Faruk Buba Mohammed A. Talle Hayatu Umar Musa A. Garbati Habu Abdul |
| author_sort | Musa M. Baba |
| collection | DOAJ |
| description | Background: HIV patients are more likely to develop cardiovascular disease than the general population
and have a 2500-fold increased risk of developing pulmonary artery hypertension (PAH). HIV associated
pulmonary hypertension was said to be more severe and is associated with higher mortality. Methodology:
Across-sectional conducted among consecutive HIV patients age greater than 18 years receiving treatment
at the antiretroviral therapy (ART) clinic of the Federal Medical Centre Nguru Yobe State Northeastern
Nigeria. Results: One hundred and twenty (120) subjects were recruited into the study, thirteen had
incomplete data and were excluded from the analysis. There was a significant negative correlation between
CD4 cells count with tricuspid regurgitant flow velocity (TRv), pulmonary regurgitant flow velocity (PRv),
pulmonary artery trunk diameter (PATd), right ventricular to left ventricular internal diameter (RV/LV)
ratio, left ventricular eccentricity index (LVEI), and right atrial area (RAA), while the correlation between
CD4 cells count and right ventricular acceleration time (RVAT) was positive and significant. On the other
hand, the correlations between viral load and TRv, PRv, PATd, RV/LV ratio, and RAA were positive and
significant while that between viral load and RVAT was negative and significant. Conclusions: This study
revealed that HIV patients with low CD4 cell count and high viral load had a high probability of developing
PAH ( significant negative relationship between variables associated with the probability of PAH with CD4
cell count and significant positive relationship with viral load), In HIV patients the probability of
developing PAH decreases with adequate treatment (that suppress viral replication and increases CD4
count). We, therefore, recommend routine assessment of the probability of PAH in patients with HIV
infection particularly those with low CD4 cell count and high viral load and encourage early
commencement of HAART to prevent the development of pulmonary arterial hypertension. |
| first_indexed | 2024-04-11T14:46:51Z |
| format | Article |
| id | doaj.art-2a5e56db6da6493abbe93974326328ff |
| institution | Directory Open Access Journal |
| issn | 2006-4772 2714-2426 |
| language | English |
| last_indexed | 2024-04-11T14:46:51Z |
| publishDate | 2021-11-01 |
| publisher | Ntec Specialist |
| record_format | Article |
| series | Kanem Journal of Medical Sciences |
| spelling | doaj.art-2a5e56db6da6493abbe93974326328ff2022-12-22T04:17:35ZengNtec SpecialistKanem Journal of Medical Sciences2006-47722714-24262021-11-01152124131doi.org/10.36020/kjms.2021.1502.00720212Assessment of probability of pulmonary arterial hypertension among HIV-1 infected patients on HAART and its relationship with CD4 cells Count and viral loadMusa M. Baba0Faruk Buba1Mohammed A. Talle2Hayatu Umar3Musa A. Garbati4Habu Abdul5Department of Internal Medicine, Federal Medical Centre Nguru, Nguru, Yobe State, NigeriaDepartment of Medicine, College of Medical Sciences, University of Maiduguri, Maiduguri, Borno State, NigeriaDepartment of Medicine, College of Medical Sciences, University of Maiduguri, Maiduguri, Borno State, NigeriaDepartment of Medicine, Usman Danfodiyo University Teaching Hospital SokotoDepartment of Medicine, College of Medical Sciences, University of Maiduguri, Maiduguri, Borno State, NigeriaDepartment of Internal Medicine, Federal Medical Centre Nguru, Nguru, Yobe State, NigeriaBackground: HIV patients are more likely to develop cardiovascular disease than the general population and have a 2500-fold increased risk of developing pulmonary artery hypertension (PAH). HIV associated pulmonary hypertension was said to be more severe and is associated with higher mortality. Methodology: Across-sectional conducted among consecutive HIV patients age greater than 18 years receiving treatment at the antiretroviral therapy (ART) clinic of the Federal Medical Centre Nguru Yobe State Northeastern Nigeria. Results: One hundred and twenty (120) subjects were recruited into the study, thirteen had incomplete data and were excluded from the analysis. There was a significant negative correlation between CD4 cells count with tricuspid regurgitant flow velocity (TRv), pulmonary regurgitant flow velocity (PRv), pulmonary artery trunk diameter (PATd), right ventricular to left ventricular internal diameter (RV/LV) ratio, left ventricular eccentricity index (LVEI), and right atrial area (RAA), while the correlation between CD4 cells count and right ventricular acceleration time (RVAT) was positive and significant. On the other hand, the correlations between viral load and TRv, PRv, PATd, RV/LV ratio, and RAA were positive and significant while that between viral load and RVAT was negative and significant. Conclusions: This study revealed that HIV patients with low CD4 cell count and high viral load had a high probability of developing PAH ( significant negative relationship between variables associated with the probability of PAH with CD4 cell count and significant positive relationship with viral load), In HIV patients the probability of developing PAH decreases with adequate treatment (that suppress viral replication and increases CD4 count). We, therefore, recommend routine assessment of the probability of PAH in patients with HIV infection particularly those with low CD4 cell count and high viral load and encourage early commencement of HAART to prevent the development of pulmonary arterial hypertension.https://www.ajol.info/index.php/kjms/article/view/223790/211121cd4 cells counthaarthivngurupulmonary hypertensionviral load |
| spellingShingle | Musa M. Baba Faruk Buba Mohammed A. Talle Hayatu Umar Musa A. Garbati Habu Abdul Assessment of probability of pulmonary arterial hypertension among HIV-1 infected patients on HAART and its relationship with CD4 cells Count and viral load Kanem Journal of Medical Sciences cd4 cells count haart hiv nguru pulmonary hypertension viral load |
| title | Assessment of probability of pulmonary arterial hypertension among HIV-1 infected patients on HAART and its relationship with CD4 cells Count and viral load |
| title_full | Assessment of probability of pulmonary arterial hypertension among HIV-1 infected patients on HAART and its relationship with CD4 cells Count and viral load |
| title_fullStr | Assessment of probability of pulmonary arterial hypertension among HIV-1 infected patients on HAART and its relationship with CD4 cells Count and viral load |
| title_full_unstemmed | Assessment of probability of pulmonary arterial hypertension among HIV-1 infected patients on HAART and its relationship with CD4 cells Count and viral load |
| title_short | Assessment of probability of pulmonary arterial hypertension among HIV-1 infected patients on HAART and its relationship with CD4 cells Count and viral load |
| title_sort | assessment of probability of pulmonary arterial hypertension among hiv 1 infected patients on haart and its relationship with cd4 cells count and viral load |
| topic | cd4 cells count haart hiv nguru pulmonary hypertension viral load |
| url | https://www.ajol.info/index.php/kjms/article/view/223790/211121 |
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