Administration of 3% Sodium Chloride and Local Infusion Reactions
Three-percent sodium chloride (3% NaCl) is a hyperosmolar agent used to treat hyponatremic encephalopathy or other cases of increased intracranial pressure. A barrier to the use of 3% NaCl is the perceived risk of local infusion reactions when administered through a peripheral vein. We sought to eva...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/8/1245 |
| _version_ | 1827600408576524288 |
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| author | Michael L. Moritz Juan C. Ayus Joel B. Nelson |
| author_facet | Michael L. Moritz Juan C. Ayus Joel B. Nelson |
| author_sort | Michael L. Moritz |
| collection | DOAJ |
| description | Three-percent sodium chloride (3% NaCl) is a hyperosmolar agent used to treat hyponatremic encephalopathy or other cases of increased intracranial pressure. A barrier to the use of 3% NaCl is the perceived risk of local infusion reactions when administered through a peripheral vein. We sought to evaluate reports of local infusion reactions associated with 3% NaCl over a 10-year period throughout a large healthcare system. A query was conducted through the Risk Master database to determine if there were any local infusion reactions associated with peripheral 3% NaCl administration throughout the entire UPMC health system, which consists of 40 hospitals with 8400 licensed beds, over a 10-year time period from 14 May 2010 to 14 May 2020. Search terms included infiltrations, extravasations, phlebitis, IV site issues, and IV solutions. There were 23,714 non-chemotherapeutic and non-contrast-associated intravenous events, of which 4678 (19.7%) were at UPMC Children’s Hospital. A total of 2306 patients received 3% NaCl, of whom 836 (35.8%) were at UPMC Children’s Hospital. There were no reported local infusion reactions with 3% NaCl. There were no reported local infusion reaction events associated with 3% NaCl in a large healthcare system over a 10-year period. This suggests that 3% NaCl can be safely administered through a peripheral IV or central venous catheter. |
| first_indexed | 2024-03-09T04:35:37Z |
| format | Article |
| id | doaj.art-2a603e2b8c81461d98e0d0c0cbf64604 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T04:35:37Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-2a603e2b8c81461d98e0d0c0cbf646042023-12-03T13:28:47ZengMDPI AGChildren2227-90672022-08-0198124510.3390/children9081245Administration of 3% Sodium Chloride and Local Infusion ReactionsMichael L. Moritz0Juan C. Ayus1Joel B. Nelson2Division of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USADivision of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine, Orange, CA 92617, USADepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USAThree-percent sodium chloride (3% NaCl) is a hyperosmolar agent used to treat hyponatremic encephalopathy or other cases of increased intracranial pressure. A barrier to the use of 3% NaCl is the perceived risk of local infusion reactions when administered through a peripheral vein. We sought to evaluate reports of local infusion reactions associated with 3% NaCl over a 10-year period throughout a large healthcare system. A query was conducted through the Risk Master database to determine if there were any local infusion reactions associated with peripheral 3% NaCl administration throughout the entire UPMC health system, which consists of 40 hospitals with 8400 licensed beds, over a 10-year time period from 14 May 2010 to 14 May 2020. Search terms included infiltrations, extravasations, phlebitis, IV site issues, and IV solutions. There were 23,714 non-chemotherapeutic and non-contrast-associated intravenous events, of which 4678 (19.7%) were at UPMC Children’s Hospital. A total of 2306 patients received 3% NaCl, of whom 836 (35.8%) were at UPMC Children’s Hospital. There were no reported local infusion reactions with 3% NaCl. There were no reported local infusion reaction events associated with 3% NaCl in a large healthcare system over a 10-year period. This suggests that 3% NaCl can be safely administered through a peripheral IV or central venous catheter.https://www.mdpi.com/2227-9067/9/8/1245hypertonic salineintravenousinfiltrationextravasationhyponatremia |
| spellingShingle | Michael L. Moritz Juan C. Ayus Joel B. Nelson Administration of 3% Sodium Chloride and Local Infusion Reactions Children hypertonic saline intravenous infiltration extravasation hyponatremia |
| title | Administration of 3% Sodium Chloride and Local Infusion Reactions |
| title_full | Administration of 3% Sodium Chloride and Local Infusion Reactions |
| title_fullStr | Administration of 3% Sodium Chloride and Local Infusion Reactions |
| title_full_unstemmed | Administration of 3% Sodium Chloride and Local Infusion Reactions |
| title_short | Administration of 3% Sodium Chloride and Local Infusion Reactions |
| title_sort | administration of 3 sodium chloride and local infusion reactions |
| topic | hypertonic saline intravenous infiltration extravasation hyponatremia |
| url | https://www.mdpi.com/2227-9067/9/8/1245 |
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