Longitudinal characterization of primary osteosarcoma and derived subcutaneous and orthotopic relapsed patient-derived xenograft models

Longitudinal characterization of primary osteosarcoma and derived subcutaneous and orthotopic relapsed patient-derived xenograft models

Osteosarcoma is a rare bone cancer in adolescents and young adults with a dismal prognosis because of metastatic disease and chemoresistance. Despite multiple clinical trials, no improvement in outcome has occurred in decades. There is an urgent need to better understand resistant and metastatic dis...

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Bibliographic Details
Main Authors: Maria Eugenia Marques da Costa, Robin Droit, Pierre Khneisser, Anne Gomez-Brouchet, Tiphaine Adam-de-Beaumais, Marie Nolla, Nicolas Signolles, Jacob Torrejon, Bérangère Lombard, Damarys Loew, Olivier Ayrault, Jean-Yves Scoazec, Birgit Geoerger, Gilles Vassal, Antonin Marchais, Nathalie Gaspar
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Oncology
Subjects:
osteosarcoma
patient-derived xenograft
bone
omics
RNAseq
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1166063/full

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