Detection of classical BSE prions in asymptomatic cows after inoculation with atypical/Nor98 scrapie

Detection of classical BSE prions in asymptomatic cows after inoculation with atypical/Nor98 scrapie

Abstract The emergence of bovine spongiform encephalopathy (BSE) prions from atypical scrapie has been recently observed upon experimental transmission to rodent and swine models. This study aimed to assess whether the inoculation of atypical scrapie could induce BSE-like disease in cattle. Four cal...

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Bibliographic Details
Main Authors: Marina Betancor, Belén Marín, Alicia Otero, Carlos Hedman, Antonio Romero, Tomás Barrio, Eloisa Sevilla, Jean-Yves Douet, Alvina Huor, Juan José Badiola, Olivier Andréoletti, Rosa Bolea
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Veterinary Research
Subjects:
Prion
PrPSc
atypical scrapie
bovine spongiform encephalopathy
Online Access:https://doi.org/10.1186/s13567-023-01225-2
Description
Summary:Abstract The emergence of bovine spongiform encephalopathy (BSE) prions from atypical scrapie has been recently observed upon experimental transmission to rodent and swine models. This study aimed to assess whether the inoculation of atypical scrapie could induce BSE-like disease in cattle. Four calves were intracerebrally challenged with atypical scrapie. Animals were euthanized without clinical signs of prion disease and tested negative for PrPSc accumulation by immunohistochemistry and western blotting. However, an emergence of BSE-like prion seeding activity was detected during in vitro propagation of brain samples from the inoculated animals. These findings suggest that atypical scrapie may represent a potential source of BSE infection in cattle.
ISSN:1297-9716

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