Crosstalk between biological and chemical diversity with cytotoxic and cytostatic effects of Aphanothece halophytica in vitro
Abstract Different solvent extracts from Aphanothece halophytica (A. halophytica) were evaluated for their cytotoxic effects against four human cancer cell lines. The samples demonstrated different percentages of cyanobacteria species populations. The samples containing 100% A. halophytica and 90% A...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2022-12-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000800801&tlng=en |
| _version_ | 1811294299789197312 |
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| author | ISABEL V.G SILVA KARINA L. SILVA RAQUEL C. MAIA HEITOR M. DUARTE RICARDO COUTINHO MARIA HELENA C.B NEVES ANGELICA R. SOARES GISELLE P.F. LOPES |
| author_facet | ISABEL V.G SILVA KARINA L. SILVA RAQUEL C. MAIA HEITOR M. DUARTE RICARDO COUTINHO MARIA HELENA C.B NEVES ANGELICA R. SOARES GISELLE P.F. LOPES |
| author_sort | ISABEL V.G SILVA |
| collection | DOAJ |
| description | Abstract Different solvent extracts from Aphanothece halophytica (A. halophytica) were evaluated for their cytotoxic effects against four human cancer cell lines. The samples demonstrated different percentages of cyanobacteria species populations. The samples containing 100% A. halophytica and 90% A. halophytica showed a significant cytotoxic effect in human breast cancer cells MDA231. The cytostatic effect was demonstrated in MDA231 and human glioblastoma T98G cells regardless of the treatment, resulting in a significant cell cycle arrest in the S phase. The chemical profiles of the extracts were proven to be diverse in qualitative and quantitative compositions. This variability was dependent on the A. halophytica´s abundance in each extract. The 100% A. halophytica extract induced cytotoxic and cytostatic effects in breast cancer cells, and those could be associated with the predominance of fatty acids, hydrocarbons and phthalates, indicating that A. halophytica is an interesting source of novel compound with anticancer effect. |
| first_indexed | 2024-04-13T05:15:25Z |
| format | Article |
| id | doaj.art-2a678589aaac4f23a0ebd17aedf6c5a3 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-13T05:15:25Z |
| publishDate | 2022-12-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-2a678589aaac4f23a0ebd17aedf6c5a32022-12-22T03:00:55ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902022-12-0194suppl 410.1590/0001-3765202220211585Crosstalk between biological and chemical diversity with cytotoxic and cytostatic effects of Aphanothece halophytica in vitroISABEL V.G SILVAhttps://orcid.org/0000-0002-4284-0038KARINA L. SILVAhttps://orcid.org/0000-0002-9300-4398RAQUEL C. MAIAhttps://orcid.org/0000-0003-0225-471XHEITOR M. DUARTEhttps://orcid.org/0000-0003-0088-6596RICARDO COUTINHOhttps://orcid.org/0000-0001-5430-2176MARIA HELENA C.B NEVEShttps://orcid.org/0000-0003-1481-4155ANGELICA R. SOAREShttps://orcid.org/0000-0001-9126-3778GISELLE P.F. LOPEShttps://orcid.org/0000-0001-9502-2314Abstract Different solvent extracts from Aphanothece halophytica (A. halophytica) were evaluated for their cytotoxic effects against four human cancer cell lines. The samples demonstrated different percentages of cyanobacteria species populations. The samples containing 100% A. halophytica and 90% A. halophytica showed a significant cytotoxic effect in human breast cancer cells MDA231. The cytostatic effect was demonstrated in MDA231 and human glioblastoma T98G cells regardless of the treatment, resulting in a significant cell cycle arrest in the S phase. The chemical profiles of the extracts were proven to be diverse in qualitative and quantitative compositions. This variability was dependent on the A. halophytica´s abundance in each extract. The 100% A. halophytica extract induced cytotoxic and cytostatic effects in breast cancer cells, and those could be associated with the predominance of fatty acids, hydrocarbons and phthalates, indicating that A. halophytica is an interesting source of novel compound with anticancer effect.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000800801&tlng=enAphanothece halophyticabiodiversitysecondary metabolitescytotoxiccytostatic |
| spellingShingle | ISABEL V.G SILVA KARINA L. SILVA RAQUEL C. MAIA HEITOR M. DUARTE RICARDO COUTINHO MARIA HELENA C.B NEVES ANGELICA R. SOARES GISELLE P.F. LOPES Crosstalk between biological and chemical diversity with cytotoxic and cytostatic effects of Aphanothece halophytica in vitro Anais da Academia Brasileira de Ciências Aphanothece halophytica biodiversity secondary metabolites cytotoxic cytostatic |
| title | Crosstalk between biological and chemical diversity with cytotoxic and cytostatic effects of Aphanothece halophytica in vitro |
| title_full | Crosstalk between biological and chemical diversity with cytotoxic and cytostatic effects of Aphanothece halophytica in vitro |
| title_fullStr | Crosstalk between biological and chemical diversity with cytotoxic and cytostatic effects of Aphanothece halophytica in vitro |
| title_full_unstemmed | Crosstalk between biological and chemical diversity with cytotoxic and cytostatic effects of Aphanothece halophytica in vitro |
| title_short | Crosstalk between biological and chemical diversity with cytotoxic and cytostatic effects of Aphanothece halophytica in vitro |
| title_sort | crosstalk between biological and chemical diversity with cytotoxic and cytostatic effects of aphanothece halophytica in vitro |
| topic | Aphanothece halophytica biodiversity secondary metabolites cytotoxic cytostatic |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000800801&tlng=en |
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