Clustering of Streptococcus gallolyticus subspecies pasteurianus bacteremia and meningitis in neonates
Background/purpose: Although Streptococcus gallolyticus subspecies pasteurianus (SGSP) is a rare pathogen in children, it can cause invasive infections among neonates and infants. Herein, we report bacteremia/meningitis caused by SGSP in three neonates and review the literature on bacteremia and/or...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Journal of Microbiology, Immunology and Infection |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118220301614 |
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| author | Wan-Chen Chen Ping-Ing Lee Hsiao-Chi Lin Luan-Ying Chang Tai-Fen Lee Jong-Min Chen Po-Ren Hsueh |
| author_facet | Wan-Chen Chen Ping-Ing Lee Hsiao-Chi Lin Luan-Ying Chang Tai-Fen Lee Jong-Min Chen Po-Ren Hsueh |
| author_sort | Wan-Chen Chen |
| collection | DOAJ |
| description | Background/purpose: Although Streptococcus gallolyticus subspecies pasteurianus (SGSP) is a rare pathogen in children, it can cause invasive infections among neonates and infants. Herein, we report bacteremia/meningitis caused by SGSP in three neonates and review the literature on bacteremia and/or meningitis caused by this organism. Methods: Three neonates, referred from an obstetrics clinic within a 2-month period, presented with invasive SGSP infections. The bacterial isolates were analyzed using Bruker Biotyper MALDI-TOF, sequencing of 16S rRNA and sodA genes (encoding manganese dependent superoxide dismutase), and PCR restriction fragment length polymorphism assay of groESL gene. Molecular typing was performed to evaluate the genetic relatedness. Results: The median onset age of infection in the three neonates was 3 days (range 2–5 days). They were delivered through cesarean section in the same operation room under different doctors, and were cared for by different nurses. Patient A presented with bacteremia, patient B with bacteremia and meningitis, and patient C with meningitis. Four isolates were identified as SGSP and were susceptible to penicillin G, cefotaxime, and vancomycin. All patients were treated with ampicillin plus cefotaxime for 14 days, and no complications were observed. The molecular typing results suggested that all isolates belonged to a single clone, which indicated the possibility of an outbreak in the obstetrics clinic. Conclusion: Infection by a rare pathogen such as SGSP in multiple patients belonging to a single healthcare unit indicates that detailed investigation and stringent infection control policy are necessary for preventing further outbreaks of such diseases. |
| first_indexed | 2024-12-24T11:00:46Z |
| format | Article |
| id | doaj.art-2a69d1fddcd5404bbadbab6eba8a7054 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-12-24T11:00:46Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-2a69d1fddcd5404bbadbab6eba8a70542022-12-21T16:58:43ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822021-12-0154610781085Clustering of Streptococcus gallolyticus subspecies pasteurianus bacteremia and meningitis in neonatesWan-Chen Chen0Ping-Ing Lee1Hsiao-Chi Lin2Luan-Ying Chang3Tai-Fen Lee4Jong-Min Chen5Po-Ren Hsueh6Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Pediatrics, Changhua Christian Children's Hospital, Changhua City, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Corresponding author. Department of Laboratory Medicine, National Taiwan University Hospital, Number 7, Chung-Shan South Road, Taipei, 100, Taiwan.Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Corresponding author. Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7 Chung-Shan South Road, Taipei, 100, Taiwan.Background/purpose: Although Streptococcus gallolyticus subspecies pasteurianus (SGSP) is a rare pathogen in children, it can cause invasive infections among neonates and infants. Herein, we report bacteremia/meningitis caused by SGSP in three neonates and review the literature on bacteremia and/or meningitis caused by this organism. Methods: Three neonates, referred from an obstetrics clinic within a 2-month period, presented with invasive SGSP infections. The bacterial isolates were analyzed using Bruker Biotyper MALDI-TOF, sequencing of 16S rRNA and sodA genes (encoding manganese dependent superoxide dismutase), and PCR restriction fragment length polymorphism assay of groESL gene. Molecular typing was performed to evaluate the genetic relatedness. Results: The median onset age of infection in the three neonates was 3 days (range 2–5 days). They were delivered through cesarean section in the same operation room under different doctors, and were cared for by different nurses. Patient A presented with bacteremia, patient B with bacteremia and meningitis, and patient C with meningitis. Four isolates were identified as SGSP and were susceptible to penicillin G, cefotaxime, and vancomycin. All patients were treated with ampicillin plus cefotaxime for 14 days, and no complications were observed. The molecular typing results suggested that all isolates belonged to a single clone, which indicated the possibility of an outbreak in the obstetrics clinic. Conclusion: Infection by a rare pathogen such as SGSP in multiple patients belonging to a single healthcare unit indicates that detailed investigation and stringent infection control policy are necessary for preventing further outbreaks of such diseases.http://www.sciencedirect.com/science/article/pii/S1684118220301614Streptococcus gallolyticus subspecies pasteurianusBacteremiaMeningitisNeonateClustering |
| spellingShingle | Wan-Chen Chen Ping-Ing Lee Hsiao-Chi Lin Luan-Ying Chang Tai-Fen Lee Jong-Min Chen Po-Ren Hsueh Clustering of Streptococcus gallolyticus subspecies pasteurianus bacteremia and meningitis in neonates Journal of Microbiology, Immunology and Infection Streptococcus gallolyticus subspecies pasteurianus Bacteremia Meningitis Neonate Clustering |
| title | Clustering of Streptococcus gallolyticus subspecies pasteurianus bacteremia and meningitis in neonates |
| title_full | Clustering of Streptococcus gallolyticus subspecies pasteurianus bacteremia and meningitis in neonates |
| title_fullStr | Clustering of Streptococcus gallolyticus subspecies pasteurianus bacteremia and meningitis in neonates |
| title_full_unstemmed | Clustering of Streptococcus gallolyticus subspecies pasteurianus bacteremia and meningitis in neonates |
| title_short | Clustering of Streptococcus gallolyticus subspecies pasteurianus bacteremia and meningitis in neonates |
| title_sort | clustering of streptococcus gallolyticus subspecies pasteurianus bacteremia and meningitis in neonates |
| topic | Streptococcus gallolyticus subspecies pasteurianus Bacteremia Meningitis Neonate Clustering |
| url | http://www.sciencedirect.com/science/article/pii/S1684118220301614 |
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