Optical and pharmacological manipulation of hypoglossal motor nucleus identifies differential effects of taltirelin on sleeping tonic motor activity and responsiveness

Optical and pharmacological manipulation of hypoglossal motor nucleus identifies differential effects of taltirelin on sleeping tonic motor activity and responsiveness

Abstract Pharyngeal muscle activity and responsiveness are key pathophysiological traits in human obstructive sleep apnea (OSA) and strong contributors to improvements with pharmacotherapy. The thyrotropin-releasing hormone (TRH) analog taltirelin is of high pre-clinical interest given its neuronal-...

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Bibliographic Details
Main Authors:	Jasmin Aggarwal, Raina Ladha, Wen-Ying Liu, Hattie Liu, Richard L. Horner
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-07-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-023-39562-z

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