Lung remodeling in a mouse model of asthma involves a balance between TGF-β1 and BMP-7.

Lung remodeling in a mouse model of asthma involves a balance between TGF-β1 and BMP-7.

A key event in chronic allergic asthma is the TGF-β-induced activation of fibroblasts into α-SMA-positive myofibroblasts which synthesize type-I collagen. In the present study we investigated the effect of the anti-fibrotic molecule BMP-7 in asthma. Balb/c mice were immunized i.p. with ovalbumin in...

Full description

Bibliographic Details
Main Authors: Camila Leindecker Stumm, Erik Halcsik, Richardt Gama Landgraf, Niels Olsen Saraiva Camara, Mari Cleide Sogayar, Sonia Jancar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4004563?pdf=render

Similar Items

Similar Items