| Summary: | Silver nanoparticles (AgNPs) made by green synthesis offer a variety of biochemical properties and are an excellent alternative to traditional medications due to their low cost. In the current study, we synthesised AgNPs from the leaf extract of the medicinal plant <i>Uvaria narum</i>, commonly called narumpanal. The nanoparticles were characterised by ultraviolet-visible (UV-Vis) spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). SEM analysis showed AgNPs are highly crystalline and spherical with an average diameter of 7.13 nm. The outstanding catalytic activity of AgNPs was demonstrated by employing the reduction of 4-nitrophenol to 4-aminophenol. The AgNPs showed antiangiogenic activity in the chick chorioallantoic membrane (CAM) assay. AgNPs demonstrated anticancer activity against Dalton’s lymphoma ascites cells (DLA cells) in trypan blue assay and cytotoxicity against three fish cell lines: <i>Oreochromis niloticus</i> liver (onlL; National Repository of Fish Cell Lines, India (NRFC) Accession number—NRFC052) cells, <i>Cyprinus carpio</i> koi fin (CCKF; NRFC Accession number—NRFC007) cells and <i>Cyprinus carpio</i> gill (CyCKG; NRFC Accession number—NRFC064). Furthermore, the AgNPs demonstrated their ability to inhibit pathogenic microorganisms, <i>Staphylococcus aureus</i>, and <i>Escherichia coli.</i> The results from the study displayed green synthesised AgNPs exhibit antiangiogenic activity, cytotoxicity, antimicrobial and catalytic properties, which are crucial characteristics of a molecule with excellent clinical applications.
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