Measurement of bradykinesia and chorea in Huntington's Disease using ambulatory monitoring
Objectives: The feasibility of measuring bradykinesia and chorea in Huntington's Disease using a wearable sensor system (Parkinson’s Kinetigraph: PKG) developed for measuring bradykinesia and dyskinesia in Parkinson’s Disease was assessed. Methods: Unified Huntington’s Disease Rating Scales (UH...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Clinical Parkinsonism & Related Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590112522000500 |
| _version_ | 1797827760526196736 |
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| author | Katya Kotschet Sarah Osborn Malcolm Horne |
| author_facet | Katya Kotschet Sarah Osborn Malcolm Horne |
| author_sort | Katya Kotschet |
| collection | DOAJ |
| description | Objectives: The feasibility of measuring bradykinesia and chorea in Huntington's Disease using a wearable sensor system (Parkinson’s Kinetigraph: PKG) developed for measuring bradykinesia and dyskinesia in Parkinson’s Disease was assessed. Methods: Unified Huntington’s Disease Rating Scales (UHDRS) and a PKG were obtained for 25 people with Huntington's Disease. Bradykinesia and Chorea Score were derived from relevant sub-scores of the UHDRS and compared with the PKG’s bradykinesia and dyskinesia scores. The PKG’s daytime sleepiness score was also used. Results: There was good correlation between Chorea Scores and the PKG’s dyskinesia score (Pearson’s ρ = 0.66). Correlation between the Bradykinesia Scores and the PKG’s bradykinesia score was also good (Pearson’s ρ = 0.51) in cases whose PKG scores were in the normal or bradykinetic range. The PKG’s bradykinesia score of 23, which is in the higher range of control subjects, separated participants into those with Independence Score ≥ 80 or < 80 and a Functional Assessment (FAS) score ≥ 18 or < 18. The PKG’s daytime sleep score was high in 44 % of participants, whose average time asleep was 21 % compared to 1.6 % in participants with a normal sleep index. Participants with high sleep scores were significantly more likely to have low Independence and TFC scores. Conclusions: Measures of bradykinesia and dyskinesia from clinical scales have acceptable correlations with those from the PKG. Continuous monitoring provides information about daytime sleep, which was associated with lower functional status. Further studies and larger sample sizes are required to confirm these findings and the utility of this measure in Huntington's Disease. |
| first_indexed | 2024-04-09T12:53:32Z |
| format | Article |
| id | doaj.art-2a713896b93b4b3487190b47655c2fcf |
| institution | Directory Open Access Journal |
| issn | 2590-1125 |
| language | English |
| last_indexed | 2024-04-09T12:53:32Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Parkinsonism & Related Disorders |
| spelling | doaj.art-2a713896b93b4b3487190b47655c2fcf2023-05-14T04:29:29ZengElsevierClinical Parkinsonism & Related Disorders2590-11252023-01-018100179Measurement of bradykinesia and chorea in Huntington's Disease using ambulatory monitoringKatya Kotschet0Sarah Osborn1Malcolm Horne2Department of Clinical Neurosciences, St Vincent’s Hospital, Fitzroy, Vic, AustraliaDepartment of Clinical Neurosciences, St Vincent’s Hospital, Fitzroy, Vic, Australia; 3065Parkinsons Laboratory, Florey Institute of Neurosciences and Mental Health, Parkville, Vic 3010, AustraliaDepartment of Clinical Neurosciences, St Vincent’s Hospital, Fitzroy, Vic, Australia; 3065Parkinsons Laboratory, Florey Institute of Neurosciences and Mental Health, Parkville, Vic 3010, Australia; Corresponding author at: Department of Clinical Neurosciences, St Vincent’s Hospital, Fitzroy, Vic, Australia (M. Home).Objectives: The feasibility of measuring bradykinesia and chorea in Huntington's Disease using a wearable sensor system (Parkinson’s Kinetigraph: PKG) developed for measuring bradykinesia and dyskinesia in Parkinson’s Disease was assessed. Methods: Unified Huntington’s Disease Rating Scales (UHDRS) and a PKG were obtained for 25 people with Huntington's Disease. Bradykinesia and Chorea Score were derived from relevant sub-scores of the UHDRS and compared with the PKG’s bradykinesia and dyskinesia scores. The PKG’s daytime sleepiness score was also used. Results: There was good correlation between Chorea Scores and the PKG’s dyskinesia score (Pearson’s ρ = 0.66). Correlation between the Bradykinesia Scores and the PKG’s bradykinesia score was also good (Pearson’s ρ = 0.51) in cases whose PKG scores were in the normal or bradykinetic range. The PKG’s bradykinesia score of 23, which is in the higher range of control subjects, separated participants into those with Independence Score ≥ 80 or < 80 and a Functional Assessment (FAS) score ≥ 18 or < 18. The PKG’s daytime sleep score was high in 44 % of participants, whose average time asleep was 21 % compared to 1.6 % in participants with a normal sleep index. Participants with high sleep scores were significantly more likely to have low Independence and TFC scores. Conclusions: Measures of bradykinesia and dyskinesia from clinical scales have acceptable correlations with those from the PKG. Continuous monitoring provides information about daytime sleep, which was associated with lower functional status. Further studies and larger sample sizes are required to confirm these findings and the utility of this measure in Huntington's Disease.http://www.sciencedirect.com/science/article/pii/S2590112522000500Huntington’s DiseaseWearable sensorsBiosensorsMovement disordersDaytime sleep |
| spellingShingle | Katya Kotschet Sarah Osborn Malcolm Horne Measurement of bradykinesia and chorea in Huntington's Disease using ambulatory monitoring Clinical Parkinsonism & Related Disorders Huntington’s Disease Wearable sensors Biosensors Movement disorders Daytime sleep |
| title | Measurement of bradykinesia and chorea in Huntington's Disease using ambulatory monitoring |
| title_full | Measurement of bradykinesia and chorea in Huntington's Disease using ambulatory monitoring |
| title_fullStr | Measurement of bradykinesia and chorea in Huntington's Disease using ambulatory monitoring |
| title_full_unstemmed | Measurement of bradykinesia and chorea in Huntington's Disease using ambulatory monitoring |
| title_short | Measurement of bradykinesia and chorea in Huntington's Disease using ambulatory monitoring |
| title_sort | measurement of bradykinesia and chorea in huntington s disease using ambulatory monitoring |
| topic | Huntington’s Disease Wearable sensors Biosensors Movement disorders Daytime sleep |
| url | http://www.sciencedirect.com/science/article/pii/S2590112522000500 |
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