Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies
The worldwide incidence of differentiated thyroid cancer (DTC) has increased in recent decades, likely due to frequent use of cervical ultrasonography (US) and US-guided fine needle aspiration biopsy (FNA)., US is performed during follow-up after thyroidectomy, and US-guided FNA with cytology is use...
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2020-01-01
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| Series: | Acta Clinica Croatica |
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| Online Access: | https://hrcak.srce.hr/file/360656 |
| _version_ | 1818947991525916672 |
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| author | Ivan Blažeković Matija Romić Marija Bosak Butković Ines Šiško Markoš Vedrana Gladić Nenadić Valentina Vidranski Petra Petranović Ovčariček Dražena Krilić Tea Varjačić Josip Staničić Roko Granić Marija Punda Ivan Mihaljević Tomislav Jukić Maja Franceschi |
| author_facet | Ivan Blažeković Matija Romić Marija Bosak Butković Ines Šiško Markoš Vedrana Gladić Nenadić Valentina Vidranski Petra Petranović Ovčariček Dražena Krilić Tea Varjačić Josip Staničić Roko Granić Marija Punda Ivan Mihaljević Tomislav Jukić Maja Franceschi |
| author_sort | Ivan Blažeković |
| collection | DOAJ |
| description | The worldwide incidence of differentiated thyroid cancer (DTC) has increased in recent decades, likely due to frequent use of cervical ultrasonography (US) and US-guided fine needle aspiration biopsy (FNA)., US is performed during follow-up after thyroidectomy, and US-guided FNA with cytology is used if suspicious cervical lymph nodes (LN ) or thyroid bed masses are detected. Knowing that serum anti-Tg antibodies (sTgAb) affect the use of serum Tg (sTg) as a tumor marker, the aim of our study was to assess the usefulness of Tg determination in needle aspirates (FNA-Tg) in presence of sTgAb. This retrospective study included 149 patients with DTC and 159 aspirations of suspicious LN and thyroid bed masses. As expected, there was a negative correlation between sTg and sTgAb levels (p<0.05), while FNA-Tg levels had a positive correlation with FNATgAb levels (p<0.05). Furthermore, we found a positive correlation between sTg and FNA-Tg levels (p<0.05), but not between sTgAb and FNA-TgAb or sTgAb and FNA-Tg. In conclusion, these results show that FNA-Tg values were not affected by sTgAb and that FNA-Tg measurement were highly effective in detecting cervical DTC metastases. However, combined use with cytology is suggested for neck evaluation because cytology could reveal metastases from other tumor sites. |
| first_indexed | 2024-12-20T08:39:42Z |
| format | Article |
| id | doaj.art-2a7168be8ece41e7b824ea576a07bcb2 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-12-20T08:39:42Z |
| publishDate | 2020-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-2a7168be8ece41e7b824ea576a07bcb22022-12-21T19:46:26ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512020-01-0159.Supplement 1917Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg AntibodiesIvan Blažeković0Matija Romić1Marija Bosak Butković2Ines Šiško Markoš3Vedrana Gladić Nenadić4Valentina Vidranski5Petra Petranović Ovčariček6Dražena Krilić7Tea Varjačić8Josip Staničić9Roko Granić10Marija Punda11Ivan Mihaljević12Tomislav Jukić13Maja Franceschi14Department of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaFaculty of Medicine, University of Osijek, Osijek, Croatia; Department for Nuclear Medicine and Radiation Protection, Osijek University Hospital Center, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, CroatiaDepartment of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Faculty of Medicine, University of Osijek, Osijek, CroatiaThe worldwide incidence of differentiated thyroid cancer (DTC) has increased in recent decades, likely due to frequent use of cervical ultrasonography (US) and US-guided fine needle aspiration biopsy (FNA)., US is performed during follow-up after thyroidectomy, and US-guided FNA with cytology is used if suspicious cervical lymph nodes (LN ) or thyroid bed masses are detected. Knowing that serum anti-Tg antibodies (sTgAb) affect the use of serum Tg (sTg) as a tumor marker, the aim of our study was to assess the usefulness of Tg determination in needle aspirates (FNA-Tg) in presence of sTgAb. This retrospective study included 149 patients with DTC and 159 aspirations of suspicious LN and thyroid bed masses. As expected, there was a negative correlation between sTg and sTgAb levels (p<0.05), while FNA-Tg levels had a positive correlation with FNATgAb levels (p<0.05). Furthermore, we found a positive correlation between sTg and FNA-Tg levels (p<0.05), but not between sTgAb and FNA-TgAb or sTgAb and FNA-Tg. In conclusion, these results show that FNA-Tg values were not affected by sTgAb and that FNA-Tg measurement were highly effective in detecting cervical DTC metastases. However, combined use with cytology is suggested for neck evaluation because cytology could reveal metastases from other tumor sites.https://hrcak.srce.hr/file/360656neck ultrasonography, differentiated thyroid carcinoma, fine needle aspiration (FNA), serum thyroglobulin (sTg), serum anti-Tg antibodies (sTg-Ab), thyroglobulin (Tg) in FNA (FNA-Tg), FNA anti-Tg antibodies (FNA-TgAb) |
| spellingShingle | Ivan Blažeković Matija Romić Marija Bosak Butković Ines Šiško Markoš Vedrana Gladić Nenadić Valentina Vidranski Petra Petranović Ovčariček Dražena Krilić Tea Varjačić Josip Staničić Roko Granić Marija Punda Ivan Mihaljević Tomislav Jukić Maja Franceschi Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies Acta Clinica Croatica neck ultrasonography, differentiated thyroid carcinoma, fine needle aspiration (FNA), serum thyroglobulin (sTg), serum anti-Tg antibodies (sTg-Ab), thyroglobulin (Tg) in FNA (FNA-Tg), FNA anti-Tg antibodies (FNA-TgAb) |
| title | Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies |
| title_full | Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies |
| title_fullStr | Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies |
| title_full_unstemmed | Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies |
| title_short | Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies |
| title_sort | thyroglobulin measurement in needle aspiration for detection of recurrences and neck metastases in patients with differentiated thyroid carcinoma significance of anti tg antibodies |
| topic | neck ultrasonography, differentiated thyroid carcinoma, fine needle aspiration (FNA), serum thyroglobulin (sTg), serum anti-Tg antibodies (sTg-Ab), thyroglobulin (Tg) in FNA (FNA-Tg), FNA anti-Tg antibodies (FNA-TgAb) |
| url | https://hrcak.srce.hr/file/360656 |
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